Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T17980 Target Info
Target Name Fyn tyrosine protein kinase (FYN)
Synonyms Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Fyn p59-Fyn; Fyn Protooncogene Syn
Target Type Successful Target
Gene Name FYN
Biochemical Class Kinase
UniProt ID
FYN_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Affinity Capture-Western [8]
9 Affinity Capture-Western [9]
10 Affinity Capture-Western [10]
11 Biochemical Activity [4]
12 Biochemical Activity [11]
13 Reconstituted Complex [8]
14 Reconstituted Complex [12]
15 Reconstituted Complex [13]
16 Reconstituted Complex [14]
17 Reconstituted Complex [4]
18 Reconstituted Complex [5]
19 Reconstituted Complex [15]
20 Yeast two hybrid [8]
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Glutamate receptor ionotropic NMDA 2A (NMDAR2A) Successful Target Interacting Protein Info
UniProt ID
NMDE1_HUMAN 
Synonyms NR2A; N-methyl D-aspartate receptor subtype 2A; NMDA receptor NR2A; HNR2A; Glutamate receptor ionotropic, NMDA 2A; Glutamate [NMDA] receptor subunit epsilon-1; GluN2A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [17]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [18]
2 Affinity Capture-Western [19]
3 Affinity Capture-Western [20]
Kinases [+] 4 Kinases +
Interacting Target Name Focal adhesion kinase 2 (PTK2B) Literature-reported Target Interacting Protein Info
UniProt ID
FAK2_HUMAN 
Synonyms Related adhesion focal tyrosine kinase; RAFTK; PYK2; Protein-tyrosine kinase 2-beta; Proline-rich tyrosine kinase 2; FAK2; FADK 2; Cell adhesion kinase beta; Calcium-regulated non-receptor proline-rich tyrosine kinase; Calcium-dependent tyrosine kinase; CAK-beta; CAKB; CADTK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Affinity Capture-Western [22]
3 Biochemical Activity [21]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Protein-peptide [24]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Co-crystal Structure [26]
Interacting Target Name Ribosomal protein S6 kinase alpha-3 (RSK3) Patented-recorded Target Interacting Protein Info
UniProt ID
KS6A3_HUMAN 
Synonyms S6K-alpha-3; RSK-2; RSK2; Ribosomal S6 kinase 2; pp90RSK2; p90RSK3; p90-RSK 3; MAPKAPK-1b; MAPKAPK1B; MAPKAP kinase 1b; MAPK-activated protein kinase 1b; MAP kinase-activated protein kinase 1b; ISPK-1; ISPK1; Insulin-stimulated protein kinase 1; 90 kDa ribosomal protein S6 kinase 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [18]
2 Biochemical Activity [27]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Microtubule-associated protein tau (MAPT) Clinical trial Target Interacting Protein Info
UniProt ID
TAU_HUMAN 
Synonyms tau; TAU; Paired helical filament-tau; Paired helical filamenttau; Neurofibrillary tangle protein; MTBT1; Microtubule-associated protein tau; MAPTL
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Biochemical Activity [29]
3 Reconstituted Complex [28]
4 Reconstituted Complex [29]
Other proteins [+] 11 Other proteins +
Interacting Protein Name FYN-binding protein 1 (FYB1) Interacting Protein Interacting Protein Info
UniProt ID
FYB1_HUMAN 
Synonyms ADAP; PRO0823; SLAP.130; SLAP130
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Affinity Capture-Western [31]
3 Affinity Capture-Western [22]
4 Affinity Capture-Western [32]
5 Reconstituted Complex [30]
Interacting Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) Literature-reported Target Interacting Protein Info
UniProt ID
KHDR1_HUMAN 
Synonyms Src-associated in mitosis 68 kDa protein; Srcassociated in mitosis 68 kDa protein; Sam68; p68; p21 Ras GTPase-activating protein-associated p62; p21 Ras GTPaseactivating proteinassociated p62; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; GAPassociated tyrosine phosphoprotein p62
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Affinity Capture-Western [33]
3 Biochemical Activity [10]
4 Reconstituted Complex [34]
Interacting Protein Name Src kinase-associated phosphoprotein 1 (SKAP1) Interacting Protein Interacting Protein Info
UniProt ID
SKAP1_HUMAN 
Synonyms HEL.S.81p; SCAP1; SKAP55
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Affinity Capture-Western [31]
3 Affinity Capture-Western [22]
4 Reconstituted Complex [36]
Interacting Target Name Wiskott-Aldrich syndrome protein (WAS) Clinical trial Target Interacting Protein Info
UniProt ID
WASP_HUMAN 
Synonyms WASp; IMD2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Biochemical Activity [38]
3 Reconstituted Complex [37]
Interacting Target Name Apoptosis antigen ligand (CD178) Literature-reported Target Interacting Protein Info
UniProt ID
TNFL6_HUMAN 
Synonyms Tumor necrosis factor ligand superfamily member 6; TNFSF6; FasL; Fas ligand; FAS antigen ligand; CD95-L; CD95L; CD95 ligand; CD178 antigen; CD178; APTL; APT1LG1; Apoptosis antigen ligand
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [39]
2 Protein-peptide [40]
3 Reconstituted Complex [41]
Interacting Protein Name Embryonal Fyn-associated substrate (EFS) Interacting Protein Interacting Protein Info
UniProt ID
EFS_HUMAN 
Synonyms CAS3; CASS3; EFS1; EFS2; HEFS; SIN
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [42]
2 Reconstituted Complex [42]
3 Yeast two hybrid [43]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [44]
2 Co-localization [39]
Interacting Protein Name Catenin delta-1 (CTNND1) Interacting Protein Interacting Protein Info
UniProt ID
CTND1_HUMAN 
Synonyms CAS; CTNND; P120CAS; P120CTN; p120; p120(CAS); p120(CTN)
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Biochemical Activity [45]
Interacting Protein Name Src kinase-associated phosphoprotein 2 (SKAP2) Interacting Protein Interacting Protein Info
UniProt ID
SKAP2_HUMAN 
Synonyms PRAP; RA70; SAPS; SCAP2; SKAP.HOM; SKAP55R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Biochemical Activity [47]
Interacting Protein Name TOM1-like protein 1 (TOM1L1) Interacting Protein Interacting Protein Info
UniProt ID
TM1L1_HUMAN 
Synonyms OK/KNS.CL.3; SRCASM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Reconstituted Complex [49]
Interacting Protein Name Proto-oncogene vav (VAV1) Interacting Protein Interacting Protein Info
UniProt ID
VAV_HUMAN 
Synonyms VAV
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Yeast two hybrid [51]
References  Top
REF 1 c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. J Immunol. 2002 Oct 1;169(7):3793-800.
