Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T17367 Target Info
Target Name Sequestosome-1 p62 (SQSTM1)
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Target Type Literature-reported Target
Gene Name SQSTM1
Biochemical Class Zinc-finger
UniProt ID
SQSTM_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Acyltransferases [+] 4 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase parkin (PRKN) Interacting Protein Interacting Protein Info
UniProt ID
PRKN_HUMAN 
Synonyms AR.JP; LPRS2; PDJ; PRKN
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Co-localization [5]
Interacting Protein Name E3 ubiquitin-protein ligase TRIM21 (TRIM21) Interacting Protein Interacting Protein Info
UniProt ID
RO52_HUMAN 
Synonyms RNF81; RO52; Ro/SSA; SSA; SSA1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [8]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Co-localization [10]
Interacting Protein Name Trifunctional enzyme subunit alpha (HADHA) Interacting Protein Interacting Protein Info
UniProt ID
ECHA_HUMAN 
Synonyms ECHA; GBP; HADH; LCEH; LCHAD; MTPA; TP.ALPHA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [6]
Cullins [+] 1 Cullins +
Interacting Target Name Cullin-3 (CUL-3) Literature-reported Target Interacting Protein Info
UniProt ID
CUL3_HUMAN 
Synonyms KIAA0617; Cullin3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Co-localization [13]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Target Name cAMP-dependent chloride channel (CFTR) Successful Target Interacting Protein Info
UniProt ID
CFTR_HUMAN 
Synonyms Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; cAMP-dependent chloride channel; cAMPdependent chloride channel; ATP-binding cassette sub-family C member 7; ATPbinding cassette subfamily C member 7; ABCC7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Co-fractionation [14]
3 Co-localization [15]
Kinases [+] 8 Kinases +
Interacting Target Name Protein kinase C iota (PRKCI) Literature-reported Target Interacting Protein Info
UniProt ID
KPCI_HUMAN 
Synonyms Protein kinase C iota type; PRKC-lambda/iota; nPKC-iota; DXS1179E; Atypical protein kinase C-lambda/iota; aPKC-lambda/iota
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [16]
4 Affinity Capture-Western [17]
5 Affinity Capture-Western [18]
6 Affinity Capture-Western [19]
7 Affinity Capture-Western [20]
8 Co-fractionation [16]
9 Co-localization [20]
10 Fluorescence Resonance Energy Transfer [19]
11 Reconstituted Complex [16]
12 Reconstituted Complex [17]
13 Reconstituted Complex [21]
Interacting Target Name Protein kinase C zeta (PRKCZ) Patented-recorded Target Interacting Protein Info
UniProt ID
KPCZ_HUMAN 
Synonyms Protein kinase C zeta type; PKC2; NPKC-zeta
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [22]
3 Affinity Capture-Western [23]
4 Affinity Capture-Western [24]
5 Affinity Capture-Western [25]
6 Co-localization [26]
7 Protein-peptide [19]
8 Reconstituted Complex [27]
Interacting Target Name ERK activator kinase 5 (MAP2K5) Literature-reported Target Interacting Protein Info
UniProt ID
MP2K5_HUMAN 
Synonyms PRKMK5; MKK5; Mitogen-activatedprotein kinase kinase 5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase5; MAP kinase kinase 5; Dual specificity mitogen-activated protein kinase kinase 5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [17]
3 Reconstituted Complex [10]
4 Reconstituted Complex [17]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Biochemical Activity [22]
3 Reconstituted Complex [22]
Interacting Target Name MAPK/ERK kinase kinase 3 (MAP3K3) Literature-reported Target Interacting Protein Info
UniProt ID
M3K3_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 3; MEKK3; MEKK 3; MEK kinase 3; MAPKKK3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [28]
3 Reconstituted Complex [10]
Interacting Target Name PI3-kinase alpha (PIK3CA) Successful Target Interacting Protein Info
UniProt ID
PK3CA_HUMAN 
Synonyms Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; PtdIns3kinase subunit p110alpha; PtdIns-3-kinase subunit alpha; PtdIns3kinase subunit alpha; PI3-kinase subunit alpha; PI3kinase subunit alpha; PI3K-alpha; PI3Kalpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; p110alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Yeast two hybrid [30]
Interacting Target Name Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target Interacting Protein Info
UniProt ID
MK14_HUMAN 
Synonyms SAPK2A; P38 Mitogen-activatedprotein kinase alpha; P38 mitogen activatedprotein kinase; MXI2; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Reconstituted Complex [32]
