Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T44458 Target Info
Target Name Cyclin-dependent kinase 9 (CDK9)
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2L4; CDC2-related kinase; C-2K
Target Type Clinical trial Target
Gene Name CDK9
Biochemical Class Kinase
UniProt ID
CDK9_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Structural maintenance of chromosomes protein 2 (SMC2) Literature-reported Target Interacting Protein Info
UniProt ID
SMC2_HUMAN 
Synonyms XCAP-E homolog; SMC2L1; SMC-2; SMC protein 2; PRO0324; hCAP-E; Chromosome-associated protein E; CAPE
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Structural maintenance of chromosomes protein 4 (SMC4) Interacting Protein Interacting Protein Info
UniProt ID
SMC4_HUMAN 
Synonyms CAP.C; CAPC; SMC.4; SMC4L1; hCAP.C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Cell cycle related proteins [+] 2 Cell cycle related proteins +
Interacting Protein Name Cyclin-T1 (CCNT1) Interacting Protein Interacting Protein Info
UniProt ID
CCNT1_HUMAN 
Synonyms CCNT; CYCT1; HIVE1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [5]
5 Affinity Capture-MS [6]
6 Affinity Capture-MS [7]
7 Affinity Capture-MS [8]
8 Affinity Capture-MS [9]
9 Affinity Capture-MS [10]
10 Affinity Capture-Western [11]
11 Affinity Capture-Western [12]
12 Affinity Capture-Western [13]
13 Affinity Capture-Western [14]
14 Affinity Capture-Western [15]
15 Affinity Capture-Western [16]
16 Affinity Capture-Western [10]
17 Affinity Capture-Western [17]
18 Affinity Capture-Western [18]
19 Affinity Capture-Western [19]
20 Affinity Capture-Western [20]
Interacting Protein Name Cyclin-T2 (CCNT2) Interacting Protein Interacting Protein Info
UniProt ID
CCNT2_HUMAN 
Synonyms CYCT2
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [5]
5 Affinity Capture-MS [6]
6 Affinity Capture-MS [7]
7 Affinity Capture-MS [8]
8 Affinity Capture-Western [17]
9 Co-crystal Structure [21]
10 Co-fractionation [22]
11 Co-fractionation [23]
12 Reconstituted Complex [17]
13 Reconstituted Complex [24]
Cell division cycle proteins [+] 2 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [6]
5 Affinity Capture-MS [9]
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Biochemical Activity [26]
3 Biochemical Activity [27]
4 Biochemical Activity [28]
5 Co-fractionation [26]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name DNA mismatch repair protein MSH2 (MSH2) Literature-reported Target Interacting Protein Info
UniProt ID
MSH2_HUMAN 
Synonyms MutS protein homolog 2; Mismatch repair gene Msh2; hMSH2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [9]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [6]
5 Affinity Capture-MS [9]
Isomerases [+] 1 Isomerases +
Interacting Target Name FK506-binding protein 5 (FKBP5) Literature-reported Target Interacting Protein Info
UniProt ID
FKBP5_HUMAN 
Synonyms PPIase FKBP5; Peptidyl-prolyl cis-trans isomerase FKBP5; HSP90-binding immunophilin; FKBP54; FKBP-51; FKBP51; FKBP-5; FF1 antigen; Androgen-regulated protein 6; AIG6; 54 kDa progesterone receptor-associated immunophilin; 51 kDa FKBP; 51 kDa FK506-binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [29]
2 Affinity Capture-MS [30]
Kinases [+] 2 Kinases +
Interacting Protein Name DNA-directed RNA polymerase II subunit RPB1 (POLR2A) Interacting Protein Interacting Protein Info
UniProt ID
RPB1_HUMAN 
Synonyms POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Biochemical Activity [32]
3 Biochemical Activity [33]
4 Biochemical Activity [34]
5 Biochemical Activity [35]
6 Biochemical Activity [36]
7 Biochemical Activity [18]
8 Biochemical Activity [37]
9 Biochemical Activity [38]
10 Biochemical Activity [21]
11 Biochemical Activity [39]
12 Biochemical Activity [40]
13 Biochemical Activity [41]
14 Biochemical Activity [42]
15 Biochemical Activity [43]
16 Biochemical Activity [44]
17 Biochemical Activity [45]
18 Biochemical Activity [46]
19 Biochemical Activity [47]
20 Co-fractionation [48]
Interacting Protein Name Casein kinase II subunit beta (CSNK2B) Interacting Protein Interacting Protein Info
UniProt ID
CSK2B_HUMAN 
Synonyms CK2B; CK2N; CSK2B; G5A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [49]
Ligases [+] 1 Ligases +
Interacting Protein Name Methionyl-tRNA synthetase (MARS) Interacting Protein Interacting Protein Info
UniProt ID
SYMC_HUMAN 
Synonyms METRS; MRS; MTRNS; SPG70
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [9]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Protein Name Bicoid-interacting protein 3 homolog (MEPCE) Interacting Protein Interacting Protein Info
UniProt ID
MEPCE_HUMAN 
Synonyms BCDIN3
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [5]
5 Affinity Capture-MS [6]
6 Affinity Capture-MS [7]
7 Affinity Capture-Western [13]
Putative transporters [+] 1 Putative transporters +
Interacting Protein Name MICOS complex subunit MIC60 (IMMT) Interacting Protein Interacting Protein Info
UniProt ID
MIC60_HUMAN 
Synonyms HMP; MINOS2; P87; P87/89; P89; PIG52
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [50]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) Literature-reported Target Interacting Protein Info
