Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T70977 Target Info
Target Name Glycogen synthase kinase-3 beta (GSK-3B)
Synonyms Serine/threonine-protein kinase GSK3B; GSK-3 beta
Target Type Clinical trial Target
Gene Name GSK3B
Biochemical Class Kinase
UniProt ID
GSK3B_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Target Name UNR-interacting protein (STRAP) Literature-reported Target Interacting Protein Info
UniProt ID
STRAP_HUMAN 
Synonyms WD-40 repeat protein PT-WD; UNRIP; UNR-interacting protein; MAWD; MAP activator with WD repeats
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Serine/threonine PP1-alpha (PPP1CA) Successful Target Interacting Protein Info
UniProt ID
PP1A_HUMAN 
Synonyms Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase 1alpha; PPP1A; PP-1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [8]
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [8]
2 Reconstituted Complex [9]
Kinases [+] 2 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [11]
3 Reconstituted Complex [12]
Interacting Protein Name cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) Interacting Protein Interacting Protein Info
UniProt ID
KAPCA_HUMAN 
Synonyms PKACA; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [14]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Microtubule-associated protein tau (MAPT) Clinical trial Target Interacting Protein Info
UniProt ID
TAU_HUMAN 
Synonyms tau; TAU; Paired helical filament-tau; Paired helical filamenttau; Neurofibrillary tangle protein; MTBT1; Microtubule-associated protein tau; MAPTL
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Biochemical Activity [16]
3 Biochemical Activity [9]
4 Biochemical Activity [17]
5 Biochemical Activity [18]
6 Biochemical Activity [19]
7 Biochemical Activity [20]
8 Biochemical Activity [21]
9 Biochemical Activity [22]
10 Biochemical Activity [23]
11 Biochemical Activity [24]
12 Biochemical Activity [25]
13 Reconstituted Complex [9]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ataxin-3 (ATXN3) Interacting Protein Interacting Protein Info
UniProt ID
ATX3_HUMAN 
Synonyms AT3; ATX3; JOS; MJD; MJD1; SCA3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Biochemical Activity [26]
3 Yeast two hybrid [27]
Pore-forming toxins [+] 2 Pore-forming toxins +
Interacting Target Name Amyloid beta A4 protein (APP) Successful Target Interacting Protein Info
UniProt ID
A4_HUMAN 
Synonyms Vascular beta-amyloid; Protease nexin-II; PreA4; PN-II; CVAP; Cerebral vascular amyloidpeptide; Cerebral vascular amyloid peptide; Beta-amyloid peptide; APPI; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Amyloid precursor protein; Amyloid beta precursor protein; Alzheimer's disease amyloid protein; Alzheimer disease amyloid protein; AD1; ABPP; A4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Reconstituted Complex [29]
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Yeast two hybrid [27]
Putative transporters [+] 1 Putative transporters +
Interacting Target Name LDL receptor related protein-6 (LRP-6) Clinical trial Target Interacting Protein Info
UniProt ID
LRP6_HUMAN 
Synonyms Low-density lipoprotein receptor-related protein 6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Far Western [31]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Zinc finger protein SNAI1 (SNAI1) Interacting Protein Interacting Protein Info
UniProt ID
SNAI1_HUMAN 
Synonyms SLUGH2; SNA; SNAH; SNAIL; SNAIL1; dJ710H13.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Affinity Capture-Western [33]
3 Biochemical Activity [32]
Interacting Protein Name Zinc finger protein SNAI2 (SNAI2) Interacting Protein Interacting Protein Info
UniProt ID
SNAI2_HUMAN 
Synonyms SLUG; SLUGH1; SNAIL2; WS2D
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Biochemical Activity [35]
3 Biochemical Activity [34]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [36]
2 Co-localization [37]
Other proteins [+] 9 Other proteins +
Interacting Protein Name Axin-1 (AXIN1) Interacting Protein Interacting Protein Info
UniProt ID
AXIN1_HUMAN 
Synonyms AXIN; PPP1R49
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [38]
2 Affinity Capture-MS [13]
3 Affinity Capture-Western [39]
4 Affinity Capture-Western [40]
5 Affinity Capture-Western [41]
6 Affinity Capture-Western [28]
7 Affinity Capture-Western [4]
8 Affinity Capture-Western [42]
9 Affinity Capture-Western [43]
10 Co-localization [37]
11 Reconstituted Complex [39]
12 Yeast two hybrid [39]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [44]
3 Affinity Capture-Western [40]
4 Biochemical Activity [45]
5 Biochemical Activity [46]
6 Biochemical Activity [41]
7 Biochemical Activity [47]
8 Biochemical Activity [48]
9 Biochemical Activity [49]
10 Biochemical Activity [31]
11 Co-localization [37]
Interacting Target Name MTOR complex 2 (RICTOR) Literature-reported Target Interacting Protein Info
UniProt ID
RICTR_HUMAN 
Synonyms Rapamycin-insensitive companion of mTOR; KIAA1999; hAVO3; AVO3 homolog
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [47]
2 Biochemical Activity [50]
3 Biochemical Activity [47]
Interacting Protein Name A-kinase anchor protein 11 (AKAP11) Interacting Protein Interacting Protein Info
UniProt ID
AKA11_HUMAN 
Synonyms AKAP.11; AKAP220; PPP1R44; PRKA11
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [6]
3 Yeast two hybrid [6]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Biochemical Activity [51]
3 Co-localization [37]
Interacting Target Name Mucin-1 (MUC1) Clinical trial Target Interacting Protein Info
UniProt ID
MUC1_HUMAN 
Synonyms Tumour-associated antigen mucin 1; Tumor-associated mucin; Tumor-associated epithelial membraneantigen; Tumor-associated epithelial membrane antigen; PUM; Polymorphic epithelial mucin; PEMT; PEM; Peanut-reactive urinary mucin; Mucin-1; MUC-1; Krebs von den Lungen-6; KL-6; H23AG; Episialin; EMA; CD227 antigen; CD227; Carcinoma-associated mucin; Cancer antigen 15-3; CA 15-3; Breast carcinoma-associated antigen DF3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Reconstituted Complex [52]
Interacting Protein Name Adenomatous polyposis coli protein (APC) Interacting Protein Interacting Protein Info
UniProt ID
APC_HUMAN 
Synonyms BTPS2; DP2; DP2.5; DP3; GS; PPP1R46
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [53]
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Reconstituted Complex [41]
Interacting Protein Name Tuberin (TSC2) Interacting Protein Interacting Protein Info
UniProt ID
TSC2_HUMAN 
Synonyms LAM; PPP1R160; TSC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Biochemical Activity [55]
References  Top
REF 1 XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3. Cell Signal. 2009 Dec;21(12):1857-65.
