Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T40556 Target Info
Target Name Bromodomain-containing protein 4 (BRD4)
Synonyms Protein HUNK1; HUNK1
Target Type Clinical trial Target
Gene Name BRD4
Biochemical Class Bromodomain
UniProt ID
BRD4_HUMAN 
Target Interacting Proteins  Top
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Protein Name Cyclin-T1 (CCNT1) Interacting Protein Interacting Protein Info
UniProt ID
CCNT1_HUMAN 
Synonyms CCNT; CYCT1; HIVE1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Affinity Capture-Western [3]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [5]
7 Affinity Capture-Western [6]
8 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Interacting Protein Info
UniProt ID
CDK9_HUMAN 
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [3]
6 Affinity Capture-Western [4]
7 Affinity Capture-Western [5]
8 Affinity Capture-Western [6]
9 Reconstituted Complex [4]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Protein Name Histone-lysine N-methyltransferase NSD3 (NSD3) Interacting Protein Interacting Protein Info
UniProt ID
NSD3_HUMAN 
Synonyms NSD3; pp14328
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [9]
5 Reconstituted Complex [9]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name Histone arginine demethylase JMJD6 (JMJD6) Interacting Protein Interacting Protein Info
UniProt ID
JMJD6_HUMAN 
Synonyms PSR; PTDSR; PTDSR1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [2]
3 Yeast two hybrid [10]
Other proteins [+] 1 Other proteins +
Interacting Target Name Bromodomain-containing protein 3 (BRD3) Clinical trial Target Interacting Protein Info
UniProt ID
BRD3_HUMAN 
Synonyms RING3-like protein; RING3like protein; RING3L; KIAA0043
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Co-fractionation [11]
References  Top
REF 1 The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell. 2005 Aug 19;19(4):523-34.
REF 2 The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol. 2011 Jul;31(13):2641-52.
REF 3 Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression. Mol Cell Biol. 2008 Feb;28(3):967-76.
REF 4 Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13690-5.
REF 5 Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell. 2005 Aug 19;19(4):535-45.
REF 6 AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E15-24.
REF 7 Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell. 2009 Sep 18;138(6):1122-36.
REF 8 NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. Cancer Discov. 2014 Aug;4(8):928-41.
REF 9 NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Mol Cell. 2015 Dec 17;60(6):847-59.
REF 10 A Y2H-seq approach defines the human protein methyltransferase interactome. Nat Methods. 2013 Apr;10(4):339-42.
REF 11 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.

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