Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Aurora kinase A (AURKA) | Clinical trial | Target Info | ||
| UniProt ID | AURKA_HUMAN | ||||
| Gene Name | AURKA | ||||
| Gene ID | 6790 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Aurora kinase A (AURKA) | Target Info | PPI Info | [1] | |
| Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [2] | ||
| Interacting Patented-recorded Target(s) | von Hippel-Lindau disease tumor suppressor (VHL) | Target Info | PPI Info | [3] | |
| Interacting Literature-reported Target(s) | Large tumor suppressor homolog 2 (LATS2) | Target Info | PPI Info | [4] | |
| Hepatocellular carcinoma-associated antigen 90 (TPX2) | Target Info | PPI Info | [1] | ||
| N-myc proto-oncogene protein (MYCN) | Target Info | PPI Info | [5] | ||
| Transforming acidic coiled-coil protein 3 (TACC3) | Target Info | PPI Info | [6] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 2010 Apr 30;328(5978):593-9. | ||||
| REF 2 | Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J. 2002 Sep 2;21(17):4491-9. | ||||
| REF 3 | Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC). PLoS One. 2013 Jun 13;8(6):e67071. | ||||
| REF 4 | The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle. 2011 Aug 15;10(16):2724-36. | ||||
| REF 5 | Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2009 Jan 6;15(1):67-78. | ||||
| REF 6 | Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004 Jan;3(1):93-104. | ||||
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