Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | F-box and WD-40 domain protein 7 (Fbxw7) | Literature-reported | Target Info | ||
UniProt ID | FBXW7_HUMAN | ||||
Gene Name | FBXW7 | ||||
Gene ID | 55294 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Nuclear factor NF-kappa-B (NFKB) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) | Target Info | PPI Info | [2] | |
Notch-1 receptor (NOTCH1) | Target Info | PPI Info | [3] | ||
Interacting Discontinued Target(s) | Transcription factor AP-1 (JUN) | Target Info | PPI Info | [4] | |
Interacting Literature-reported Target(s) | Proto-oncogene c-Myc (MYC) | Target Info | PPI Info | [5] | |
G1/S-specific cyclin-E1 (CCNE1) | Target Info | PPI Info | [6] | ||
N-myc proto-oncogene protein (MYCN) | Target Info | PPI Info | [7] |
References | Top | ||||
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REF 1 | Fbxw7- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol. 2012 Mar 4;14(4):375-85. | ||||
REF 2 | Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 May 1;77(9):2512-2521. | ||||
REF 3 | NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Mol Cell. 2012 Nov 9;48(3):445-58. | ||||
REF 4 | The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science. 2004 Feb 27;303(5662):1374-8. | ||||
REF 5 | Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 2004 May 19;23(10):2116-25. | ||||
REF 6 | Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem. 2004 Nov 26;279(48):50110-9. | ||||
REF 7 | Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2009 Jan 6;15(1):67-78. |
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