Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T18390 Target Info
Target Name Large tumor suppressor homolog 2 (LATS2)
Synonyms Warts-like kinase; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; KPM
Target Type Literature-reported Target
Gene Name LATS2
Biochemical Class Kinase
UniProt ID
LATS2_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name LIM domain-containing protein ajuba (AJUBA) Interacting Protein Interacting Protein Info
UniProt ID
AJUBA_HUMAN 
Synonyms JUB
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [1]
4 Yeast two hybrid [1]
Interacting Protein Name LIM domain-containing protein 1 (LIMD1) Interacting Protein Interacting Protein Info
UniProt ID
LIMD1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [2]
3 Proximity Label-MS [3]
Kinases [+] 3 Kinases +
Interacting Target Name Aurora kinase A (AURKA) Clinical trial Target Interacting Protein Info
UniProt ID
AURKA_HUMAN 
Synonyms STK6; STK15; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; IAK1; hARK1; BTAK; Breast tumor-amplified kinase; AYK1; Aurora-related kinase 1; Aurora-A; Aurora/IPL1-related kinase 1; Aurora 2; AURA; ARK-1; ARK1; AIRK1; AIK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Biochemical Activity [5]
3 Fluorescence Resonance Energy Transfer [6]
Interacting Target Name MST-1 protein kinase (STK4) Literature-reported Target Interacting Protein Info
UniProt ID
STK4_HUMAN 
Synonyms STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4; MST1/N; MST1/C; MST-1; MST1; Mammalian STE20-like protein kinase 1; KRS2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Fluorescence Resonance Energy Transfer [7]
Interacting Protein Name Serine/threonine-protein kinase 3 (STK3) Interacting Protein Interacting Protein Info
UniProt ID
STK3_HUMAN 
Synonyms KRS1; MST2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [8]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) Interacting Protein Interacting Protein Info
UniProt ID
USP9X_HUMAN 
Synonyms DFFRX; FAF; FAM; MRX99
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [10]
4 Affinity Capture-Western [9]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Yes-associated protein 1 (YAP1) Literature-reported Target Interacting Protein Info
UniProt ID
YAP1_HUMAN 
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [12]
3 Affinity Capture-Western [13]
4 Affinity Capture-Western [14]
5 Biochemical Activity [15]
6 Biochemical Activity [16]
7 Biochemical Activity [17]
8 Biochemical Activity [9]
9 Biochemical Activity [18]
10 Biochemical Activity [8]
11 Biochemical Activity [19]
12 Biochemical Activity [20]
13 Fluorescence Resonance Energy Transfer [7]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Protein Name Anaphase-promoting complex subunit 1 (ANAPC1) Interacting Protein Interacting Protein Info
UniProt ID
APC1_HUMAN 
Synonyms APC1; MCPR; TSG24
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [9]
4 Co-localization [9]
5 Proximity Label-MS [3]
Interacting Protein Name Anaphase-promoting complex subunit 5 (ANAPC5) Interacting Protein Interacting Protein Info
UniProt ID
APC5_HUMAN 
Synonyms APC5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [9]
4 Proximity Label-MS [3]
Other proteins [+] 6 Other proteins +
Interacting Target Name Angiomotin (AMOT) Literature-reported Target Interacting Protein Info
UniProt ID
AMOT_HUMAN 
Synonyms KIAA1071
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Biochemical Activity [21]
3 Biochemical Activity [22]
4 Biochemical Activity [23]
5 Proximity Label-MS [3]
Interacting Protein Name MOB kinase activator 1A (MOB1A) Interacting Protein Interacting Protein Info
UniProt ID
MOB1A_HUMAN 
Synonyms C2orf6; MATS1; MOB1; MOBK1B; MOBKL1B; Mob4B
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [24]
4 Affinity Capture-Western [25]
5 Proximity Label-MS [3]
Interacting Protein Name Angiomotin-like protein 2 (AMOTL2) Interacting Protein Interacting Protein Info
UniProt ID
AMOL2_HUMAN 
Synonyms LCCP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Affinity Capture-Western [17]
3 Proximity Label-MS [3]
Interacting Protein Name Apoptosis-stimulating of p53 protein 1 (PPP1R13B) Interacting Protein Interacting Protein Info
UniProt ID
ASPP1_HUMAN 
Synonyms ASPP1; p53BP2.like; p85
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [13]
3 Proximity Label-MS [3]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Proximity Label-MS [3]
Interacting Protein Name Junctional protein associated with coronary artery disease (JCAD) Interacting Protein Interacting Protein Info
UniProt ID
JCAD_HUMAN 
Synonyms JCAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Proximity Label-MS [3]
References  Top
REF 1 LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. FEBS Lett. 2006 Feb 6;580(3):782-8.
REF 2 Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol. 2010 Apr 13;20(7):657-62.
REF 3 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal. 2013 Nov 19;6(302):rs15.
REF 4 The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle. 2011 Aug 15;10(16):2724-36.
REF 5 The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells. 2004 May;9(5):383-97.
REF 6 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 7 Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform. J Mol Cell Biol. 2016 Jun;8(3):271-81.
REF 8 Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. Genes Cells. 2009 Dec;14(12):1369-81.
REF 9 Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway. J Biol Chem. 2018 Jan 26;293(4):1178-1191.
REF 10 Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. Cancer Res. 2017 Sep 15;77(18):4921-4933.
REF 11 Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res. 2008 Apr 15;68(8):2789-94.
REF 12 Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP. Genes Dev. 2010 Nov 1;24(21):2430-9.
REF 13 The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. Genes Dev. 2010 Nov 1;24(21):2420-9.
REF 14 Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem. 2008 Oct 10;283(41):27534-46.
REF 15 Hippo pathway-dependent and -independent roles of RASSF6. Sci Signal. 2009 Sep 29;2(90):ra59.
REF 16 Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor. Mol Biol Cell. 2011 Oct;22(19):3725-33.
REF 17 Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. EMBO Rep. 2016 Jan;17(1):64-78.
REF 18 Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Sci Signal. 2015 Feb 10;8(363):ra14.
REF 19 Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17;150(4):780-91.
REF 20 Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1. Cancer Res. 2017 Sep 15;77(18):4868-4880.
REF 21 Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17368-73.
REF 22 Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation. J Biol Chem. 2013 Dec 27;288(52):37296-307.
REF 23 Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J Biol Chem. 2013 Nov 22;288(47):34041-51.
REF 24 Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. Mol Cell Biol. 2010 Sep;30(18):4507-20.
REF 25 The characterisation of LATS2 kinase regulation in Hippo-YAP signalling. Cell Signal. 2016 May;28(5):488-497.
REF 26 LATS2 suppresses oncogenic Wnt signaling by disrupting -catenin/BCL9 interaction. Cell Rep. 2013 Dec 26;5(6):1650-63.
REF 27 JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity. Cancer Res. 2017 Oct 1;77(19):5287-5300.

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