UniProt ID
HEXI1_HUMAN 
Synonyms Protein HEXIM1; Menage a quatre 1; MAQ1; Likely ortholog of mouse cardiac lineage protein 1; HIS1 protein; HIS1; Hexamethylene bis-acetamide-inducible protein 1; Estrogen down-regulated gene 1 protein; CLP1; Cardiac lineage protein 1
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [7]
4 Affinity Capture-MS [10]
5 Affinity Capture-Western [18]
6 Affinity Capture-Western [12]
7 Affinity Capture-Western [13]
8 Affinity Capture-Western [15]
9 Affinity Capture-Western [16]
10 Affinity Capture-Western [10]
11 Affinity Capture-Western [38]
12 Affinity Capture-Western [51]
13 Reconstituted Complex [18]
Interacting Protein Name AF4/FMR2 family member 1 (AFF1) Interacting Protein Interacting Protein Info
UniProt ID
AFF1_HUMAN 
Synonyms AF4; MLLT2; PBM1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [5]
5 Affinity Capture-MS [6]
6 Affinity Capture-MS [8]
7 Affinity Capture-Western [14]
8 Affinity Capture-Western [13]
Interacting Protein Name AF4/FMR2 family member 4 (AFF4) Interacting Protein Interacting Protein Info
UniProt ID
AFF4_HUMAN 
Synonyms AF5Q31; MCEF
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [5]
4 Affinity Capture-MS [6]
5 Affinity Capture-MS [7]
6 Affinity Capture-Western [31]
7 Affinity Capture-Western [14]
8 Affinity Capture-Western [15]
Interacting Protein Name Protein HEXIM2 (HEXIM2) Interacting Protein Interacting Protein Info
UniProt ID
HEXI2_HUMAN 
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [7]
5 Affinity Capture-Western [38]
6 Affinity Capture-Western [51]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Reconstituted Complex [53]
Translocases [+] 1 Translocases +
Interacting Target Name Sodium pump subunit alpha-1 (ATP1A1) Successful Target Interacting Protein Info
UniProt ID
AT1A1_HUMAN 
Synonyms Sodium/potassium-transporting ATPase alpha1; Sodium pump 1; Na+/K+ ATPase 1; ATP1A1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [9]
Other proteins [+] 10 Other proteins +
Interacting Protein Name YEATS domain-containing protein 1 (MLLT1) Interacting Protein Interacting Protein Info
UniProt ID
ENL_HUMAN 
Synonyms ENL; LTG19; YEATS1
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [5]
5 Affinity Capture-MS [6]
6 Affinity Capture-MS [8]
7 Affinity Capture-Western [31]
8 Affinity Capture-Western [14]
9 Affinity Capture-Western [15]
Interacting Protein Name La-related protein 7 (LARP7) Interacting Protein Interacting Protein Info
UniProt ID
LARP7_HUMAN 
Synonyms ALAZS; PIP7S
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [5]
5 Affinity Capture-MS [6]
6 Affinity Capture-MS [7]
7 Affinity Capture-MS [10]
8 Affinity Capture-Western [13]
9 Affinity Capture-Western [10]
Interacting Protein Name YEATS domain-containing protein 3 (MLLT3) Interacting Protein Interacting Protein Info
UniProt ID
AF9_HUMAN 
Synonyms AF9; YEATS3
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [5]
5 Affinity Capture-MS [6]
6 Affinity Capture-MS [8]
7 Affinity Capture-Western [31]
Interacting Protein Name Transcription elongation factor SPT5 (SUPT5H) Interacting Protein Interacting Protein Info
UniProt ID
SPT5H_HUMAN 
Synonyms SPT5; SPT5H; Tat.CT1
Evidence Score (E-score) 5 Experimental Evidences +
1 Biochemical Activity [54]
2 Biochemical Activity [55]
3 Biochemical Activity [39]
4 Biochemical Activity [56]
5 Reconstituted Complex [39]
Interacting Protein Name RNA polymerase II elongation factor ELL2 (ELL2) Interacting Protein Interacting Protein Info
UniProt ID
ELL2_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [31]
4 Affinity Capture-Western [15]
Interacting Target Name Bromodomain-containing protein 4 (BRD4) Clinical trial Target Interacting Protein Info
UniProt ID
BRD4_HUMAN 
Synonyms Protein HUNK1; HUNK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [12]
3 Affinity Capture-Western [16]
Interacting Protein Name RNA polymerase II-associated factor 1 homolog (PAF1) Interacting Protein Interacting Protein Info
UniProt ID
PAF1_HUMAN 
Synonyms F23149_1; PD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Co-fractionation [48]
Interacting Protein Name Ribophorin I (RPN1) Interacting Protein Interacting Protein Info
UniProt ID
RPN1_HUMAN 
Synonyms OST1; RBPH1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [9]
Interacting Protein Name General transcription factor IIF subunit 1 (GTF2F1) Interacting Protein Interacting Protein Info
UniProt ID
T2FA_HUMAN 
Synonyms BTF4; RAP74; TF2F1; TFIIF
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [40]
2 Co-fractionation [57]
Interacting Protein Name T-complex protein 1 subunit theta (CCT8) Interacting Protein Interacting Protein Info
UniProt ID
TCPQ_HUMAN 
Synonyms C21orf112; Cctq; D21S246; PRED71
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [9]
References  Top
REF 1 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 2 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 5 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 6 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 7 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell. 2007 Jul 20;27(2):262-74.