Interacting Target Name Serine/threonine-protein kinase ULK1 (ULK1) Literature-reported Target Interacting Protein Info
UniProt ID
ULK1_HUMAN 
Synonyms Unc-51-like kinase 1; KIAA0722; hATG1; Autophagy-related protein 1 homolog; ATG1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Biochemical Activity [34]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Protein Name NOP2/Sun RNA methyltransferase 4 (NSUN4) Interacting Protein Interacting Protein Info
UniProt ID
NSUN4_HUMAN 
Synonyms SHTAP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [6]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Reconstituted Complex [36]
Ubiquitin related proteins [+] 5 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [37]
3 Affinity Capture-Western [38]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [39]
6 Affinity Capture-Western [40]
7 Affinity Capture-Western [41]
8 Affinity Capture-Western [42]
9 Affinity Capture-Western [43]
10 Affinity Capture-Western [44]
11 Co-crystal Structure [33]
12 Co-localization [44]
13 Co-localization [45]
14 Co-localization [46]
15 Co-localization [41]
16 Co-localization [47]
17 Reconstituted Complex [48]
18 Reconstituted Complex [38]
19 Reconstituted Complex [49]
20 Reconstituted Complex [50]
Interacting Protein Name Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) Interacting Protein Interacting Protein Info
UniProt ID
MLP3A_HUMAN 
Synonyms ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3
Evidence Score (E-score) 16 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Affinity Capture-Western [52]
3 Affinity Capture-Western [53]
4 Affinity Capture-Western [54]
5 Affinity Capture-Western [49]
6 Affinity Capture-Western [55]
7 Affinity Capture-Western [56]
8 Affinity Capture-Western [39]
9 Affinity Capture-Western [57]
10 Co-crystal Structure [58]
11 Co-localization [59]
12 Co-localization [57]
13 Co-localization [60]
14 Co-localization [46]
15 Reconstituted Complex [58]
16 Reconstituted Complex [61]
Interacting Protein Name Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) Interacting Protein Interacting Protein Info
UniProt ID
MLP3B_HUMAN 
Synonyms ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B.a
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [62]
2 Affinity Capture-Western [63]
3 Affinity Capture-Western [49]
4 Affinity Capture-Western [64]
5 Affinity Capture-Western [65]
6 Affinity Capture-Western [66]
7 Yeast two hybrid [49]
Interacting Protein Name Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) Interacting Protein Interacting Protein Info
UniProt ID
GBRL2_HUMAN 
Synonyms ATG8; ATG8C; GATE.16; GATE16; GEF.2; GEF2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [64]
2 Affinity Capture-Western [49]
3 Yeast two hybrid [67]
4 Yeast two hybrid [68]
5 Yeast two hybrid [49]
Interacting Protein Name Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) Interacting Protein Interacting Protein Info
UniProt ID
GBRL1_HUMAN 
Synonyms APG8.LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Co-localization [69]
3 Yeast two hybrid [67]
4 Yeast two hybrid [68]
Other proteins [+] 5 Other proteins +
Interacting Protein Name Next to BRCA1 gene 1 protein (NBR1) Interacting Protein Interacting Protein Info
UniProt ID
NBR1_HUMAN 
Synonyms 1A1.3B; IAI3B; M17S2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Affinity Capture-Western [17]
3 Affinity Capture-Western [18]
4 Reconstituted Complex [21]
Interacting Target Name TAR DNA binding protein 43 (TARDBP) Clinical trial Target Interacting Protein Info
UniProt ID
TADBP_HUMAN 
Synonyms TDP-43; TDP43; TAR DNA-binding protein 43
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Co-localization [71]
3 Reconstituted Complex [40]
Interacting Protein Name Trifunctional enzyme subunit beta (HADHB) Interacting Protein Interacting Protein Info
UniProt ID
ECHB_HUMAN 
Synonyms ECHB; MTPB; TP.BETA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [6]
Interacting Protein Name Protein NipSnap homolog 2 (NIPSNAP2) Interacting Protein Interacting Protein Info
UniProt ID
NIPS2_HUMAN 
Synonyms NIPSNAP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [6]
Interacting Protein Name WD repeat and FYVE domain-containing protein 3 (WDFY3) Interacting Protein Interacting Protein Info
UniProt ID
WDFY3_HUMAN 
Synonyms ALFY; ZFYVE25
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [72]
2 Affinity Capture-Western [73]
References  Top
REF 1 PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5. Autophagy. 2018;14(11):1870-1885.
