Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T91761 Target Info
Target Name T-cell-specific kinase (ITK)
Synonyms Tyrosine kinase ITK; Inducible T cell kinase; EMT
Target Type Clinical trial Target
Gene Name ITK
Biochemical Class Kinase
UniProt ID
ITK_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Phospholipase C-gamma-1 (PLCG1) Interacting Protein Interacting Protein Info
UniProt ID
PLCG1_HUMAN 
Synonyms NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Reconstituted Complex [1]
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [3]
2 Yeast two hybrid [4]
Other proteins [+] 2 Other proteins +
Interacting Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) Literature-reported Target Interacting Protein Info
UniProt ID
KHDR1_HUMAN 
Synonyms Src-associated in mitosis 68 kDa protein; Srcassociated in mitosis 68 kDa protein; Sam68; p68; p21 Ras GTPase-activating protein-associated p62; p21 Ras GTPaseactivating proteinassociated p62; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; GAPassociated tyrosine phosphoprotein p62
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [2]
2 Reconstituted Complex [5]
3 Reconstituted Complex [6]
Interacting Protein Name Lymphocyte cytosolic protein 2 (LCP2) Interacting Protein Interacting Protein Info
UniProt ID
LCP2_HUMAN 
Synonyms SLP.76; SLP76
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [7]
2 Reconstituted Complex [8]
References  Top
REF 1 Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes. J Immunol. 1999 Dec 15;163(12):6435-41.
REF 2 The proline rich region of the Tec homology domain of ITK regulates its activity. FEBS Lett. 2002 Aug 14;525(1-3):53-8.
REF 3 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 4 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 5 Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997 Jan 2;385(6611):93-7.
REF 6 Identification of Itk/Tsk Src homology 3 domain ligands. J Biol Chem. 1996 Oct 11;271(41):25646-56.
REF 7 Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities. J Med Chem. 2002 Aug 29;45(18):3905-27.
REF 8 Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem. 2000 Jan 21;275(3):2219-30.

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