Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T80487 Target Info
Target Name DNA [cytosine-5]-methyltransferase 3-like (DNMT3L)
Synonyms DNA (cytosine-5)-methyltransferase 3-like
Target Type Patented-recorded Target
Gene Name DNMT3L
UniProt ID
DNM3L_HUMAN 
Target Interacting Proteins  Top
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [1]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 3A (DNMT3A) Patented-recorded Target Interacting Protein Info
UniProt ID
DNM3A_HUMAN 
Synonyms M.HsaIIIA; Dnmt3a; DNA MTase HsaIIIA; DNA methyltransferase HsaIIIA; DNA (cytosine-5)-methyltransferase 3A
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Co-localization [6]
5 Reconstituted Complex [7]
6 Reconstituted Complex [4]
7 Yeast two hybrid [8]
8 Yeast two hybrid [5]
Interacting Target Name DNA [cytosine-5]-methyltransferase 3B (DNMT3B) Clinical trial Target Interacting Protein Info
UniProt ID
DNM3B_HUMAN 
Synonyms M.HsaIIIB; Dnmt3b; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA methyltransferase 3B; DNA (cytosine-5)-methyltransferase 3B
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Co-localization [6]
4 Reconstituted Complex [7]
5 Reconstituted Complex [4]
6 Yeast two hybrid [8]
References  Top
REF 1 Dnmt3L is a transcriptional repressor that recruits histone deacetylase. Nucleic Acids Res. 2002 Sep 1;30(17):3831-8.
REF 2 Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. Nucleic Acids Res. 2002 Aug 15;30(16):3602-8.
REF 3 Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002 Apr;129(8):1983-93.
REF 4 DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction. J Biol Chem. 2004 Jun 25;279(26):27816-23.
REF 5 Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family. J Cell Biochem. 2005 Aug 1;95(5):902-17.
REF 6 DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFB complex in the (de-)methylation of TRAF1. Biochimie. 2014 Sep;104:36-49.
REF 7 DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 2007 Aug 9;448(7154):714-7.
REF 8 Interactions within the mammalian DNA methyltransferase family. BMC Mol Biol. 2003 May 30;4:7.

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