Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Target Regulators
References
Drug Binding Sites of Target  Top
Ligand Name: Adenosine monophosphate Ligand Info
Structure Description TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 8-34, and in complex with AMP-PNP PDB:6VPM
Method X-ray diffraction Resolution 1.58 Å Mutation No [2]
PDB Sequence
MSYSYDAPSD
15
FINFSSKRQW
128
ALEDFEIGRP
138
LGKGKFGNVY
148
LAREKQSKFI
158

LALKVLFKAQ
168
LEKAGVEHQL
178
RREVEIQSHL
188
RHPNILRLYG
198
YFHDATRVYL
208

ILEYAPLGTV
218
YRELQKLSKF
228
DEQRTATYIT
238
ELANALSYCH
248
SKRVIHRDIK
258

PENLLLGSAG
268
ELKIADFGWS
278
VHAPTLCGTL
293
DYLPPEMIEG
303
RMHDEKVDLW
313

SLGVLCYEFL
323
VGKPPFEANT
333
YQETYKRISR
343
VEFTFPDFVT
353
EGARDLISRL
363

LKHNPSQRPM
373
LREVLEHPWI
383
TANSSK
Residue
Distance (Å)
LEU139
3.526
GLY140
3.550
LYS141
3.841
GLY142
4.293
VAL147
3.746
ALA160
3.705
LYS162
3.140
Residue
Distance (Å)
LEU194
3.460
LEU210
3.934
GLU211
2.618
TYR212
3.379
ALA213
3.004
THR217
3.457
LEU263
3.719
Ligand Name: Ammonia Ligand Info
Structure Description Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2 PDB:5LXM
Method X-ray diffraction Resolution 2.08 Å Mutation Yes [3]
PDB Sequence
SSYSYDAPSD
15
FINFSSLTQN
30
IDSWFEKANE
42
N
Residue
Distance (Å)
ALA39
2.831
GLU42
3.535
Residue
Distance (Å)
ASN43
1.330
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
Degree 32 Degree centrality 3.44E-03 Betweenness centrality 2.39E-04
Closeness centrality 2.15E-01 Radiality 1.38E+01 Clustering coefficient 6.31E-01
Neighborhood connectivity 4.51E+01 Topological coefficient 1.50E-01 Eccentricity 13
Download Click to Download the Full PPI Network of This Target

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