Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T03644 Target Info
Target Name Synuclein alpha (SNCA)
Synonyms PARK1; Non-A4 component of amyloid precursor; Non-A beta component of AD amyloid; NACP; Alpha-synuclein
Target Type Clinical trial Target
Gene Name SNCA
Biochemical Class Synuclein
UniProt ID
SYUA_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase parkin (PRKN) Interacting Protein Interacting Protein Info
UniProt ID
PRKN_HUMAN 
Synonyms AR.JP; LPRS2; PDJ; PRKN
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Heat shock proteins [+] 4 Heat shock proteins +
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Protein-peptide [4]
3 Reconstituted Complex [5]
Interacting Protein Name Alpha-crystallin B chain (CRYAB) Interacting Protein Interacting Protein Info
UniProt ID
CRYAB_HUMAN 
Synonyms CMD1II; CRYA2; CTPP2; CTRCT16; HEL.S.101; HSPB5; MFM2
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [6]
2 Reconstituted Complex [6]
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [8]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [9]
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [10]
2 Protein-Fragment Complementation Assay [10]
3 Yeast two hybrid [11]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Microtubule-associated protein tau (MAPT) Clinical trial Target Interacting Protein Info
UniProt ID
TAU_HUMAN 
Synonyms tau; TAU; Paired helical filament-tau; Paired helical filamenttau; Neurofibrillary tangle protein; MTBT1; Microtubule-associated protein tau; MAPTL
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Co-localization [13]
3 Reconstituted Complex [14]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Clinical trial Target Interacting Protein Info
UniProt ID
G3P_HUMAN 
Synonyms Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [15]
2 Yeast two hybrid [16]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Amyloid beta A4 protein (APP) Successful Target Interacting Protein Info
UniProt ID
A4_HUMAN 
Synonyms Vascular beta-amyloid; Protease nexin-II; PreA4; PN-II; CVAP; Cerebral vascular amyloidpeptide; Cerebral vascular amyloid peptide; Beta-amyloid peptide; APPI; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Amyloid precursor protein; Amyloid beta precursor protein; Alzheimer's disease amyloid protein; Alzheimer disease amyloid protein; AD1; ABPP; A4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Co-localization [18]
3 Reconstituted Complex [19]
Porters [+] 2 Porters +
Interacting Target Name Serotonin transporter (SERT) Successful Target Interacting Protein Info
UniProt ID
SC6A4_HUMAN 
Synonyms Solute carrier family 6 member 4; HTT; 5HTT; 5HT transporter
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Co-localization [20]
Interacting Target Name Dopamine transporter (DAT) Successful Target Interacting Protein Info
UniProt ID
SC6A3_HUMAN 
Synonyms Solute carrier family 6 member 3; Sodium-dependent dopamine transporter; DAT1; DAT; DA transporter
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Yeast two hybrid [22]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Fluorescence Resonance Energy Transfer [23]
Other proteins [+] 5 Other proteins +
Interacting Protein Name Synphilin-1 (SNCAIP) Interacting Protein Interacting Protein Info
UniProt ID
SNCAP_HUMAN 
Synonyms SYPH1; Sph1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Co-crystal Structure [25]
3 Reconstituted Complex [26]
4 Yeast two hybrid [26]
Interacting Target Name Spectrin non-erythroid beta chain 1 (SPTBN1) Clinical trial Target Interacting Protein Info
UniProt ID
SPTB2_HUMAN 
Synonyms SPTB2; Spectrin, non-erythroid beta chain 1; Spectrin beta chain, non-erythrocytic 1; Fodrin beta chain; Beta-II spectrin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Co-localization [28]
3 Reconstituted Complex [28]
Interacting Protein Name Tubulin alpha-1B chain (TUBA1B) Interacting Protein Interacting Protein Info
UniProt ID
TBA1B_HUMAN 
Synonyms K.ALPHA.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Affinity Capture-Western [29]
3 Protein-peptide [4]
Interacting Target Name Alpha-endosulfine (ENSA) Literature-reported Target Interacting Protein Info
UniProt ID
ENSA_HUMAN 
Synonyms ENSA; ARPP19e
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [4]
2 Reconstituted Complex [4]
Interacting Protein Name Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Interacting Protein Interacting Protein Info
UniProt ID
DYHC1_HUMAN 
Synonyms DHC1; DHC1a; DNCH1; DNCL; DNECL; DYHC; Dnchc1; HL.3; SMALED1; p22
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Protein-peptide [4]
References  Top
REF 1 Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodies. J Biol Chem. 2009 Oct 2;284(40):27252-64.
REF 2 Co-association of parkin and alpha-synuclein. Neuroreport. 2001 Sep 17;12(13):2839-43.
REF 3 Phosphorylation of -synuclein is crucial in compensating for proteasomal dysfunction. Biochem Biophys Res Commun. 2012 Aug 3;424(3):597-603.
REF 4 Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. J Biol Chem. 2007 Nov 23;282(47):34555-67.
REF 5 Identification of protein interfaces between -synuclein, the principal component of Lewy bodies in Parkinson disease, and the molecular chaperones human Hsc70 and the yeast Ssa1p. J Biol Chem. 2012 Sep 21;287(39):32630-9.
REF 6 Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity. J Mol Biol. 2004 Jul 23;340(5):1167-83.
REF 7 Ubiquitinylation of -synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). PLoS One. 2011 Feb 16;6(2):e14695.
REF 8 Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates. J Mol Biol. 2006 Dec 1;364(3):323-36.
REF 9 Inhibition of -synuclein aggregation by small heat shock proteins. Proteins. 2011 Oct;79(10):2956-67.
REF 10 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 11 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 12 Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation. Exp Cell Res. 2005 Aug 1;308(1):78-84.
REF 13 alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton. Neurobiol Dis. 2007 Jun;26(3):521-31.
REF 14 alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem. 1999 Sep 3;274(36):25481-9.
REF 15 Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions. Eur J Neurosci. 2005 Jan;21(2):317-26.
REF 16 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 17 Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 4;3(9):e3135.
REF 18 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 19 NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta ... Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9141-5.
REF 20 Partial regulation of serotonin transporter function by gamma-synuclein. Neurosci Lett. 2009 Apr 10;453(3):157-61.
REF 21 Attenuation of dopamine transporter activity by alpha-synuclein. Neurosci Lett. 2003 Apr 17;340(3):189-92.
REF 22 Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J. 2001 Apr;15(6):916-26.
REF 23 Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies. Acta Neuropathol. 2001 Oct;102(4):329-34.
REF 24 Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells. J Neurosci. 2005 Jun 8;25(23):5544-52.
REF 25 Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication. FASEB J. 2010 Jan;24(1):196-205.
REF 26 Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat Genet. 1999 May;22(1):110-4.
REF 27 Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. Mol Cell Proteomics. 2008 Nov;7(11):2123-37.
REF 28 -Synuclein modulates neurite outgrowth by interacting with SPTBN1. Biochem Biophys Res Commun. 2012 Aug 3;424(3):497-502.
REF 29 Tubulin seeds alpha-synuclein fibril formation. J Biol Chem. 2002 Jan 18;277(3):2112-7.
REF 30 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.

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