| References |
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| REF 1 |
c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment. Cell Signal. 2010 Mar;22(3):377-85.
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| REF 2 |
A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes. Exp Cell Res. 2003 Sep 10;289(1):184-94.
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| REF 3 |
Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl. FEBS J. 2006 Dec;273(23):5442-56.
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| REF 4 |
Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J Biol Chem. 1995 Jun 16;270(24):14347-51.
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| REF 5 |
SH3P2 in complex with Cbl and Src. FEBS Lett. 2004 May 7;565(1-3):33-8.
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| REF 6 |
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7036-41.
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| REF 7 |
PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases. FEBS Lett. 2006 Dec 22;580(30):6769-76.
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| REF 8 |
The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6439-44.
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| REF 9 |
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell. 1999 Dec;4(6):1041-9.
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| REF 10 |
TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia. J Biol Chem. 2012 May 11;287(20):16132-45.
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| REF 11 |
Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. J Biochem. 2012 Nov;152(5):487-95.
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| REF 12 |
Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene. 2004 Mar 4;23(9):1645-55.
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| REF 13 |
Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src. Oncogene. 2006 Jul 27;25(32):4495-500.
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| REF 14 |
c-Src/histone deacetylase 3 interaction is crucial for hepatocyte growth factor dependent decrease of CXCR4 expression in highly invasive breast tu... Mol Cancer Res. 2007 Aug;5(8):833-45.
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| REF 15 |
Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples. Cancer Res. 2002 May 1;62(9):2699-707.
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| REF 16 |
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms. Biol Reprod. 2013 Mar 28;88(3):77.
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| REF 17 |
Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression. FEBS Lett. 2000 Dec 15;486(3):275-80.
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| REF 18 |
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
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| REF 19 |
Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J Cell Biol. 1999 Mar 8;144(5):1019-31.
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| REF 20 |
Phospho-tyrosine dependent protein-protein interaction network. Mol Syst Biol. 2015 Mar 26;11(3):794.
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| REF 21 |
Degradation of HER2 by Cbl-based chimeric ubiquitin ligases. Cancer Res. 2007 Sep 15;67(18):8716-24.
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| REF 22 |
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell. 2010 Nov 16;18(5):423-35.
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| REF 23 |
C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells. BMC Cancer. 2018 May 2;18(1):507.
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| REF 24 |
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner. J Biol Chem. 2002 Oct 11;277(41):38486-93.
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| REF 25 |
Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene. 1998 May;16(20):2657-70.
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| REF 26 |
Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene. 2000 Jan 13;19(2):177-87.
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| REF 27 |
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem. 2006 Dec 8;281(49):37527-35.
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| REF 28 |
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. J Biol Chem. 2009 Mar 20;284(12):8185-94.
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| REF 29 |
Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. J Biol Chem. 2003 Nov 28;278(48):47713-23.
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| REF 30 |
The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation. Biochem J. 2011 Apr 15;435(2):355-64.
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| REF 31 |
Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src). J Biol Chem. 2000 Apr 28;275(17):12619-25.
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| REF 32 |
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature. 1996 Oct 10;383(6600):547-50.
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| REF 33 |
Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1. J Biol Chem. 1999 Oct 22;274(43):30657-63.
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| REF 34 |
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
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| REF 35 |
In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
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| REF 36 |
c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. J Biol Chem. 2003 Mar 14;278(11):9944-52.
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| REF 37 |
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex. J Biochem. 2005 Feb;137(2):189-97.
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| REF 38 |
Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation. Mol Pharmacol. 2004 Dec;66(6):1465-77.
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| REF 39 |
An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin. J Cell Biochem. 2009 Nov 1;108(4):851-9.
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| REF 40 |
Identification of novel human WW domain-containing proteins by cloning of ligand targets. J Biol Chem. 1997 Jun 6;272(23):14611-6.
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| REF 41 |
Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO J. 2000 Oct 16;19(20):5406-17.
