Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) | Literature-reported | Target Info | ||
UniProt ID | KHDR1_HUMAN | ||||
Gene Name | KHDRBS1 | ||||
Gene ID | 10657 |
Interacting TTD Target Information | Top | ||||
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Interacting Successful Target(s) | LCK tyrosine protein kinase (LCK) | Target Info | PPI Info | [1] | |
Proto-oncogene c-Src (SRC) | Target Info | PPI Info | [2] | ||
Fyn tyrosine protein kinase (FYN) | Target Info | PPI Info | [1] | ||
Interacting Clinical trial Target(s) | Yes tyrosine kinase (YES) | Target Info | PPI Info | [2] | |
Tyrosine-protein kinase Lyn (JTK8) | Target Info | PPI Info | [2] | ||
CREB-binding protein (CREBBP) | Target Info | PPI Info | [3] | ||
T-cell-specific kinase (ITK) | Target Info | PPI Info | [4] | ||
NCK adaptor protein 1 (NCK1) | Target Info | PPI Info | [5] | ||
Protein arginine methyltransferase 1 (PRMT1) | Target Info | PPI Info | [6] | ||
Interacting Literature-reported Target(s) | GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) | Target Info | PPI Info | [7] | |
GTPase activating protein (RASA1) | Target Info | PPI Info | [8] |
References | Top | ||||
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REF 1 | Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. EMBO Rep. 2006 Oct;7(10):1023-9. | ||||
REF 2 | Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. PLoS One. 2012;7(6):e38540. | ||||
REF 3 | Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68. Mol Cancer Res. 2002 Nov;1(1):48-55. | ||||
REF 4 | The proline rich region of the Tec homology domain of ITK regulates its activity. FEBS Lett. 2002 Aug 14;525(1-3):53-8. | ||||
REF 5 | The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Oncogene. 1997 Jan 16;14(2):223-31. | ||||
REF 6 | Arginine methylation regulates telomere length and stability. Mol Cell Biol. 2009 Sep;29(18):4918-34. | ||||
REF 7 | Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain. Mol Cell Biol. 1997 Oct;17(10):5707-18. | ||||
REF 8 | Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling. Mol Cell Endocrinol. 2001 Oct 25;183(1-2):113-21. |
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