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Target General Information |
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Target ID |
T07191 |
Target Info
|
Target Name |
MEK kinase kinase 2 (MAP4K2) |
Synonyms |
Rab8-interacting protein; RAB8IP; Mitogen-activated protein kinase kinase kinase kinase 2; MEKKK 2; MAPK/ERK kinase kinase kinase 2; Germinal center kinase; GCK; GC kinase; B lymphocyte serine/threonine-protein kinase |
Target Type |
Patented-recorded Target |
Gene Name |
MAP4K2 |
Biochemical Class |
Kinase |
UniProt ID |
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Target Interacting Proteins |
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Kinases |
[+] 1 Kinases |
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Interacting Target Name |
MAPK/ERK kinase kinase 1 (MAP3K1) |
Clinical trial Target |
Interacting Protein Info
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UniProt ID |
|
Synonyms |
Mitogen-activated protein kinase kinase kinase 1; Mitogenactivated protein kinase kinase kinase 1; MEKK1; MEKK 1; MEKK; MEK kinase 1; MAPKKK1 |
Evidence Score (E-score) |
2 Experimental Evidences |
+ |
1 |
Affinity Capture-Western |
[1] |
2 |
Reconstituted Complex |
[2] |
References |
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REF 1 |
Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol Cell Biol. 2002 Feb;22(3):737-49.
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REF 2 |
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J Biol Chem. 1998 Aug 28;273(35):22681-92.
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