Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T71525 Target Info
Target Name Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1)
Synonyms Protein HEXIM1; Menage a quatre protein 1; MAQ1; HIS1; Estrogen down-regulated gene 1 protein; EDG1; Cardiac lineage protein 1; CLP1
Target Type Literature-reported Target
Gene Name HEXIM1
UniProt ID
HEXI1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name ATP-dependent RNA helicase A (DHX9) Interacting Protein Interacting Protein Info
UniProt ID
DHX9_HUMAN 
Synonyms DDX9; LKP; NDH2; NDHII; RHA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E2/E3 hybrid ubiquitin-protein ligase UBE2O (UBE2O) Interacting Protein Interacting Protein Info
UniProt ID
UBE2O_HUMAN 
Synonyms E2.230K
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Co-fractionation [1]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [4]
Cell cycle related proteins [+] 2 Cell cycle related proteins +
Interacting Protein Name Cyclin-T1 (CCNT1) Interacting Protein Interacting Protein Info
UniProt ID
CCNT1_HUMAN 
Synonyms CCNT; CYCT1; HIVE1
Evidence Score (E-score) 17 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [6]
5 Affinity Capture-Western [7]
6 Affinity Capture-Western [8]
7 Affinity Capture-Western [9]
8 Affinity Capture-Western [6]
9 Affinity Capture-Western [10]
10 Affinity Capture-Western [11]
11 Affinity Capture-Western [12]
12 Affinity Capture-Western [13]
13 Affinity Capture-Western [1]
14 Affinity Capture-Western [14]
15 Reconstituted Complex [7]
16 Reconstituted Complex [13]
17 Yeast two hybrid [11]
Interacting Protein Name Cyclin-T2 (CCNT2) Interacting Protein Interacting Protein Info
UniProt ID
CCNT2_HUMAN 
Synonyms CYCT2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [3]
4 Yeast two hybrid [11]
Kinases [+] 1 Kinases +
Interacting Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Interacting Protein Info
UniProt ID
CDK9_HUMAN 
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K
Evidence Score (E-score) 16 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [6]
5 Affinity Capture-Western [12]
6 Affinity Capture-Western [8]
7 Affinity Capture-Western [9]
8 Affinity Capture-Western [6]
9 Affinity Capture-Western [10]
10 Affinity Capture-Western [15]
11 Affinity Capture-Western [11]
12 Affinity Capture-Western [13]
13 Affinity Capture-Western [1]
14 Affinity Capture-Western [16]
15 Reconstituted Complex [13]
16 Reconstituted Complex [6]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Protein Name Bicoid-interacting protein 3 homolog (MEPCE) Interacting Protein Interacting Protein Info
UniProt ID
MEPCE_HUMAN 
Synonyms BCDIN3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [1]
Putative transporters [+] 1 Putative transporters +
Interacting Protein Name AP-1 complex subunit mu-1 (AP1M1) Interacting Protein Interacting Protein Info
UniProt ID
AP1M1_HUMAN 
Synonyms AP47; CLAPM2; CLTNM; MU.1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [17]
Other proteins [+] 1 Other proteins +
Interacting Protein Name La-related protein 7 (LARP7) Interacting Protein Interacting Protein Info
UniProt ID
LARP7_HUMAN 
Synonyms ALAZS; PIP7S
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [6]
5 Affinity Capture-Western [1]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [6]
8 Reconstituted Complex [6]
References  Top
REF 1 The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife. 2018 May 30;7. pii: e31879.
REF 2 RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol Cell. 2007 May 25;26(4):523-37.
REF 3 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 4 HEXIM1 down-regulates hypoxia-inducible factor-1 protein stability. Biochem J. 2013 Dec 1;456(2):195-204.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. EMBO Rep. 2008 Jun;9(6):569-75.
REF 7 The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1. Oncogene. 2005 Aug 25;24(36):5576-88.
REF 8 Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell. 2005 Aug 19;19(4):535-45.
REF 9 AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E15-24.
REF 10 Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. Mol Cell. 2003 Oct;12(4):971-82.
REF 11 MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. Mol Cell Biol. 2003 Jul;23(14):4859-69.
REF 12 A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. Mol Cell Biol. 2004 Jun;24(12):5094-105.
REF 13 Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. EMBO J. 2004 Jul 7;23(13):2608-19.
REF 14 Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat. J Biol Chem. 2005 Jul 1;280(26):24968-77.
REF 15 Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. J Biol Chem. 2005 Apr 22;280(16):16368-76.
REF 16 Identification of HEXIM1 as a positive regulator of p53. J Biol Chem. 2012 Oct 19;287(43):36443-54.
REF 17 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.

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