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| Target General Information |
Top |
| Target ID |
T92966 |
Target Info
|
| Target Name |
Hepatocellular carcinoma-associated antigen 90 (TPX2) |
| Synonyms |
Restricted expression proliferation-associated protein 100; Protein fls353; Hepatocellular carcinoma-associated antigen 519; HCA519; Differentially expressed in cancerous and non-cancerous lung cells 2; DIL2; DIL-2; C20orf2; C20orf1 |
| Target Type |
Literature-reported Target |
| Gene Name |
TPX2 |
| Biochemical Class |
TPX2 family |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Aurora kinase A (AURKA) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
STK6; STK15; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; IAK1; hARK1; BTAK; Breast tumor-amplified kinase; AYK1; Aurora-related kinase 1; Aurora-A; Aurora/IPL1-related kinase 1; Aurora 2; AURA; ARK-1; ARK1; AIRK1; AIK |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 2010 Apr 30;328(5978):593-9.
|
| REF 2 |
Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol. 2002 Aug 19;158(4):617-23.
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