Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T16243 Target Info
Target Name Beta-arrestin-2 (ARRB2)
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta2; Arrestin beta-2; ARR2; ARB2
Target Type Literature-reported Target
Gene Name ARRB2
Biochemical Class Arrestin protein
UniProt ID
ARRB2_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Filamin A (FLNA) Clinical trial Target Interacting Protein Info
UniProt ID
FLNA_HUMAN 
Synonyms Non-muscle filamin; Nonmuscle filamin; FLN-A; FLN1; FLN; Filamin-A; Filamin-1; Filamin 1; Endothelial actin-binding protein; Endothelial actin cytoskeleton; Alpha-filamin; Actin-binding protein 280; ABP-280
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Protein phosphatase 1B (PPM1B) Interacting Protein Interacting Protein Info
UniProt ID
PPM1B_HUMAN 
Synonyms PP2C.beta; PP2C.beta.X; PP2CB; PP2CBETA; PPC2BETAX
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Co-localization [3]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Adrenergic receptor beta-2 (ADRB2) Successful Target Interacting Protein Info
UniProt ID
ADRB2_HUMAN 
Synonyms Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Fluorescence Resonance Energy Transfer [5]
Kinases [+] 7 Kinases +
Interacting Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target Interacting Protein Info
UniProt ID
MK01_HUMAN 
Synonyms PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Co-localization [3]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [8]
2 Yeast two hybrid [9]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [11]
Interacting Target Name MAPK/ERK kinase kinase 1 (MAP3K1) Clinical trial Target Interacting Protein Info
UniProt ID
M3K1_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 1; Mitogenactivated protein kinase kinase kinase 1; MEKK1; MEKK 1; MEKK; MEK kinase 1; MAPKKK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-localization [3]
Interacting Target Name Stress-activated protein kinase JNK3 (JNK3) Patented-recorded Target Interacting Protein Info
UniProt ID
MK10_HUMAN 
Synonyms Stress-activated protein kinase 1b; SAPK1b; PRKM10; Mitogen-activated protein kinase 10; MAPK 10; MAP kinase p49 3F12; MAP kinase 10; JNK3A; C-Jun N-terminal kinase 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Protein-peptide [13]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-localization [3]
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) Interacting Protein Interacting Protein Info
UniProt ID
MP2K4_HUMAN 
Synonyms JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK.1; SAPKK1; SEK1; SERK1; SKK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Protein-peptide [13]
Peptidases [+] 1 Peptidases +
Interacting Target Name VHL-interacting deubiquitinating enzyme 1 (VDU1) Patented-recorded Target Interacting Protein Info
UniProt ID
UBP33_HUMAN 
Synonyms Ubiquitin-specific-processing protease 33; Ubiquitin thioesterase 33; Ubiquitin carboxyl-terminal hydrolase 33; KIAA1097; hVDU1; Deubiquitinating enzyme 33
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [16]
3 Affinity Capture-Western [17]
4 Reconstituted Complex [17]
5 Yeast two hybrid [17]
Putative transporters [+] 2 Putative transporters +
Interacting Protein Name AP-2 complex subunit beta (AP2B1) Interacting Protein Interacting Protein Info
UniProt ID
AP2B1_HUMAN 
Synonyms ADTB2; AP105B; AP2.BETA; CLAPB1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [18]
3 Yeast two hybrid [19]
Interacting Protein Name AP-3 complex subunit beta-2 (AP3B2) Interacting Protein Interacting Protein Info
UniProt ID
AP3B2_HUMAN 
Synonyms NAPTB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [20]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [22]
4 Affinity Capture-Western [23]
5 Affinity Capture-Western [24]
6 Affinity Capture-Western [25]
7 Affinity Capture-Western [26]
8 Fluorescence Resonance Energy Transfer [2]
9 Yeast two hybrid [27]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Fluorescence Resonance Energy Transfer [28]
Other proteins [+] 5 Other proteins +
Interacting Protein Name Nucleolar and coiled-body phosphoprotein 1 (NOLC1) Interacting Protein Interacting Protein Info
UniProt ID
NOLC1_HUMAN 
Synonyms NOPP130; NOPP140; NS5ATP13; P130
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [29]
3 Affinity Capture-MS [30]
4 Affinity Capture-Western [1]
Interacting Protein Name NF-kappa-B inhibitor alpha (NFKBIA) Interacting Protein Interacting Protein Info
UniProt ID
IKBA_HUMAN 
Synonyms IKBA; MAD.3; NFKBI
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Affinity Capture-Western [32]
3 Reconstituted Complex [32]
Interacting Protein Name Treacle protein (TCOF1) Interacting Protein Interacting Protein Info
UniProt ID
TCOF_HUMAN 
Synonyms MFD1; TCS; TCS1; treacle
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [30]
3 Affinity Capture-Western [1]
Interacting Protein Name Catenin alpha-1 (CTNNA1) Interacting Protein Interacting Protein Info
UniProt ID
CTNA1_HUMAN 
Synonyms CAP102
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-localization [3]
Interacting Protein Name Src substrate cortactin (CTTN) Interacting Protein Interacting Protein Info
UniProt ID
SRC8_HUMAN 
Synonyms EMS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-localization [3]
References  Top
REF 1 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6.
REF 2 beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18061-6.
REF 3 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 4 CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human adrenergic receptor. Biochem Biophys Res Commun. 2014 Mar 21;445(4):746-56.
REF 5 The -Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the 2-Adrenergic Receptor. J Biol Chem. 2016 Jul 8;291(28):14510-25.
REF 6 Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem. 2005 Apr 15;280(15):15315-24.
REF 7 Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2449-54.
REF 8 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 9 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 10 c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. PLoS One. 2009;4(3):e4686.
REF 11 A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell. 2008 Jan 11;132(1):125-36.
REF 12 Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. J Biol Chem. 2001 Jul 27;276(30):27770-7.
REF 13 A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. FEBS Lett. 2009 Oct 20;583(20):3310-6.
REF 14 Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000 Nov 24;290(5496):1574-7.
REF 15 The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. EMBO J. 2009 Jun 17;28(12):1684-96.
REF 16 Deubiquitinases and their emerging roles in -arrestin-mediated signaling. Methods Enzymol. 2014;535:351-70.
REF 17 Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6650-5.
REF 18 Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking. J Biol Chem. 2011 Feb 4;286(5):3884-93.
REF 19 The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3712-7.
REF 20 Regulation of arrestin-3 phosphorylation by casein kinase II. J Biol Chem. 2002 May 10;277(19):16837-46.
REF 21 Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem. 2003 Feb 21;278(8):6363-70.
REF 22 Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem. 2008 Aug 8;283(32):22166-76.
REF 23 Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination. Biochemistry. 2011 May 10;50(18):3749-63.
REF 24 Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of -arrestin2. Mol Biol Cell. 2011 May;22(9):1608-16.
REF 25 {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem. 2005 Jul 1;280(26):24412-9.
REF 26 Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2. J Biol Chem. 2011 Jan 14;286(2):1165-73.
REF 27 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 28 Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes. J Biol Chem. 2011 May 13;286(19):16726-33.
REF 29 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 30 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 31 beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8603-7.
REF 32 Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol Cell. 2004 May 7;14(3):303-17.

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