REF 8 Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell. 2011 Jul 8;146(1):92-104.
REF 9 A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics. 2010 May;9(5):811-23.
REF 10 The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. EMBO Rep. 2008 Jun;9(6):569-75.
REF 11 The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature. 2001 Nov 15;414(6861):317-22.
REF 12 Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell. 2005 Aug 19;19(4):535-45.
REF 13 AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E15-24.
REF 14 A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell. 2010 Feb 17;17(2):198-212.
REF 15 The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. Mol Cell. 2012 May 11;46(3):325-34.
REF 16 Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation. Mol Cell Biol. 2006 Oct;26(19):7068-76.
REF 17 Identification of multiple cyclin subunits of human P-TEFb. Genes Dev. 1998 Mar 1;12(5):755-62.
REF 18 Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. Mol Cell. 2003 Oct;12(4):971-82.
REF 19 The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. J Cell Sci. 2001 Apr;114(Pt 8):1491-503.
REF 20 Functional inactivation of Cdk9 through oligomerization chain reaction. Oncogene. 2003 Jul 31;22(31):4882-8.
REF 21 The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. EMBO J. 2008 Jul 9;27(13):1907-18.
REF 22 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 23 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature. 2001 Nov 15;414(6861):322-5.
REF 24 The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. AIDS. 1999 Aug 20;13(12):1453-9.
REF 25 Physical interaction between pRb and cdk9/cyclinT2 complex. Oncogene. 2002 Jun 13;21(26):4158-65.
REF 26 The CDC2-related kinase PITALRE is the catalytic subunit of active multimeric protein complexes. Biochem J. 1996 Oct 1;319 ( Pt 1):293-8.
REF 27 CDC2-related kinase PITALRE phosphorylates pRb exclusively on serine and is widely expressed in human tissues. J Cell Physiol. 1997 Aug;172(2):265-73.
REF 28 PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3834-8.
REF 29 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 30 USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling. EMBO J. 2017 May 15;36(10):1434-1446.
REF 31 Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):E636-45.
REF 32 The BRCA1 COOH-terminal region acts as an RNA polymerase II carboxyl-terminal domain kinase inhibitor that modulates p21WAF1/CIP1 expression. J Biol Chem. 2006 Jul 28;281(30):21119-30.
REF 33 A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1. Biol Proced Online. 2004;6:163-172.
REF 34 Retroviral cyclin enhances cyclin-dependent kinase-8 activity. J Virol. 2012 May;86(10):5742-51.
REF 35 Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II. Eur J Biochem. 2004 Mar;271(5):1004-14.
REF 36 Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences. J Biol Chem. 2001 Apr 6;276(14):10913-20.
REF 37 Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA. J Biol Chem. 2004 Feb 6;279(6):4153-60.
REF 38 Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. J Biol Chem. 2005 Apr 22;280(16):16368-76.
REF 39 Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat Struct Mol Biol. 2012 Nov;19(11):1108-15.
REF 40 The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2328-33.
REF 41 The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures. Leukemia. 2011 Jan;25(1):135-44.
REF 42 TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5367-72.
REF 43 A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat. Virology. 2002 Apr 25;296(1):6-16.
REF 44 Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. Mol Cell Biol. 2002 Jul;22(13):4622-37.
REF 45 CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2. Mol Cell Biol. 2003 Aug;23(15):5165-73.
REF 46 Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function. Cell Cycle. 2012 Jun 1;11(11):2122-7.
REF 47 A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. Mol Cell Biol. 2004 Jun;24(12):5094-105.
REF 48 H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb. Mol Cell. 2014 Jun 19;54(6):920-931.
REF 49 Cdk9 phosphorylates p53 on serine 392 independently of CKII. J Cell Physiol. 2006 Sep;208(3):602-12.
REF 50 Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. EMBO J. 1997 May 15;16(10):2836-50.
REF 51 HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. J Biol Chem. 2005 Apr 22;280(16):16360-7.
REF 52 c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene. 2003 Aug 28;22(36):5707-11.
REF 53 c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem. 2001 Dec 21;276(51):48562-71.
REF 54 Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol. 2006 Jan;13(1):55-62.
REF 55 CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. Mol Cell Biol. 2000 Sep;20(18):6958-69.
REF 56 Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. EMBO J. 2004 Jul 7;23(13):2608-19.
REF 57 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.

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