Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T55654 Target Info
Target Name cAMP-dependent chloride channel (CFTR)
Synonyms cAMPdependent chloride channel; Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; ATPbinding cassette subfamily C member 7; ATP-binding cassette sub-family C member 7; ABCC7
Target Type Successful Target
Gene Name CFTR
Biochemical Class ABC transporter
UniProt ID
CFTR_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 3 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Affinity Capture-Western [1]
Interacting Protein Name Unconventional myosin-VI (MYO6) Interacting Protein Interacting Protein Info
UniProt ID
MYO6_HUMAN 
Synonyms DFNA22; DFNB37
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [8]
Interacting Protein Name Ras-related protein Rab-5A (RAB5A) Interacting Protein Interacting Protein Info
UniProt ID
RAB5A_HUMAN 
Synonyms RAB5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [9]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase AMFR (AMFR) Interacting Protein Interacting Protein Info
UniProt ID
AMFR_HUMAN 
Synonyms GP78; RNF45
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [6]
Adapter proteins [+] 2 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-fractionation [10]
3 Co-localization [11]
Interacting Protein Name Disabled homolog 2 (DAB2) Interacting Protein Interacting Protein Info
UniProt ID
DAB2_HUMAN 
Synonyms DOC.2; DOC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [8]
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Protein Name Ezrin-radixin-moesin-binding phosphoprotein 50 (SLC9A3R1) Interacting Protein Interacting Protein Info
UniProt ID
NHRF1_HUMAN 
Synonyms EBP50; NHERF; NHERF.1; NHERF1; NPHLOP2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [12]
4 Affinity Capture-Western [13]
5 Protein-peptide [14]
6 Reconstituted Complex [15]
7 Reconstituted Complex [16]
Interacting Protein Name SRY-interacting protein 1 (SLC9A3R2) Interacting Protein Interacting Protein Info
UniProt ID
NHRF2_HUMAN 
Synonyms E3KARP; NHE3RF2; NHERF.2; NHERF2; OCTS2; SIP.1; SIP1; TKA.1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [17]
4 Reconstituted Complex [17]
Heat shock proteins [+] 4 Heat shock proteins +
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [19]
6 Affinity Capture-Western [1]
7 Affinity Capture-Western [20]
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [1]
4 Affinity Capture-Western [21]
5 Affinity Capture-Western [22]
6 Affinity Capture-Western [23]
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Affinity Capture-Western [21]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [24]
4 Affinity Capture-Western [25]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Protein Name Derlin-1 (DERL1) Interacting Protein Interacting Protein Info
UniProt ID
DERL1_HUMAN 
Synonyms DER.1; DER1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [7]
Other proteins [+] 7 Other proteins +
Interacting Protein Name Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) Interacting Protein Interacting Protein Info
UniProt ID
AHSA1_HUMAN 
Synonyms AHA1; C14orf3; p38
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [21]
Interacting Protein Name Calnexin (CANX) Interacting Protein Interacting Protein Info
UniProt ID
CALX_HUMAN 
Synonyms CNX; IP90; P90
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [22]
Interacting Protein Name DnaJ homolog subfamily A member 1 (DNAJA1) Interacting Protein Interacting Protein Info
UniProt ID
DNJA1_HUMAN 
Synonyms DJ.2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ.2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [18]
Interacting Protein Name DnaJ homolog subfamily C member 5 (DNAJC5) Interacting Protein Interacting Protein Info
UniProt ID
DNJC5_HUMAN 
Synonyms CLN4; CLN4B; CSP; DNAJC5A; NCL
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Affinity Capture-Western [19]
3 Reconstituted Complex [26]
Interacting Target Name Heat shock protein 40 (HSP40) Literature-reported Target Interacting Protein Info
UniProt ID
DNJB1_HUMAN 
Synonyms HSP40; Heat shock 40 kDa protein 1; HDJ-1; DNAJB1; DnaJ protein homolog 1; DnaJ homolog subfamily B member 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [18]
Interacting Target Name Cytovillin (EZR) Literature-reported Target Interacting Protein Info
UniProt ID
EZRI_HUMAN 
Synonyms Villin-2; VIL2; p81; Cytovillin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [17]
Interacting Target Name PDZ domain containing-protein (PDZK1) Literature-reported Target Interacting Protein Info
UniProt ID
NHRF3_HUMAN 
Synonyms Sodium-hydrogen exchanger regulatory factor 3; PDZD1; PDZ domain-containing protein 1; NHERF-3; NHERF3; NaPi-Cap1; Na/Pi cotransporter C-terminal-associated protein 1; Na(+)/H(+) exchanger regulatory factor 3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Multi-PDZ domain containing adaptor protein; CFTR-associated protein of 70 kDa; CAP70
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Reconstituted Complex [27]
References  Top
REF 1 VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol. 2007 Jun;36(6):706-14.
REF 2 Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell. 2006 Nov 17;127(4):803-15.
REF 3 508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 2015 Dec 24;528(7583):510-6.
REF 4 Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. J Biol Chem. 2006 Jun 23;281(25):17369-78.
REF 5 Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. Mol Biol Cell. 2008 Apr;19(4):1328-36.
REF 6 Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1. Int J Biochem Cell Biol. 2010 Jan;42(1):167-73.
REF 7 Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants. J Biol Chem. 2006 Dec 1;281(48):36856-63.
REF 8 Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. J Biol Chem. 2010 May 28;285(22):17177-87.
REF 9 The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. J Biol Chem. 2009 Jul 10;284(28):18778-89.
REF 10 Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator. Cell Death Differ. 2013 Aug;20(8):1101-15.
REF 11 Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol. 2010 Sep;12(9):863-75.
REF 12 Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR). FEBS Lett. 1998 May 1;427(1):103-8.
REF 13 The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. J Biol Chem. 2002 Dec 27;277(52):50503-9.
REF 14 An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. J Biol Chem. 1998 Jul 31;273(31):19797-801.
REF 15 C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. Biochem Biophys Res Commun. 2003 Mar 14;302(3):454-61.
REF 16 A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8496-501.
REF 17 E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells. J Biol Chem. 2000 Sep 22;275(38):29539-46.
REF 18 The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. EMBO J. 1999 Mar 15;18(6):1492-505.
REF 19 S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in e... Mol Pharmacol. 2006 Oct;70(4):1435-42.
REF 20 A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase. J Cell Biol. 2004 Dec 20;167(6):1075-85.
REF 21 Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J. 2008 Sep;22(9):3255-63.
REF 22 Assembly and misassembly of cystic fibrosis transmembrane conductance regulator: folding defects caused by deletion of F508 occur before and after the calnexin-dependent association of membrane spanning domain (MSD) 1 and MSD2. Mol Biol Cell. 2008 Nov;19(11):4570-9.
REF 23 Cysteine string protein promotes proteasomal degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation. J Biol Chem. 2009 Feb 13;284(7):4168-78.
REF 24 Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway. Mol Biol Cell. 2013 Jan;24(2):74-84.
REF 25 Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation. J Biol Chem. 2016 Jan 22;291(4):2004-17.
REF 26 Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2002 Aug 9;277(32):28948-58.
REF 27 The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins. J Biol Chem. 2003 Feb 21;278(8):6440-9.

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