Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T80395 Target Info
Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1)
Synonyms p68; p21 Ras GTPaseactivating proteinassociated p62; p21 Ras GTPase-activating protein-associated p62; Srcassociated in mitosis 68 kDa protein; Src-associated in mitosis 68 kDa protein; Sam68; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; GAPassociated tyrosine phosphoprotein p62
Target Type Literature-reported Target
Gene Name KHDRBS1
UniProt ID
KHDR1_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Protein-peptide [3]
4 Reconstituted Complex [2]
5 Yeast two hybrid [4]
Interacting Target Name NCK adaptor protein 1 (NCK1) Clinical trial Target Interacting Protein Info
UniProt ID
NCK1_HUMAN 
Synonyms SH2/SH3 adaptor protein NCK-alpha; SH2/SH3 adaptor protein NCKalpha; Nck-1; Nck1; NCK; Cytoplasmic protein NCK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Far Western [5]
3 Reconstituted Complex [6]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Phospholipase C-gamma-1 (PLCG1) Interacting Protein Interacting Protein Info
UniProt ID
PLCG1_HUMAN 
Synonyms NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [2]
Kinases [+] 7 Kinases +
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Biochemical Activity [8]
3 Fluorescence Resonance Energy Transfer [3]
4 Protein-peptide [3]
5 Reconstituted Complex [9]
6 Reconstituted Complex [2]
7 Yeast two hybrid [10]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [11]
3 Fluorescence Resonance Energy Transfer [3]
4 Protein-peptide [3]
5 Reconstituted Complex [2]
Interacting Target Name Fyn tyrosine protein kinase (FYN) Successful Target Interacting Protein Info
UniProt ID
FYN_HUMAN 
Synonyms Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Fyn Protooncogene Syn; Fyn p59-Fyn
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Biochemical Activity [8]
3 Protein-peptide [3]
4 Reconstituted Complex [13]
Interacting Target Name LCK tyrosine protein kinase (LCK) Successful Target Interacting Protein Info
UniProt ID
LCK_HUMAN 
Synonyms Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; LSK; Leukocyte C-terminal Src kinase; LCK Protooncogene Syn; LCK p59-Fyn
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Protein-peptide [15]
Interacting Target Name Yes tyrosine kinase (YES) Clinical trial Target Interacting Protein Info
UniProt ID
YES_HUMAN 
Synonyms Yes Protooncogene Syn; Yes p59-Fyn; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [8]
Interacting Target Name Tyrosine-protein kinase Lyn (JTK8) Clinical trial Target Interacting Protein Info
UniProt ID
LYN_HUMAN 
Synonyms V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p56Lyn; p53Lyn; Lck/Yes-related novel protein tyrosine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [8]
Interacting Target Name T-cell-specific kinase (ITK) Clinical trial Target Interacting Protein Info
UniProt ID
ITK_HUMAN 
Synonyms Tyrosine-protein kinase Lyk; Tyrosine-protein kinase ITK/TSK; Tyrosine kinase ITK; LYK; Kinase EMT; Interleukin-2-inducible T-cell kinase; Inducible T cell kinase; IL-2-inducible T-cell kinase; EMT
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [16]
2 Reconstituted Complex [17]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name Protein arginine methyltransferase 1 (PRMT1) Clinical trial Target Interacting Protein Info
UniProt ID
ANM1_HUMAN 
Synonyms Protein arginine N-methyltransferase 1; IR1B4; Interferon receptor 1-bound protein 4; HRMT1L2; HMT2; Histone-arginine N-methyltransferase PRMT1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Biochemical Activity [19]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Biochemical Activity [21]
3 Reconstituted Complex [20]
4 Yeast two hybrid [20]
Other proteins [+] 4 Other proteins +
Interacting Target Name GTPase activating protein (RASA1) Literature-reported Target Interacting Protein Info
UniProt ID
RASA1_HUMAN 
Synonyms RasGAP; RASA; Ras p21 protein activator; Ras GTPase-activating protein 1; p120GAP; GTPase-activating protein; GAP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Affinity Capture-Western [23]
3 Reconstituted Complex [9]
Interacting Protein Name Apoptosis-stimulating of p53 protein 1 (PPP1R13B) Interacting Protein Interacting Protein Info
UniProt ID
ASPP1_HUMAN 
Synonyms ASPP1; p53BP2.like; p85
Evidence Score (E-score) 3 Experimental Evidences +
1 Far Western [24]
2 Protein-peptide [3]
3 Yeast two hybrid [24]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein K (HNRNPK) Interacting Protein Interacting Protein Info
UniProt ID
HNRPK_HUMAN 
Synonyms CSBP; HNRPK; TUNP
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [25]
2 Yeast two hybrid [25]
3 Yeast two hybrid [26]
Interacting Protein Name Sam68-like phosphotyrosine protein (KHDRBS3) Interacting Protein Interacting Protein Info
UniProt ID
KHDR3_HUMAN 
Synonyms Etle; SALP; SLM.2; SLM2; T.STAR; TSTAR; etoile
Evidence Score (E-score) 2 Experimental Evidences +
1 Yeast two hybrid [26]
2 Yeast two hybrid [24]
References  Top
REF 1 Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nat Biotechnol. 2011 Jun 26;29(7):653-8.
REF 2 Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src. Oncogene. 1999 Aug 19;18(33):4647-53.
REF 3 Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. PLoS One. 2012;7(6):e38540.
REF 4 A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
REF 5 The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Oncogene. 1997 Jan 16;14(2):223-31.
REF 6 Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor. Oncogene. 1997 Oct 9;15(15):1823-32.
REF 7 CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation. J Immunol. 1997 Jan 1;158(1):94-103.
REF 8 Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem. 2004 Aug 27;279(35):36259-67.
REF 9 Multiple SH2-mediated interactions in v-src-transformed cells. Mol Cell Biol. 1992 Mar;12(3):1366-74.
REF 10 A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.
REF 11 Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein. J Biol Chem. 1994 Apr 29;269(17):12503-7.
REF 12 Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling. J Biol Chem. 1997 Mar 7;272(10):6214-9.
REF 13 UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. Oncogene. 2002 Mar 27;21(13):2037-50.
REF 14 Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. EMBO Rep. 2006 Oct;7(10):1023-9.
REF 15 Insights into human Lck SH3 domain binding specificity: different binding modes of artificial and native ligands. Biochemistry. 2005 Nov 15;44(45):15042-52.
REF 16 The proline rich region of the Tec homology domain of ITK regulates its activity. FEBS Lett. 2002 Aug 14;525(1-3):53-8.
REF 17 Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997 Jan 2;385(6611):93-7.
REF 18 Arginine methylation regulates telomere length and stability. Mol Cell Biol. 2009 Sep;29(18):4918-34.
REF 19 Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell. 2003 Jan;14(1):274-87.
REF 20 Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68. Mol Cancer Res. 2002 Nov;1(1):48-55.
REF 21 The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity. Oncogene. 2004 May 6;23(21):3781-9.
REF 22 Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling. Mol Cell Endocrinol. 2001 Oct 25;183(1-2):113-21.
REF 23 Sam68 association with p120GAP in CD4+ T cells is dependent on CD4 molecule expression. J Immunol. 1998 Sep 15;161(6):2798-803.
REF 24 The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo. Oncogene. 2006 May 25;25(22):3104-12.
REF 25 Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Oncogene. 2002 Oct 17;21(47):7187-94.
REF 26 Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell. 2012 Feb 24;45(4):567-80.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.