Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T63743 Target Info
Target Name Structural maintenance of chromosomes protein 2 (SMC2)
Synonyms hCAP-E; XCAP-E homolog; SMC2L1; SMC-2; SMC protein 2; PRO0324; Chromosome-associated protein E; CAPE
Target Type Literature-reported Target
Gene Name SMC2
UniProt ID
SMC2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Structural maintenance of chromosomes protein 4 (SMC4) Interacting Protein Interacting Protein Info
UniProt ID
SMC4_HUMAN 
Synonyms CAP.C; CAPC; SMC.4; SMC4L1; hCAP.C
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Co-fractionation [4]
5 Co-fractionation [5]
6 Co-fractionation [6]
Condensins [+] 4 Condensins +
Interacting Protein Name Condensin complex subunit 1 (NCAPD2) Interacting Protein Interacting Protein Info
UniProt ID
CND1_HUMAN 
Synonyms CAP.D2; CNAP1; hCAP.D2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [2]
3 Co-fractionation [4]
4 Co-fractionation [5]
Interacting Protein Name Condensin complex subunit 2 (NCAPH) Interacting Protein Interacting Protein Info
UniProt ID
CND2_HUMAN 
Synonyms BRRN1; CAP.H
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [2]
3 Co-fractionation [4]
4 Co-fractionation [5]
Interacting Protein Name Condensin complex subunit 3 (NCAPG) Interacting Protein Interacting Protein Info
UniProt ID
CND3_HUMAN 
Synonyms CAPG; CHCG; NY.MEL.3; YCG1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [2]
3 Co-fractionation [4]
Interacting Protein Name Condensin-2 complex subunit H2 (NCAPH2) Interacting Protein Interacting Protein Info
UniProt ID
CNDH2_HUMAN 
Synonyms CAPH2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [2]
3 Co-fractionation [4]
Kinases [+] 2 Kinases +
Interacting Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Interacting Protein Info
UniProt ID
CDK9_HUMAN 
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Co-fractionation [5]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [8]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Condensin-2 complex subunit D3 (NCAPD3) Interacting Protein Interacting Protein Info
UniProt ID
CNDD3_HUMAN 
Synonyms CAP.D3; CAPD3; hCAP.D3; hHCP.6; hcp.6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [2]
3 Co-fractionation [4]
Interacting Protein Name Condensin-2 complex subunit G2 (NCAPG2) Interacting Protein Interacting Protein Info
UniProt ID
CNDG2_HUMAN 
Synonyms CAP.G2; CAPG2; LUZP5; MTB; hCAP.G2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [2]
3 Co-fractionation [4]
References  Top
REF 1 Wapl controls the dynamic association of cohesin with chromatin. Cell. 2006 Dec 1;127(5):955-67.
REF 2 Condensin I and II Complexes License Full Estrogen Receptor -Dependent Enhancer Activation. Mol Cell. 2015 Jul 16;59(2):188-202.
REF 3 Reconstitution and subunit geometry of human condensin complexes. EMBO J. 2007 Feb 21;26(4):1024-34.
REF 4 Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell. 2003 Oct 3;115(1):109-21.
REF 5 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 6 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 7 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 8 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Mol Cell Proteomics. 2014 Jul;13(7):1644-58.

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