Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T69085 Target Info
Target Name Transcription factor AP-1 (JUN)
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Proto-oncogene c-jun; P39; C-jun proto-oncogene; Activator protein-1; Activator protein 1; AP1; AP-1 transcription factor
Target Type Discontinued Target
Gene Name JUN
Biochemical Class Basic leucine zipper bZIP
UniProt ID
JUN_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Co-crystal Structure [3]
4 Co-fractionation [3]
5 Co-localization [4]
6 Reconstituted Complex [5]
Interacting Protein Name Cyclic AMP-dependent transcription factor ATF-2 (ATF2) Interacting Protein Interacting Protein Info
UniProt ID
ATF2_HUMAN 
Synonyms CRE.BP1; CREB.2; CREB2; HB16; TREB7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
3 Co-localization [8]
4 Fluorescence Resonance Energy Transfer [9]
5 Reconstituted Complex [10]
Interacting Target Name E3 ubiquitin-protein ligase COP1 (RFWD2) Literature-reported Target Interacting Protein Info
UniProt ID
COP1_HUMAN 
Synonyms RNF200; RING-type E3 ubiquitin transferase RFWD2; RING finger protein 200; RING finger and WD repeat domain protein 2; hCOP1; E3 ubiquitinprotein ligase RFWD2; COP1; Constitutive photomorphogenesis protein 1 homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Interacting Protein Info
UniProt ID
SIR1_HUMAN 
Synonyms SIR2-like protein 1; SIR2L1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; hSIR2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [14]
3 Biochemical Activity [15]
4 Reconstituted Complex [15]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [17]
3 Yeast two hybrid [16]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [10]
2 Yeast two hybrid [18]
Isomerases [+] 1 Isomerases +
Interacting Target Name Rotamase Pin1 (PIN1) Clinical trial Target Interacting Protein Info
UniProt ID
PIN1_HUMAN 
Synonyms Prolyl isomerase Pin1; PPIase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Reconstituted Complex [20]
Kinases [+] 6 Kinases +
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Biochemical Activity [22]
3 Reconstituted Complex [23]
4 Yeast two hybrid [24]
Interacting Target Name Stress-activated protein kinase JNK2 (JNK2) Preclinical Target Interacting Protein Info
UniProt ID
MK09_HUMAN 
Synonyms Stress-activated protein kinase 1a; SAPK1a; PRKM9; Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 8-interacting protein 2; MAPK 9; MAP kinase 9; Jun-N-terminal kinase 2; JNK-interacting protein 2; JNK-55; JNK MAP kinase scaffold protein 2; JIP-2; Islet-brain-2; IB-2; C-jun-amino-terminal kinase interacting protein 2; C-Jun N-terminal kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [25]
2 Reconstituted Complex [26]
3 Yeast two hybrid [24]
Interacting Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Interacting Protein Info
UniProt ID
GSK3B_HUMAN 
Synonyms Serine/threonine-protein kinase GSK3B; GSK-3 beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [27]
2 Co-localization [28]
Interacting Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target Interacting Protein Info
UniProt ID
MK01_HUMAN 
Synonyms PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [20]
2 Reconstituted Complex [29]
Interacting Target Name MAPK/ERK kinase kinase 1 (MAP3K1) Clinical trial Target Interacting Protein Info
UniProt ID
M3K1_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 1; Mitogenactivated protein kinase kinase kinase 1; MEKK1; MEKK 1; MEKK; MEK kinase 1; MAPKKK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [31]
Interacting Target Name Stress-activated protein kinase JNK3 (JNK3) Patented-recorded Target Interacting Protein Info
UniProt ID
MK10_HUMAN 
Synonyms Stress-activated protein kinase 1b; SAPK1b; PRKM10; Mitogen-activated protein kinase 10; MAPK 10; MAP kinase p49 3F12; MAP kinase 10; JNK3A; C-Jun N-terminal kinase 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [32]
2 Reconstituted Complex [26]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Reconstituted Complex [34]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Co-localization [35]
3 Reconstituted Complex [36]
4 Yeast two hybrid [35]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Protein Name Amyloid-like protein 2 (APLP2) Interacting Protein Interacting Protein Info
UniProt ID
APLP2_HUMAN 
Synonyms APLP.2; APPH; APPL2; CDEBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [10]
2 Yeast two hybrid [18]
Transcription regulators [+] 14 Transcription regulators +
Interacting Target Name Proto-oncogene c-Fos (c-Fos) Literature-reported Target Interacting Protein Info
UniProt ID
FOS_HUMAN 
Synonyms Proto-oncogene c-Fos; G0S7; G0/G1 switch regulatory protein 7; C-fos; Cellular oncogene fos
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [37]
2 Affinity Capture-Western [38]
3 Co-crystal Structure [39]
4 Co-fractionation [40]
5 Co-localization [41]
6 Fluorescence Resonance Energy Transfer [9]
7 Protein-Fragment Complementation Assay [42]
8 Reconstituted Complex [43]
9 Yeast two hybrid [44]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Co-localization [46]
3 Far Western [47]