REF 2 Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. J Cell Sci. 2018 May 22;131(10). pii: jcs210575.
REF 3 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 4 Role of STRAP in regulating GSK3 function and Notch3 stabilization. Cell Cycle. 2011 May 15;10(10):1639-54.
REF 5 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 6 A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3... J Biol Chem. 2002 Oct 4;277(40):36955-61.
REF 7 Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. Biochim Biophys Acta. 2009 Oct;1793(10):1597-603.
REF 8 C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances. Oncogene. 2013 Jun 20;32(25):3101-10.
REF 9 Stimulatory effect of -synuclein on the tau-phosphorylation by GSK-3. FEBS J. 2011 Dec;278(24):4895-904.
REF 10 Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. 2011 Jan 27;30(4):457-70.
REF 11 Purification and characterization of recombinant CH3 domain fragment of the CREB-binding protein. Protein Expr Purif. 2010 Apr;70(2):196-205.
REF 12 Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J Biol Chem. 2005 Sep 9;280(36):31924-35.
REF 13 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 14 Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11960-5.
REF 15 NUB1 modulation of GSK3 reduces tau aggregation. Hum Mol Genet. 2012 Dec 15;21(24):5254-67.
REF 16 CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem. 2004 Feb 6;279(6):4869-76.
REF 17 Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase. FEBS Lett. 1998 Sep 25;436(1):28-34.
REF 18 Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry. 1999 Mar 23;38(12):3549-58.
REF 19 Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation. Eur J Biochem. 1998 Mar 15;252(3):542-52.
REF 20 Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily. FEBS Lett. 2007 Jun 12;581(14):2657-62.
REF 21 Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Lett. 2002 Oct 23;530(1-3):209-14.
REF 22 Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. J Neurochem. 2009 Jan;108(1):33-43.
REF 23 Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains. FEBS Lett. 2009 Jul 7;583(13):2194-200.
REF 24 PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners. FEBS Lett. 2006 Nov 13;580(26):6269-74.
REF 25 Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7951-5.
REF 26 Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3. Biochem Biophys Res Commun. 2007 Jun 1;357(2):487-92.
REF 27 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 28 The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth. Biochim Biophys Acta. 2012 Aug;1823(8):1233-41.
REF 29 Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. J Biol Chem. 2011 Sep 30;286(39):34088-100.
REF 30 Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell. 2006 Aug;11(2):213-23.
REF 31 Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One. 2008;3(12):e4046.
REF 32 Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol. 2004 Oct;6(10):931-40.
REF 33 Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell. 2009 May 5;15(5):416-28.
REF 34 GSK3 controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene. 2014 Jun 12;33(24):3172-82.
REF 35 Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16654-9.
REF 36 PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells. Mol Biol Cell. 2007 Mar;18(3):1118-27.
REF 37 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 38 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 39 Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells. 1998 Jun;3(6):395-403.
REF 40 An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J. 1999 May 4;18(9):2401-10.
REF 41 Induction of Gsk3--TrCP interaction is required for late phase stabilization of -catenin in canonical Wnt signaling. J Biol Chem. 2014 Mar 7;289(10):7099-108.
REF 42 Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1). J Biol Chem. 2003 Apr 18;278(16):13995-4001.
REF 43 The SIAH E3 ubiquitin ligases promote Wnt/-catenin signaling through mediating Wnt-induced Axin degradation. Genes Dev. 2017 May 1;31(9):904-915.
REF 44 Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis. J Cell Biochem. 2002;84(4):816-31.
REF 45 DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol Cell Biol. 1999 Jun;19(6):4414-22.
REF 46 The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol. 1999 Feb 25;9(4):207-10.
REF 47 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. J Biol Chem. 2015 May 29;290(22):14120-9.
REF 48 APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. Mol Cell. 2008 Dec 5;32(5):652-61.
REF 49 Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell. 2005 Jul 22;19(2):159-70.
REF 50 ER stress inhibits mTORC2 and Akt signaling through GSK-3-mediated phosphorylation of rictor. Sci Signal. 2011 Feb 22;4(161):ra10.
REF 51 GSK-3 controls NF-kappaB activity via IKK/NEMO. Sci Rep. 2016 Dec 8;6:38553.
REF 52 The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. J Biol Chem. 2001 Mar 2;276(9):6061-4.
REF 53 The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction p... Int J Oncol. 2001 Apr;18(4):843-7.
REF 54 The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. J Biol Chem. 2003 Feb 21;278(8):5947-51.
REF 55 TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006 Sep 8;126(5):955-68.

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