Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | MAPK/ERK kinase kinase 1 (MAP3K1) | Clinical trial | Target Info | ||
UniProt ID | M3K1_HUMAN | ||||
Gene Name | MAP3K1 | ||||
Gene ID | 4214 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Clinical trial Target(s) | Extracellular signal-regulated kinase 2 (ERK2) | Target Info | PPI Info | [1] | |
Stress-activated protein kinase JNK1 (JNK1) | Target Info | PPI Info | [2] | ||
Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [3] | ||
MAPK/ERK kinase kinase 1 (MAP3K1) | Target Info | PPI Info | [4] | ||
Interacting Patented-recorded Target(s) | MEK kinase kinase 2 (MAP4K2) | Target Info | PPI Info | [4] | |
Interacting Discontinued Target(s) | Transcription factor AP-1 (JUN) | Target Info | PPI Info | [5] | |
Transforming protein RhoA (RHOA) | Target Info | PPI Info | [6] | ||
Interacting Literature-reported Target(s) | Beta-arrestin-2 (ARRB2) | Target Info | PPI Info | [7] |
References | Top | ||||
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REF 1 | MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem. 2000 Dec 22;275(51):40120-7. | ||||
REF 2 | MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J Biol Chem. 1997 Dec 19;272(51):32056-60. | ||||
REF 3 | MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein. J Biol Chem. 2010 Dec 10;285(50):38818-31. | ||||
REF 4 | Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol Cell Biol. 2002 Feb;22(3):737-49. | ||||
REF 5 | CSN6 positively regulates c-Jun in a MEKK1-dependent manner. Cell Cycle. 2015;14(19):3079-87. | ||||
REF 6 | RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. J Biol Chem. 2004 Jan 16;279(3):1872-7. | ||||
REF 7 | Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6. |
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