4 Reconstituted Complex [5]
Interacting Target Name Activating transcription factor 4 (ATF-4) Literature-reported Target Interacting Protein Info
UniProt ID
ATF4_HUMAN 
Synonyms TXREB; Tax-responsive enhancer element-binding protein 67; Taxresponsive enhancer elementbinding protein 67; TaxREB67; DNA-binding protein TAXREB67; DNAbinding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMPdependent transcription factor ATF4; CREB-2; CREB2; cAMP-responsive element-binding protein 2; cAMPresponsive elementbinding protein 2; cAMP-dependent transcription factor ATF-4; cAMPdependent transcription factor ATF4
Evidence Score (E-score) 4 Experimental Evidences +
1 Co-localization [28]
2 Fluorescence Resonance Energy Transfer [9]
3 Reconstituted Complex [48]
4 Yeast two hybrid [18]
Interacting Target Name Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) Literature-reported Target Interacting Protein Info
UniProt ID
ATF3_HUMAN 
Synonyms Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [49]
3 Fluorescence Resonance Energy Transfer [9]
4 Reconstituted Complex [48]
Interacting Target Name Fos-related antigen 1 (FOSL1) Literature-reported Target Interacting Protein Info
UniProt ID
FOSL1_HUMAN 
Synonyms Fra-1; FRA1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [38]
2 Fluorescence Resonance Energy Transfer [9]
3 Reconstituted Complex [43]
4 Yeast two hybrid [43]
Interacting Target Name Runt-related transcription factor 2 (RUNX2) Literature-reported Target Interacting Protein Info
UniProt ID
RUNX2_HUMAN 
Synonyms SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha Asubunit; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2-alpha A; PEBP2A; PEA2-alpha A; Osteoblast-specific transcription factor 2; OSF-2; OSF2; Oncogene AML-3; Core-binding factor subunit alpha-1; CBF-alpha-1; CBFA1; AML3; Acute myeloid leukemia 3 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Reconstituted Complex [50]
3 Yeast two hybrid [51]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Reconstituted Complex [52]
3 Yeast two hybrid [52]
Interacting Target Name Nuclear factor erythroid 2-related factor 2 (Nrf2) Successful Target Interacting Protein Info
UniProt ID
NF2L2_HUMAN 
Synonyms Nuclear factor, erythroid derived 2, like 2; NRF2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Reconstituted Complex [53]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Reconstituted Complex [55]
Interacting Target Name Cyclic AMP-responsive element-binding protein (CREB1) Literature-reported Target Interacting Protein Info
UniProt ID
CREB1_HUMAN 
Synonyms Cyclic AMP-responsive element-binding protein 1; Cyclic AMP responseelement-binding protein; CREB-1; CREB; cAMP-responsive element-binding protein 1; CAMP-response element binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [56]
Interacting Target Name Fos-related antigen 2 (FOSL2) Literature-reported Target Interacting Protein Info
UniProt ID
FOSL2_HUMAN 
Synonyms FRA-2; FRA2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [37]
2 Yeast two hybrid [43]
Interacting Protein Name Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) Interacting Protein Interacting Protein Info
UniProt ID
BATF3_HUMAN 
Synonyms JDP1; JUNDM1; SNFT
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Fluorescence Resonance Energy Transfer [9]
Interacting Protein Name Protein fosB (FOSB) Interacting Protein Interacting Protein Info
UniProt ID
FOSB_HUMAN 
Synonyms AP.1; G0S3; GOS3; GOSB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Protein-Fragment Complementation Assay [57]
Interacting Protein Name Nuclear factor of activated T cells 2 (NFATC2) Interacting Protein Interacting Protein Info
UniProt ID
NFAC2_HUMAN 
Synonyms NFAT1; NFATP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Reconstituted Complex [58]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [59]
2 Yeast two hybrid [18]
Other proteins [+] 3 Other proteins +
Interacting Target Name F-box and WD-40 domain protein 7 (Fbxw7) Literature-reported Target Interacting Protein Info
UniProt ID
FBXW7_HUMAN 
Synonyms SEL-10; SEL10; hCdc4; hAgo; FBX30; FBW7; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; F-box protein Fbxw6; F-box protein FBX30; F-box protein FBW7; F-box and WD-40 domain-containing protein 7; Archipelago homolog
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-peptide [60]
2 Reconstituted Complex [20]
3 Yeast two hybrid [60]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [61]
2 Co-localization [62]
3 Reconstituted Complex [63]
Interacting Protein Name Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) Interacting Protein Interacting Protein Info
UniProt ID
GOPC_HUMAN 
Synonyms CAL; FIG; GOPC1; PIST; dJ94G16.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Reconstituted Complex [10]
References  Top
REF 1 Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells. J Cell Biochem. 2011 Feb;112(2):589-99.
REF 2 Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription. J Biol Chem. 2011 Nov 25;286(47):40974-86.
REF 3 Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB. Biochemistry. 2002 Nov 26;41(47):13956-64.
