Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Wiskott-Aldrich syndrome protein (WAS) | Clinical trial | Target Info | ||
UniProt ID | WASP_HUMAN | ||||
Gene Name | WAS | ||||
Gene ID | 7454 |
Interacting TTD Target Information | Top | ||||
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Interacting Successful Target(s) | LCK tyrosine protein kinase (LCK) | Target Info | PPI Info | [1] | |
Proto-oncogene c-Src (SRC) | Target Info | PPI Info | [2] | ||
Tyrosine-protein kinase BTK (ATK) | Target Info | PPI Info | [3] | ||
Fyn tyrosine protein kinase (FYN) | Target Info | PPI Info | [2] | ||
Interacting Clinical trial Target(s) | NCK adaptor protein 1 (NCK1) | Target Info | PPI Info | [4] | |
Interacting Literature-reported Target(s) | Tyrosine-protein kinase Fgr (FGR) | Target Info | PPI Info | [2] |
References | Top | ||||
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REF 1 | A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions. Gene. 2005 Oct 10;359:18-25. | ||||
REF 2 | Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases. Curr Biol. 1996 Aug 1;6(8):981-8. | ||||
REF 3 | The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. Eur J Immunol. 1999 Jul;29(7):2269-79. | ||||
REF 4 | Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol. 2000 Apr 3;149(1):181-94. |
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