Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | DNA (cytosine-5)-methyltransferase 3B (DNMT3B) | Clinical trial | Target Info | ||
| UniProt ID | DNM3B_HUMAN | ||||
| Gene Name | DNMT3B | ||||
| Gene ID | 1789 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Histone deacetylase 1 (HDAC1) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Histone deacetylase 2 (HDAC2) | Target Info | PPI Info | [1] | |
| DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Target Info | PPI Info | [2] | ||
| Interacting Patented-recorded Target(s) | DNA [cytosine-5]-methyltransferase 3A (DNMT3A) | Target Info | PPI Info | [3] | |
| DNA [cytosine-5]-methyltransferase 3-like (DNMT3L) | Target Info | PPI Info | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun. 2004 May 28;318(2):544-55. | ||||
| REF 2 | Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol. 2003 Jul 15;13(14):1192-200. | ||||
| REF 3 | Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 2004 Jan 29;32(2):598-610. | ||||
| REF 4 | Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002 Apr;129(8):1983-93. | ||||
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