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| REF 42 |
Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment. J Mol Endocrinol. 2004 Feb;32(1):307-23.
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| REF 43 |
Epidermal growth factor directs sex-specific steroid signaling through Src activation. J Biol Chem. 2007 Apr 6;282(14):10697-706.
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| REF 44 |
Binding of the ER and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-related transcription. J Cell Sci. 2012 Apr 15;125(Pt 8):2004-16.
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| REF 45 |
The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage. Mol Cell Biol. 2001 Oct;21(20):7105-14.
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| REF 46 |
Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells. Nat Commun. 2013;4:2443.
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| REF 47 |
The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. EMBO J. 2006 Sep 20;25(18):4223-33.
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| REF 48 |
PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1. EMBO J. 2007 Aug 8;26(15):3534-44.
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| REF 49 |
The nuclear receptor coactivator PGC-1alpha exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1. J Mol Biol. 2005 Apr 15;347(5):921-34.
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| REF 50 |
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010 Jun;24(6):1151-64.
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| REF 51 |
Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor. Nucleic Acids Res. 2006 Jan 24;34(2):543-54.
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| REF 52 |
Dynamic and ligand-selective interactions of vitamin D receptor with retinoid X receptor and cofactors in living cells. Mol Pharmacol. 2011 Dec;80(6):1147-55.
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| REF 53 |
Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol. 2003 Nov;17(11):2320-8.
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| REF 54 |
Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol. 1996 Apr;16(4):1595-603.
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| REF 55 |
A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells. PLoS One. 2011 May 5;6(5):e19605.
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| REF 56 |
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 2005 Apr 28;24(19):3110-20.
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| REF 57 |
Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci. 2005 Jan 15;118(Pt 2):301-11.
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| REF 58 |
Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1. Biochem J. 2012 Mar 15;442(3):611-20.
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| REF 59 |
Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. PLoS One. 2012;7(6):e38540.
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| REF 60 |
UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. Oncogene. 2002 Mar 27;21(13):2037-50.
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| REF 61 |
Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity. J Immunol. 2008 Jul 15;181(2):1288-98.
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| REF 62 |
Ras GTPase-activating protein-associated p62 is a major v-Src-SH3-binding protein. FEBS Lett. 1997 Feb 10;403(1):35-9.
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| REF 63 |
Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem. 2004 Aug 27;279(35):36259-67.
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| REF 64 |
Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell. 1992 May 1;69(3):551-8.
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| REF 65 |
Sam68 from an immortalised B-cell line associates with a subset of SH3 domains. FEBS Lett. 1996 Jul 1;389(2):141-4.
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| REF 66 |
A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.
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| REF 67 |
The role of SRC-CAS interactions in cellular transformation: ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation. Mol Carcinog. 1999 Sep;26(1):20-31.
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| REF 68 |
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci. 2004 Mar 15;117(Pt 8):1603-11.
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| REF 69 |
Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b. Cancer Res. 2006 Jul 15;66(14):7007-15.
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| REF 70 |
Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell. 2006 Dec 1;127(5):1015-26.
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| REF 71 |
The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. J Biol Chem. 2001 Mar 2;276(9):6061-4.
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| REF 72 |
The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 2001 Sep 21;276(38):35239-42.
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| REF 73 |
CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration. J Biol Chem. 2001 Mar 9;276(10):7327-36.
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| REF 74 |
Direct reprogramming of stem cell properties in colon cancer cells by CD44. EMBO J. 2011 Jun 24;30(15):3186-99.
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| REF 75 |
Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases. Curr Biol. 1996 Aug 1;6(8):981-8.
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| REF 76 |
Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains. J Biol Chem. 1996 Oct 18;271(42):26291-5.
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| REF 77 |
Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells. Lab Invest. 2000 Mar;80(3):387-94.
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| REF 78 |
E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal. 2014 Dec 2;7(354):rs7.
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