REF 2 Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997 Oct 3;278(5335):124-8.
REF 3 Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45. Blood Cells Mol Dis. 2006 Mar-Apr;36(2):308-14.
REF 4 Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells. J Biol Chem. 1996 Oct 25;271(43):27130-7.
REF 5 The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J Biol Chem. 1995 Aug 11;270(32):19141-50.
REF 6 Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase. J Biol Chem. 1997 Jan 10;272(2):739-45.
REF 7 A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes. Exp Cell Res. 2003 Sep 10;289(1):184-94.
REF 8 Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. J Biol Chem. 1998 Apr 10;273(15):8867-74.
REF 9 Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase. J Biol Chem. 2004 Aug 20;279(34):36132-41.
REF 10 Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem. 2004 Aug 27;279(35):36259-67.
REF 11 Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. FEBS Lett. 2004 Nov 19;577(3):555-62.
REF 12 The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6439-44.
REF 13 Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem. 1996 Apr 5;271(14):8435-42.
REF 14 Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J Biol Chem. 1996 Jun 14;271(24):14554-9.
REF 15 Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J Biol Chem. 1995 Jun 16;270(24):14347-51.
REF 16 Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia. Brain Res. 2002 Nov 15;955(1-2):123-32.
REF 17 The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains. J Cereb Blood Flow Metab. 1999 Aug;19(8):880-8.
REF 18 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 19 Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. EMBO Rep. 2006 Oct;7(10):1023-9.
REF 20 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 21 Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J Exp Med. 1997 Apr 7;185(7):1253-9.
REF 22 Molecular alterations of the Fyn-complex occur as late events of human T cell activation. Eur J Immunol. 1999 Apr;29(4):1175-87.
REF 23 An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin. J Cell Biochem. 2009 Nov 1;108(4):851-9.
REF 24 Identification of novel human WW domain-containing proteins by cloning of ligand targets. J Biol Chem. 1997 Jun 6;272(23):14611-6.
REF 25 Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin. J Neurochem. 2003 Jan;84(2):253-65.
REF 26 The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. J Biol Chem. 2001 May 18;276(20):17199-205.
REF 27 Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529. J Biol Chem. 2008 Feb 22;283(8):4652-7.
REF 28 Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J Neurosci. 2002 Feb 1;22(3):698-707.
REF 29 Disease-related modifications in tau affect the interaction between Fyn and Tau. J Biol Chem. 2005 Oct 21;280(42):35119-25.
REF 30 T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T). J Exp Med. 1993 Dec 1;178(6):2107-13.
REF 31 Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. J Biol Chem. 1998 Oct 2;273(40):25789-95.
REF 32 Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7493-8.
REF 33 Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. PLoS One. 2012;7(6):e38540.
REF 34 UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. Oncogene. 2002 Mar 27;21(13):2037-50.
REF 35 SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. J Biol Chem. 2002 Oct 25;277(43):40420-7.
REF 36 Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. J Biol Chem. 1997 Jun 27;272(26):16077-80.
REF 37 Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases. Curr Biol. 1996 Aug 1;6(8):981-8.
REF 38 Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell. 2002 Nov;3(5):645-58.
REF 39 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 40 Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. BMC Immunol. 2009 Oct 6;10:53.
REF 41 Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. FEBS Lett. 2001 Dec 7;509(2):255-62.
REF 42 Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin. J Immunol. 2002 Dec 15;169(12):6900-9.
REF 43 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 44 p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol. 2003 Apr;23(7):2287-97.
REF 45 Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho. J Cell Biol. 2003 Jul 7;162(1):99-111.
REF 46 RA70 is a src kinase-associated protein expressed ubiquitously. Biochem Biophys Res Commun. 1998 Nov 27;252(3):738-42.
REF 47 Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. J Biol Chem. 2003 Oct 24;278(43):42225-33.
REF 48 TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation. Mediators Inflamm. 2009;2009:416298.
REF 49 'Srcasm: a novel Src activating and signaling molecule. J Biol Chem. 2002 Jan 25;277(4):2812-22.
REF 50 Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells. J Biol Chem. 1998 Nov 27;273(48):31932-8.
REF 51 Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. J Biol Chem. 2001 Jun 15;276(24):20849-57.

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