Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T87675 | Target Info | |||
Target Name | Aurora kinase A (AURKA) | ||||
Synonyms | hARK1; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; STK6; STK15; IAK1; Breast tumor-amplified kinase; BTAK; Aurora/IPL1-related kinase 1; Aurora-related kinase 1; Aurora-A; Aurora 2; AYK1; AURA; ARK1; ARK-1; AIRK1; AIK | ||||
Target Type | Clinical trial Target | ||||
Gene Name | AURKA | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acyltransferases | [+] 1 Acyltransferases | + | |||
Interacting Protein Name | Breast cancer type 1 susceptibility protein (BRCA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Affinity Capture-Western | [2] | |||
3 | Biochemical Activity | [1] | |||
4 | Reconstituted Complex | [1] | |||
Kinases | [+] 1 Kinases | + | |||
Interacting Target Name | Large tumor suppressor homolog 2 (LATS2) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Warts-like kinase; Serine/threonine-protein kinase LATS2; Serine/threonine-protein kinase kpm; KPM; Kinase phosphorylated during mitosis protein | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [3] | |||
2 | Affinity Capture-Western | [4] | |||
3 | Biochemical Activity | [4] | |||
4 | Fluorescence Resonance Energy Transfer | [5] | |||
Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
Interacting Target Name | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 | ||||
Evidence Score (E-score) | 7 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [6] | |||
2 | Affinity Capture-MS | [7] | |||
3 | Affinity Capture-Western | [8] | |||
4 | Affinity Capture-Western | [9] | |||
5 | Biochemical Activity | [10] | |||
6 | Reconstituted Complex | [9] | |||
7 | Yeast two hybrid | [8] | |||
Transcription regulators | [+] 1 Transcription regulators | + | |||
Interacting Target Name | N-myc proto-oncogene protein (MYCN) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | N-myc; NMYC; Class E basic helix-loop-helix protein 37; bHLHe37 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [11] | |||
2 | Co-crystal Structure | [12] | |||
3 | Reconstituted Complex | [12] | |||
Other proteins | [+] 5 Other proteins | + | |||
Interacting Target Name | Hepatocellular carcinoma-associated antigen 90 (TPX2) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Restricted expression proliferation-associated protein 100; Protein fls353; Hepatocellular carcinoma-associated antigen 90; Hepatocellular carcinoma-associated antigen 519; HCA519; DIL-2; DIL2; Differentially expressed in cancerous and non-cancerous lung cells 2; C20orf2; C20orf1 | ||||
Evidence Score (E-score) | 8 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [13] | |||
2 | Affinity Capture-MS | [6] | |||
3 | Affinity Capture-MS | [7] | |||
4 | Affinity Capture-Western | [14] | |||
5 | Affinity Capture-Western | [2] | |||
6 | Affinity Capture-Western | [15] | |||
7 | Affinity Capture-Western | [16] | |||
8 | Reconstituted Complex | [14] | |||
Interacting Protein Name | Inner centromere protein (INCENP) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [15] | |||
2 | Affinity Capture-Western | [16] | |||
3 | Biochemical Activity | [16] | |||
4 | Reconstituted Complex | [15] | |||
5 | Reconstituted Complex | [16] | |||
Interacting Target Name | Transforming acidic coiled-coil protein 3 (TACC3) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Transforming acidic coiled-coil-containing protein 3; ERIC-1; ERIC1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [6] | |||
2 | Affinity Capture-MS | [7] | |||
3 | Biochemical Activity | [17] | |||
4 | Yeast two hybrid | [17] | |||
Interacting Target Name | von Hippel-Lindau disease tumor suppressor (VHL) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | pVHL; Protein G7 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [18] | |||
2 | Biochemical Activity | [19] | |||
Interacting Protein Name | Transcription elongation factor A protein-like 2 (TCEAL2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MY0876G05; WEX1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [20] | |||
2 | Reconstituted Complex | [21] |
References | Top | ||||
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REF 1 | BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 2004 May 7;279(19):19643-8. | ||||
REF 2 | Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol. 2011 Nov;9(11):e1001199. | ||||
REF 3 | The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle. 2011 Aug 15;10(16):2724-36. | ||||
REF 4 | The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells. 2004 May;9(5):383-97. | ||||
REF 5 | OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860. | ||||
REF 6 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 7 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. | ||||
REF 8 | Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J. 2002 Sep 2;21(17):4491-9. | ||||
REF 9 | Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 2004 Jan;36(1):55-62. | ||||
REF 10 | A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2. Biochim Biophys Acta. 2013 Feb;1834(2):508-15. | ||||
REF 11 | Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2009 Jan 6;15(1):67-78. | ||||
REF 12 | Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731. | ||||
REF 13 | Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 2010 Apr 30;328(5978):593-9. | ||||
REF 14 | Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol. 2002 Aug 19;158(4):617-23. | ||||
REF 15 | Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cell Cycle. 2008 Sep 1;7(17):2691-704. | ||||
REF 16 | A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6939-44. | ||||
REF 17 | Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004 Jan;3(1):93-104. | ||||
REF 18 | Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Oncogene. 2017 Jun 15;36(24):3450-3463. | ||||
REF 19 | Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC). PLoS One. 2013 Jun 13;8(6):e67071. | ||||
REF 20 | LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531. | ||||
REF 21 | Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. Oncogenesis. 2017 Feb 20;6(2):e298. |
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