Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T25005 | Target Info | |||
Target Name | Tyrosine-protein kinase BTK (ATK) | ||||
Synonyms | Bruton's tyrosine kinase; Bruton tyrosine kinase; BPK; B-cell progenitor kinase; B cell progenitor kinase; Agammaglobulinemia tyrosine kinase; Agammaglobulinaemia tyrosine kinase; AGMX1 | ||||
Target Type | Successful Target | ||||
Gene Name | BTK | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
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Acyltransferases | [+] 1 Acyltransferases | + | |||
Interacting Target Name | Signal transduction protein CBL (CBL) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Co-crystal Structure | [2] | |||
3 | Protein-peptide | [3] | |||
4 | Reconstituted Complex | [4] | |||
Adapter proteins | [+] 1 Adapter proteins | + | |||
Interacting Protein Name | Growth factor receptor-bound protein 2 (GRB2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [5] | |||
2 | Yeast two hybrid | [6] | |||
Transcription regulators | [+] 1 Transcription regulators | + | |||
Interacting Protein Name | General transcription factor II-I (GTF2I) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BAP135; BTKAP1; DIWS; GTFII.I; IB291; SPIN; TFII.I; WBS; WBSCR6 | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [7] | |||
2 | Biochemical Activity | [8] | |||
3 | Reconstituted Complex | [7] | |||
4 | Reconstituted Complex | [9] | |||
5 | Reconstituted Complex | [10] | |||
Other proteins | [+] 3 Other proteins | + | |||
Interacting Target Name | Wiskott-Aldrich syndrome protein (WAS) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | WASp; IMD2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Reconstituted Complex | [11] | |||
Interacting Protein Name | B-cell linker protein (BLNK) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AGM4; BASH; BLNK.S; LY57; SLP.65; SLP65; bca | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [12] | |||
2 | Affinity Capture-Western | [13] | |||
Interacting Protein Name | Inhibitor of Bruton tyrosine kinase (IBTK) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BTBD26; BTKI | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [14] | |||
2 | Reconstituted Complex | [15] |
References | Top | ||||
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REF 1 | The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. Eur J Immunol. 1999 Jul;29(7):2269-79. | ||||
REF 2 | Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl. J Biomol NMR. 2000 Apr;16(4):303-12. | ||||
REF 3 | SH3 domain of Bruton's tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cbl. Proteins. 1997 Dec;29(4):545-52. | ||||
REF 4 | The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J Exp Med. 1995 Aug 1;182(2):611-5. | ||||
REF 5 | Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9. | ||||
REF 6 | A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5. | ||||
REF 7 | Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I. J Biol Chem. 2004 Feb 20;279(8):7147-58. | ||||
REF 8 | Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I. J Biol Chem. 2001 Jul 27;276(30):27806-15. | ||||
REF 9 | BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):604-9. | ||||
REF 10 | Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes. Int Immunol. 2004 May;16(5):747-57. | ||||
REF 11 | Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J Immunol. 1996 Nov 1;157(9):3791-5. | ||||
REF 12 | Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood. 1999 Oct 1;94(7):2357-64. | ||||
REF 13 | Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med. 2002 Jul 1;196(1):51-63. | ||||
REF 14 | Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. Nucleic Acids Res. 2008 Aug;36(13):4402-16. | ||||
REF 15 | Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Nat Immunol. 2001 Oct;2(10):939-46. |
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