Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Channel conductance-controlling ATPase (CFTR) | Successful | Target Info | ||
| UniProt ID | CFTR_HUMAN | ||||
| Gene Name | CFTR | ||||
| Gene ID | 1080 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [1] | |
| cAMP-dependent chloride channel (CFTR) | Target Info | PPI Info | [2] | ||
| Interacting Clinical trial Target(s) | Valosin-containing protein p97 (VCP) | Target Info | PPI Info | [1] | |
| Interacting Literature-reported Target(s) | Lipopolysaccharide-associated protein 1 (HSPA8) | Target Info | PPI Info | [3] | |
| Sequestosome-1 p62 (SQSTM1) | Target Info | PPI Info | [4] | ||
| Cytovillin (EZR) | Target Info | PPI Info | [5] | ||
| Heat shock protein 40 (HSP40) | Target Info | PPI Info | [5] | ||
| PDZ domain containing-protein (PDZK1) | Target Info | PPI Info | [6] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol. 2007 Jun;36(6):706-14. | ||||
| REF 2 | Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell. 2006 Nov 17;127(4):803-15. | ||||
| REF 3 | The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol. 2001 Jan;3(1):100-5. | ||||
| REF 4 | Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator. Cell Death Differ. 2013 Aug;20(8):1101-15. | ||||
| REF 5 | 508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 2015 Dec 24;528(7583):510-6. | ||||
| REF 6 | The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins. J Biol Chem. 2003 Feb 21;278(8):6440-9. | ||||
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