Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T76508 Target Info
Target Name MAPK/ERK kinase kinase 2 (MAP3K2)
Synonyms Mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK 2; MEK kinase 2; MAPKKK2
Target Type Clinical trial Target
Gene Name MAP3K2
Biochemical Class Kinase
UniProt ID
M3K2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Kinases [+] 4 Kinases +
Interacting Target Name ERK activator kinase 5 (MAP2K5) Literature-reported Target Interacting Protein Info
UniProt ID
MP2K5_HUMAN 
Synonyms PRKMK5; MKK5; Mitogen-activatedprotein kinase kinase 5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase5; MAP kinase kinase 5; Dual specificity mitogen-activated protein kinase kinase 5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [2]
3 Reconstituted Complex [2]
4 Yeast two hybrid [4]
Interacting Target Name ERK activator kinase 7 (MAP2K7) Literature-reported Target Interacting Protein Info
UniProt ID
MP2K7_HUMAN 
Synonyms Stress-activated protein kinase kinase 4; SKK4; SAPKK-4; SAPKK4; SAPK kinase 4; PRKMK7; MKK7; Mitogen-activated protein kinase kinase 7; MEK7; MEK 7; MAPKK 7; MAPK/ERK kinase7; MAPK/ERK kinase 7; MAP kinase kinase 7; JNKK2; JNKK 2; JNK-activating kinase 2; JNK kinase 2; JNK activating kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; C-Jun N-terminal kinase kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [2]
3 Co-fractionation [5]
Interacting Target Name MAPK/ERK kinase kinase 3 (MAP3K3) Literature-reported Target Interacting Protein Info
UniProt ID
M3K3_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 3; MEKK3; MEKK 3; MEK kinase 3; MAPKKK3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Reconstituted Complex [2]
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) Interacting Protein Interacting Protein Info
UniProt ID
MP2K4_HUMAN 
Synonyms JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK.1; SAPKK1; SEK1; SERK1; SKK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [7]
References  Top
REF 1 XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. Cell Signal. 2008 Nov;20(11):2107-12.
REF 2 Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801.
REF 3 PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem. 2010 Jan 15;285(3):2077-89.
REF 4 MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. J Biol Chem. 2001 Feb 16;276(7):5093-100.
REF 5 Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr;20(7):2334-42.
REF 6 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 7 Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). Oncogene. 2008 Mar 20;27(13):1930-8.

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