Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | MAPK/ERK kinase kinase 3 (MAP3K3) | Literature-reported | Target Info | ||
| UniProt ID | M3K3_HUMAN | ||||
| Gene Name | MAP3K3 | ||||
| Gene ID | 4215 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | MAPK/ERK kinase kinase 2 (MAP3K2) | Target Info | PPI Info | [2] | |
| Interacting Literature-reported Target(s) | ERK activator kinase 5 (MAP2K5) | Target Info | PPI Info | [3] | |
| TGF-beta-activated kinase 1 (MAP3K7) | Target Info | PPI Info | [4] | ||
| Sequestosome-1 p62 (SQSTM1) | Target Info | PPI Info | [5] | ||
| TNF receptor-associated factor 6 (TRAF6) | Target Info | PPI Info | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
| REF 2 | Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801. | ||||
| REF 3 | MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. J Biol Chem. 2001 Feb 16;276(7):5093-100. | ||||
| REF 4 | Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. Sci Signal. 2009 Oct 20;2(93):ra66. | ||||
| REF 5 | PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem. 2010 Jan 15;285(3):2077-89. | ||||
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