Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T10052 Target Info
Target Name G1/S-specific cyclin-E1 (CCNE1)
Synonyms G1/S-specific cyclin E; Cyclin E; CCNE
Target Type Literature-reported Target
Gene Name CCNE1
UniProt ID
CCNE1_HUMAN 
Target Interacting Proteins  Top
Cullins [+] 1 Cullins +
Interacting Target Name Cullin-3 (CUL-3) Literature-reported Target Interacting Protein Info
UniProt ID
CUL3_HUMAN 
Synonyms KIAA0617; Cullin3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Yeast two hybrid [1]
Histones [+] 1 Histones +
Interacting Protein Name Histone H1.1 (HIST1H1A) Interacting Protein Interacting Protein Info
UniProt ID
H11_HUMAN 
Synonyms H1.1; H1A; H1F1; HIST1
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [6]
4 Biochemical Activity [7]
5 Biochemical Activity [8]
6 Biochemical Activity [9]
7 Biochemical Activity [10]
8 Biochemical Activity [11]
9 Biochemical Activity [12]
10 Biochemical Activity [13]
11 Biochemical Activity [6]
12 Biochemical Activity [14]
Kinases [+] 2 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [16]
3 Affinity Capture-Western [17]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [18]
6 Affinity Capture-Western [19]
7 Affinity Capture-Western [20]
8 Affinity Capture-Western [21]
9 Affinity Capture-Western [22]
10 Affinity Capture-Western [23]
11 Affinity Capture-Western [24]
12 Affinity Capture-Western [25]
13 Affinity Capture-Western [26]
14 Affinity Capture-Western [27]
15 Affinity Capture-Western [28]
16 Affinity Capture-Western [29]
17 Affinity Capture-Western [30]
18 Affinity Capture-Western [31]
19 Affinity Capture-Western [32]
20 Affinity Capture-Western [33]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [19]
4 Co-purification [15]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Forkhead box protein M1 (FOXM1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXM1_HUMAN 
Synonyms Winged-helix factor from INS-1 cells; Winged helix factor from INS-1 cells; WIN; Transcription factor Trident; MPP2; MPM-2 reactive phosphoprotein 2; M-phase phosphoprotein 2; HNF-3/fork-head homolog-11; HNF-3/fork-head homolog 11; HFH-11; HFH11; Hepatocyte nuclear factor 3 forkhead homolog 11; Foxm1b; Foxm1; Forkhead-related protein FKHL16; Forkhead Box (Fox) m1b; FKHL16
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Biochemical Activity [35]
Other proteins [+] 3 Other proteins +
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Affinity Capture-Western [16]
3 Affinity Capture-Western [17]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [37]
6 Affinity Capture-Western [19]
7 Affinity Capture-Western [21]
8 Affinity Capture-Western [38]
9 Affinity Capture-Western [23]
10 Affinity Capture-Western [24]
11 Affinity Capture-Western [32]
12 Affinity Capture-Western [39]
13 Affinity Capture-Western [40]
14 Affinity Capture-Western [12]
15 Affinity Capture-Western [41]
16 Biochemical Activity [32]
17 Biochemical Activity [13]
18 Co-localization [42]
19 Reconstituted Complex [9]
20 Reconstituted Complex [13]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Affinity Capture-Western [16]
3 Affinity Capture-Western [17]
4 Affinity Capture-Western [10]
5 Affinity Capture-Western [22]
6 Affinity Capture-Western [40]
7 Affinity Capture-Western [12]
8 Affinity Capture-Western [41]
9 Co-localization [42]
10 Reconstituted Complex [37]
11 Yeast two hybrid [44]
Interacting Target Name F-box and WD-40 domain protein 7 (Fbxw7) Literature-reported Target Interacting Protein Info
UniProt ID
FBXW7_HUMAN 
Synonyms SEL-10; SEL10; hCdc4; hAgo; FBX30; FBW7; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; F-box protein Fbxw6; F-box protein FBX30; F-box protein FBW7; F-box and WD-40 domain-containing protein 7; Archipelago homolog
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-peptide [45]
2 Protein-peptide [46]
3 Reconstituted Complex [47]
References  Top
REF 1 Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 1999 Sep 15;13(18):2375-87.
REF 2 The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer. Mol Biol Cell. 2007 Mar;18(3):899-909.
REF 3 The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells. Cell Rep. 2016 Aug 9;16(6):1629-1641.
