Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Microtubule-associated protein tau (MAPT) | Clinical trial | Target Info | ||
UniProt ID | TAU_HUMAN | ||||
Gene Name | MAPT | ||||
Gene ID | 4137 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Fyn tyrosine protein kinase (FYN) | Target Info | PPI Info | [2] | ||
Interacting Clinical trial Target(s) | Glycogen synthase kinase-3 beta (GSK-3B) | Target Info | PPI Info | [3] | |
Rotamase Pin1 (PIN1) | Target Info | PPI Info | [4] | ||
Synuclein alpha (SNCA) | Target Info | PPI Info | [5] | ||
Interacting Literature-reported Target(s) | Lipopolysaccharide-associated protein 1 (HSPA8) | Target Info | PPI Info | [6] |
References | Top | ||||
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REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 2 | Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J Neurosci. 2002 Feb 1;22(3):698-707. | ||||
REF 3 | NUB1 modulation of GSK3 reduces tau aggregation. Hum Mol Genet. 2012 Dec 15;21(24):5254-67. | ||||
REF 4 | Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions. J Biol Chem. 2006 Feb 17;281(7):4117-25. | ||||
REF 5 | Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation. Exp Cell Res. 2005 Aug 1;308(1):78-84. | ||||
REF 6 | CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem. 2004 Feb 6;279(6):4869-76. |
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