REF 2 Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Nat Cell Biol. 2015 Jul;17(7):917-29.
REF 3 Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. Protein Cell. 2016 Feb;7(2):114-29.
REF 4 Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells. Acta Pharmacol Sin. 2015 Nov;36(11):1300-7.
REF 5 The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy. J Cell Sci. 2014 Aug 1;127(Pt 15):3280-93.
REF 6 A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy. 2015;11(7):1161-78.
REF 7 The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity. J Immunol. 2009 Feb 15;182(4):2131-40.
REF 8 TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. J Cell Biol. 2015 Sep 14;210(6):973-89.
REF 9 The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. 2000 Apr 3;19(7):1576-86.
REF 10 PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem. 2010 Jan 15;285(3):2077-89.
REF 11 Network organization of the human autophagy system. Nature. 2010 Jul 1;466(7302):68-76.
REF 12 Involvement of selective autophagy mediated by p62/SQSTM1n KLHL3-dependent WNK4 degradation. Biochem J. 2015 Nov 15;472(1):33-41.
REF 13 A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010 Jul;30(13):3275-85.
REF 14 Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator. Cell Death Differ. 2013 Aug;20(8):1101-15.
REF 15 Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol. 2010 Sep;12(9):863-75.
REF 16 Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol. 1998 May;18(5):3069-80.
REF 17 Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. J Biol Chem. 2003 Sep 5;278(36):34568-81.
REF 18 NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo. EMBO J. 2010 Oct 6;29(19):3421-33.
REF 19 Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 4;290(36):21845-56.
REF 20 Sequestosome 1 protects esophageal squamous carcinoma cells from apoptosis via stabilizing SKP2 under serum starvation condition. Oncogene. 2018 Jun;37(24):3260-3274.
REF 21 Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota. J Biol Chem. 2006 Sep 22;281(38):28450-9.
REF 22 Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation. Mol Cell Biol. 2011 Jan;31(1):105-17.
REF 23 p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition. FEBS Lett. 2002 Jan 2;510(1-2):57-61.
REF 24 The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. Mol Cell Biol. 2005 May;25(10):4010-22.
REF 25 PKC-interacting protein ZIP3 is generated by intronic polyadenylation, and is expressed in the brain and retina of the rat. Biochem J. 2011 Jan 1;433(1):43-50.
REF 26 Protein Scaffolds Control Localized Protein Kinase C Activity. J Biol Chem. 2016 Jun 24;291(26):13809-22.
REF 27 PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol Cell. 2003 Jul;12(1):39-50.
REF 28 Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. Sci Signal. 2009 Oct 20;2(93):ra66.
REF 29 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 30 Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res. 2008 Sep;7(9):3879-89.
REF 31 p62 functions as a p38 MAP kinase regulator. Biochem Biophys Res Commun. 2000 Mar 16;269(2):521-5.
REF 32 Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1. J Biochem. 2008 Jun;143(6):765-72.
