Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T88786 Target Info
Target Name N-myc proto-oncogene protein (MYCN)
Synonyms bHLHe37; NMYC; N-myc; Class E basic helix-loop-helix protein 37
Target Type Literature-reported Target
Gene Name MYCN
UniProt ID
MYCN_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Target Name Aurora kinase A (AURKA) Clinical trial Target Interacting Protein Info
UniProt ID
AURKA_HUMAN 
Synonyms STK6; STK15; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; IAK1; hARK1; BTAK; Breast tumor-amplified kinase; AYK1; Aurora-related kinase 1; Aurora-A; Aurora/IPL1-related kinase 1; Aurora 2; AURA; ARK-1; ARK1; AIRK1; AIK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-crystal Structure [2]
3 Reconstituted Complex [2]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Protein max (MAX) Interacting Protein Interacting Protein Info
UniProt ID
MAX_HUMAN 
Synonyms bHLHd4
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [5]
5 Co-purification [5]
6 Protein-Fragment Complementation Assay [6]
7 Reconstituted Complex [5]
8 Reconstituted Complex [7]
Interacting Protein Name Zinc finger and BTB domain-containing protein 17 (ZBTB17) Interacting Protein Interacting Protein Info
UniProt ID
ZBT17_HUMAN 
Synonyms MIZ.1; ZNF151; ZNF60; pHZ.67
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
Other proteins [+] 1 Other proteins +
Interacting Target Name F-box and WD-40 domain protein 7 (Fbxw7) Literature-reported Target Interacting Protein Info
UniProt ID
FBXW7_HUMAN 
Synonyms SEL-10; SEL10; hCdc4; hAgo; FBX30; FBW7; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; F-box protein Fbxw6; F-box protein FBX30; F-box protein FBW7; F-box and WD-40 domain-containing protein 7; Archipelago homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
References  Top
REF 1 Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2009 Jan 6;15(1):67-78.
REF 2 Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731.
REF 3 The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol. 2008 Jun;10(6):643-53.
REF 4 p14ARF interacts with N-Myc and inhibits its transcriptional activity. FEBS Lett. 2007 Mar 6;581(5):821-5.
REF 5 The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells. EMBO J. 1991 Dec;10(12):3703-12.
REF 6 Targeting of the MYCN protein with small molecule c-MYC inhibitors. PLoS One. 2014 May 23;9(5):e97285.
REF 7 Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science. 1991 Mar 8;251(4998):1211-7.
REF 8 Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma. Clin Cancer Res. 2011 Nov 1;17(21):6681-92.
REF 9 A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF. Cancer Res. 2011 Jan 15;71(2):404-12.

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