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Protein General Information (TTD Target) |
Top |
Full Name |
E3 ubiquitin-protein ligase COP1 (RFWD2)
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Literature-reported
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Target Info
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UniProt ID |
COP1_HUMAN
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Gene Name |
RFWD2
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Gene ID |
64326
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Interacting TTD Target Information |
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Interacting Literature-reported Target(s) |
E3 ubiquitin-protein ligase COP1 (RFWD2) |
Target Info
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PPI Info
|
[1] |
Interacting Clinical trial Target(s) |
Cellular tumor antigen p53 (TP53) |
Target Info
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PPI Info
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[2] |
Interacting Discontinued Target(s) |
Transcription factor AP-1 (JUN) |
Target Info
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PPI Info
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[1] |
References |
Top |
REF 1 |
Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity. J Biol Chem. 2003 May 30;278(22):19682-90.
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REF 2 |
The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature. 2004 May 6;429(6987):86-92.
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