REF 33 Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015 Feb 27;11(2):e1004987.
REF 34 Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014 Sep;281(17):3816-27.
REF 35 Autophagic degradation of the inhibitory p53 isoform 133p53 as a regulatory mechanism for p53-mediated senescence. Nat Commun. 2014 Aug 21;5:4706.
REF 36 Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Mol Cell. 2006 Jun 23;22(6):731-40.
REF 37 Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell. 2011 Oct 21;44(2):279-89.
REF 38 Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease. Mol Neurobiol. 2015 Dec;52(3):1180-1189.
REF 39 Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Autophagy. 2013 Oct;9(10):1591-603.
REF 40 p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions. J Neurosci Res. 2012 Oct;90(10):2034-42.
REF 41 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol. 2004 Sep;24(18):8055-68.
REF 42 Evaluation of selected binding domains for the analysis of ubiquitinated proteomes. J Am Soc Mass Spectrom. 2013 Aug;24(8):1214-23.
REF 43 Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin. PLoS One. 2014 Dec 10;9(12):e114964.
REF 44 Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2018;14(2):347-358.
REF 45 The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J Cell Biol. 2017 May 1;216(5):1301-1320.
REF 46 Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells. Sci Rep. 2017 Sep 26;7(1):12307.
REF 47 Cigarette smoke induced autophagy-impairment regulates AMD pathogenesis mechanisms in ARPE-19 cells. PLoS One. 2017 Aug 2;12(8):e0182420.
REF 48 Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Res. 2017 May;27(5):657-674.
REF 49 A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell. 2009 Feb 27;33(4):505-16.
REF 50 Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function. Biochim Biophys Acta. 2014 Jul;1842(7):992-1000.
REF 51 Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux. Autophagy. 2011 Jan;7(1):51-60.
REF 52 The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells. Autophagy. 2015;11(5):812-32.
REF 53 Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination. Cell Rep. 2017 Apr 4;19(1):188-202.
REF 54 Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar;17(3):262-75.
REF 55 Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery. EMBO Rep. 2013 Apr;14(4):373-81.
REF 56 Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clin Sci (Lond). 2013 Feb;124(3):203-14.
REF 57 RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem Biophys Res Commun. 2015 Jan 2;456(1):298-304.
REF 58 Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells. 2008 Dec;13(12):1211-8.
REF 59 p62/SQSTM1 prominently accumulates in renal proximal tubules in nephropathic cystinosis. Pediatr Nephrol. 2012 Nov;27(11):2137-2144.
REF 60 Autophagy induced by calcium phosphate precipitates targets damaged endosomes. J Biol Chem. 2014 Apr 18;289(16):11162-74.
REF 61 The selective autophagy receptor p62 forms a flexible filamentous helical scaffold. Cell Rep. 2015 May 5;11(5):748-58.
REF 62 p62 sequestosome 1/light chain 3b complex confers cytoprotection on lung epithelial cells after hyperoxia. Am J Respir Cell Mol Biol. 2013 Apr;48(4):489-96.
REF 63 Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer. Sci Rep. 2017 Aug 30;7(1):10078.
REF 64 LC3B is indispensable for selective autophagy of p62 but not basal autophagy. Biochem Biophys Res Commun. 2014 Mar 28;446(1):309-15.
REF 65 E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I. PLoS One. 2013 Sep 4;8(9):e73229.
REF 66 p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7490-E7499.
REF 67 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 68 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 69 GABARAPL1 negatively regulates Wnt/-catenin signaling by mediating Dvl2 degradation through the autophagy pathway. Cell Physiol Biochem. 2011;27(5):503-12.
REF 70 Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis. Acta Neuropathol. 2011 Nov;122(5):627-36.
REF 71 White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin. Acta Neuropathol. 2008 Aug;116(2):183-91.
REF 72 Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts. Biochem Biophys Res Commun. 2010 Nov 19;402(3):543-8.
REF 73 p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy. 2010 Apr;6(3):330-44.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.