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| Target General Information |
Top |
| Target ID |
T27600 |
Target Info
|
| Target Name |
Transforming acidic coiled-coil protein 3 (TACC3) |
| Synonyms |
Transforming acidic coiled-coil-containing protein 3; ERIC1; ERIC-1 |
| Target Type |
Literature-reported Target |
| Gene Name |
TACC3 |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Beta-transducin repeats |
[+] 1 Beta-transducin repeats |
+ |
| Interacting Protein Name |
Fizzy-related protein homolog (FZR1) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1 |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Reconstituted Complex |
[1] |
| 4 |
Yeast two hybrid |
[1] |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Aurora kinase A (AURKA) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
STK6; STK15; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; IAK1; hARK1; BTAK; Breast tumor-amplified kinase; AYK1; Aurora-related kinase 1; Aurora-A; Aurora/IPL1-related kinase 1; Aurora 2; AURA; ARK-1; ARK1; AIRK1; AIK |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[3] |
| 2 |
Biochemical Activity |
[4] |
| 3 |
Yeast two hybrid |
[4] |
| References |
Top |
| REF 1 |
Cdh1 controls the stability of TACC3. Cell Cycle. 2009 Nov 1;8(21):3537-44.
|
| REF 2 |
Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway. Cell Death Dis. 2014 Nov 6;5:e1513.
|
| REF 3 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
|
| REF 4 |
Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004 Jan;3(1):93-104.
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