REF 4 A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation. Oncogene. 2012 Aug 30;31(35):3989-98.
REF 5 Inhibition of cyclin E-cyclin-dependent kinase 2 complex formation and activity is associated with cell cycle arrest and withdrawal in oligodendrocyte progenitor cells. J Neurosci. 2001 Feb 15;21(4):1274-82.
REF 6 Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene. 1998 Nov 19;17(20):2637-43.
REF 7 PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec;2(6):877-85.
REF 8 The cyclin box and C-terminus of cyclins A and E specify CDK activation and substrate specificity. Oncogene. 1997 Jan 30;14(4):491-8.
REF 9 Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest. Mol Cell Biol. 2002 May;22(9):2993-3002.
REF 10 Modulation of cell cycle control by vitamin D3 and its analogue, EB1089, in human breast cancer cells. Oncogene. 1997 Sep 25;15(13):1555-63.
REF 11 Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur J Biochem. 1996 Apr 15;237(2):460-7.
REF 12 Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells. Oncogene. 1998 May;16(20):2575-83.
REF 13 Mechanism of Cdk2/Cyclin E inhibition by p27 and p27 phosphorylation. Biochemistry. 1999 Jul 6;38(27):8713-22.
REF 14 Mad1 expression in the absence of differentiation: effect of cAMP on the B-lymphoid cell line Reh. J Cell Physiol. 1999 Jan;178(1):76-84.
REF 15 Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science. 1992 Sep 18;257(5077):1689-94.
REF 16 Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell. 1998 Mar;1(4):553-63.
REF 17 Differential modulation of G1-S-phase cyclin-dependent kinase 2/cyclin complexes occurs during the acquisition of a polyploid DNA content. Cell Growth Differ. 1998 Aug;9(8):639-50.
REF 18 Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem. 1996 May 31;271(22):13283-91.
REF 19 Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. Mol Cell Biol. 1999 Feb;19(2):1460-9.
REF 20 Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7211-6.
REF 21 Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 1996 Dec 2;15(23):6595-604.
REF 22 P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest. Cancer Res. 2003 Jul 1;63(13):3840-4.
REF 23 CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell. 2003 Jan;14(1):201-13.
REF 24 Cyclin D1 regulates p27(Kip1) stability in B cells. Cell Signal. 2011 Jan;23(1):171-9.
REF 25 The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J Biol Chem. 2006 Jan 6;281(1):241-51.
REF 26 Peptide-mediated disruption of calmodulin-cyclin E interactions inhibits proliferation of vascular smooth muscle cells and neointima formation. Circ Res. 2011 Apr 29;108(9):1053-62.
REF 27 Sodium butyrate regulates androgen receptor expression and cell cycle arrest in human prostate cancer cells. Anticancer Res. 2007 Sep-Oct;27(5A):3285-92.
REF 28 Autocatalytic phosphorylation of CDK2 at the activating Thr160. Cell Cycle. 2007 Apr 1;6(7):843-52.
REF 29 A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science. 2004 Oct 29;306(5697):885-8.
REF 30 Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. J Biol Chem. 2004 Mar 26;279(13):12695-705.
REF 31 CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. Eur J Cell Biol. 2003 May;82(5):253-61.
REF 32 Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 1997 Jun 1;11(11):1464-78.
REF 33 Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J Cell Biol. 2008 Jun 16;181(6):913-20.
REF 34 Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators. Mol Cell Biol. 2004 Apr;24(7):2649-61.
REF 35 Regulation of the transcription factor FOXM1c by Cyclin E/CDK2. FEBS Lett. 2006 Mar 20;580(7):1716-22.
REF 36 p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell. 2007 Jan 26;128(2):281-94.
REF 37 Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996 Sep;16(9):4673-82.
REF 38 Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell. 2007 Jan 26;128(2):269-80.
REF 39 RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9268-73.
REF 40 Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. J Biol Chem. 2007 May 18;282(20):14882-90.
REF 41 The CDK inhibitor, p27Kip1, is required for IL-4 regulation of astrocyte proliferation. J Immunol. 1997 Jul 15;159(2):812-9.
REF 42 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 43 UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Cell. 2003 Sep 5;114(5):599-610.
REF 44 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 45 Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem. 2004 Nov 26;279(48):50110-9.
REF 46 The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science. 2004 Feb 27;303(5662):1374-8.
REF 47 Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature. 2001 Sep 20;413(6853):316-22.

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