Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) | ||||
| UniProt ID | MP2K4_HUMAN | ||||
| Gene Name | MAP2K4 | ||||
| Gene ID | 6416 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Apoptosis signal-regulating kinase 1 (MAP3K5) | Target Info | PPI Info | [2] | |
| MAPK/ERK kinase kinase 1 (MAP3K1) | Target Info | PPI Info | [3] | ||
| MAPK/ERK kinase kinase 2 (MAP3K2) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | Beta-arrestin-2 (ARRB2) | Target Info | PPI Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. J Biol Chem. 2002 Jan 25;277(4):2573-8. | ||||
| REF 2 | Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5. Cell Death Differ. 2007 Aug;14(8):1518-28. | ||||
| REF 3 | Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr;20(7):2334-42. | ||||
| REF 4 | Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000 Nov 24;290(5496):1574-7. | ||||
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