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| Protein General Information (TTD Target) |
Top |
| Full Name |
DNA (cytosine-5)-methyltransferase 3A (DNMT3A)
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Patented-recorded
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Target Info
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| UniProt ID |
DNM3A_HUMAN
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| Gene Name |
DNMT3A
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| Gene ID |
1788
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| Interacting TTD Target Information |
Top |
| Interacting Successful Target(s) |
Histone deacetylase 1 (HDAC1) |
Target Info
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PPI Info
|
[1] |
| Interacting Clinical trial Target(s) |
DNA [cytosine-5]-methyltransferase 3B (DNMT3B) |
Target Info
|
PPI Info
|
[2] |
| Interacting Patented-recorded Target(s) |
DNA [cytosine-5]-methyltransferase 3-like (DNMT3L) |
Target Info
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PPI Info
|
[3] |
| Interacting Literature-reported Target(s) |
Proto-oncogene c-Myc (MYC) |
Target Info
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PPI Info
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[4] |
| References |
Top |
| REF 1 |
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J. 2001 May 15;20(10):2536-44.
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| REF 2 |
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 2004 Jan 29;32(2):598-610.
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| REF 3 |
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002 Apr;129(8):1983-93.
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| REF 4 |
Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005 Jan 26;24(2):336-46.
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