REF 4 Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood. 2004 Mar 15;103(6):2135-42.
REF 5 The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A. Oncogene. 1999 Apr 8;18(14):2311-21.
REF 6 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 7 Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene. J Leukoc Biol. 1994 Jul;56(1):27-35.
REF 8 Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol Cell. 2004 Nov 19;16(4):521-35.
REF 9 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4.
REF 10 A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One. 2010 Feb 24;5(2):e9289.
REF 11 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 12 Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity. J Biol Chem. 2003 May 30;278(22):19682-90.
REF 13 A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol. 2013 Apr;33(8):1487-502.
REF 14 Inhibition of transcriptional activity of c-JUN by SIRT1. Biochem Biophys Res Commun. 2008 Nov 28;376(4):793-6.
REF 15 SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem. 2010 Mar 5;285(10):7097-110.
REF 16 Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site. J Biol Chem. 1999 Feb 26;274(9):5454-61.
REF 17 Rb binds c-Jun and activates transcription. EMBO J. 1998 Apr 15;17(8):2342-52.
REF 18 A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
REF 19 Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 2001 Jul 2;20(13):3459-72.
REF 20 Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase. Structure. 2018 Jan 2;26(1):28-39.e2.
REF 21 Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway. Mol Cell Biol. 1997 Mar;17(3):1170-9.
REF 22 Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. J Biol Chem. 2004 Mar 5;279(10):9023-9.
REF 23 Regulation of two JunD isoforms by Jun N-terminal kinases. J Biol Chem. 2002 Aug 16;277(33):29710-8.
REF 24 Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation. Cancer Res. 2007 Sep 15;67(18):8725-35.
REF 25 c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 1996 Nov 29;87(5):929-39.
REF 26 Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996 Jun 3;15(11):2760-70.
REF 27 PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells. Mol Biol Cell. 2007 Mar;18(3):1118-27.
REF 28 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 29 Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm. J Biol Chem. 1999 Jul 30;274(31):21900-7.
REF 30 CSN6 positively regulates c-Jun in a MEKK1-dependent manner. Cell Cycle. 2015;14(19):3079-87.
REF 31 1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2. J Biol Chem. 2003 Aug 15;278(33):30711-8.
REF 32 Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science. 1998 May 22;280(5367):1262-5.
REF 33 Estrogen receptor alpha and the activating protein-1 complex cooperate during insulin-like growth factor-I-induced transcriptional activation of the pS2/TFF1 gene. J Biol Chem. 2007 Apr 20;282(16):11732-41.
REF 34 Characterization of the physical interaction between estrogen receptor alpha and JUN proteins. J Biol Chem. 2001 Sep 28;276(39):36361-9.
REF 35 A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature. 1996 Oct 3;383(6599):453-7.
REF 36 Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature. 2000 Apr 6;404(6778):617-21.
REF 37 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 38 Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA. J Biol Chem. 2001 Aug 24;276(34):32362-72.
REF 39 Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature. 1995 Jan 19;373(6511):257-61.
REF 40 c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics. Mol Cell Biol. 2010 Aug;30(15):3767-78.
REF 41 Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72(16):4214-24.
REF 42 Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation. Biochem J. 2011 Sep 15;438(3):495-503.
REF 43 Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. Oncogene. 1997 May 1;14(17):2091-8.
REF 44 ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB. J Biol Chem. 1999 Sep 24;274(39):27981-8.
REF 45 CBP alleviates the intramolecular inhibition of ATF-2 function. J Biol Chem. 1998 Oct 30;273(44):29098-105.
REF 46 Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2. J Biol Chem. 2005 Sep 23;280(38):32569-77.
REF 47 Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 1994 Jul 21;370(6486):226-9.
REF 48 Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3720-4.
REF 49 ATF3 enhances c-Jun-mediated neurite sprouting. Brain Res Mol Brain Res. 2003 Dec 12;120(1):38-45.
REF 50 AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem. 2001 Jun 8;276(23):20029-38.
REF 51 Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem. 2002 Jan 4;277(1):816-22.
REF 52 Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 1998 Aug 27;394(6696):909-13.
REF 53 Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene. 1998 Dec 17;17(24):3145-56.
REF 54 Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. Mol Cell Biol. 2006 Mar;26(5):1770-85.
REF 55 c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1. J Biol Chem. 1999 Oct 8;274(41):29572-81.
REF 56 Heterodimer formation between CREB and JUN proteins. Oncogene. 1990 Mar;5(3):295-302.
REF 57 Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis. Cell Rep. 2017 Oct 10;21(2):442-454.
REF 58 The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription. Mol Immunol. 2010 Aug;47(14):2314-22.
REF 59 Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14782-7.
REF 60 The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science. 2004 Feb 27;303(5662):1374-8.
REF 61 The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage. Blood. 2005 May 1;105(9):3686-90.
REF 62 Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies. Genes Cells. 1999 Dec;4(12):743-56.
REF 63 Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling. Mol Cell. 2006 Aug;23(4):547-59.

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