Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T96704 Target Info
Target Name Heat shock protein 40 (HSP40)
Synonyms Heat shock 40 kDa protein 1; HSP40; HDJ-1; DnaJ protein homolog 1; DnaJ homolog subfamily B member 1; DNAJB1
Target Type Literature-reported Target
Gene Name DNAJB1
Biochemical Class Heat shock protein
UniProt ID
DNJB1_HUMAN 
Target Interacting Proteins  Top
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Target Name cAMP-dependent chloride channel (CFTR) Successful Target Interacting Protein Info
UniProt ID
CFTR_HUMAN 
Synonyms Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; cAMP-dependent chloride channel; cAMPdependent chloride channel; ATP-binding cassette sub-family C member 7; ATPbinding cassette subfamily C member 7; ABCC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
References  Top
REF 1 ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation. Nat Commun. 2016 Oct 6;7:12882.
REF 2 Molecular and functional characterization of HSC54, a novel variant of human heat-shock cognate protein 70. Mol Pharmacol. 2000 Dec;58(6):1257-63.
REF 3 508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 2015 Dec 24;528(7583):510-6.
REF 4 The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. EMBO J. 1999 Mar 15;18(6):1492-505.

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