Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | Serine/threonine-protein kinase pim-1 (PIM1) | Clinical trial | Target Info | ||
UniProt ID | PIM1_HUMAN | ||||
Gene Name | PIM1 | ||||
Gene ID | 5292 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [2] | ||
Interacting Clinical trial Target(s) | Microtubule affinity regulating kinase 3 (MARK3) | Target Info | PPI Info | [3] | |
Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [4] | ||
Interacting Literature-reported Target(s) | Proto-oncogene c-Myc (MYC) | Target Info | PPI Info | [5] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 2 | Regulation of Pim-1 by Hsp90. Biochem Biophys Res Commun. 2001 Mar 2;281(3):663-9. | ||||
REF 3 | The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. J Biol Chem. 2004 Nov 12;279(46):48319-28. | ||||
REF 4 | 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF). FEBS Lett. 2009 Feb 18;583(4):615-20. | ||||
REF 5 | A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity. Sci Rep. 2017 Jun 15;7(1):3598. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.