Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T29355 Target Info
Target Name DNA [cytosine-5]-methyltransferase 3A (DNMT3A)
Synonyms M.HsaIIIA; Dnmt3a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNA (cytosine-5)-methyltransferase 3A
Target Type Patented-recorded Target
Gene Name DNMT3A
Biochemical Class Methyltransferase
UniProt ID
DNM3A_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase UHRF1 (UHRF1) Interacting Protein Interacting Protein Info
UniProt ID
UHRF1_HUMAN 
Synonyms ICBP90; Np95; RNF106; hNP95; hUHRF1; huNp95
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [4]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 3B (DNMT3B) Clinical trial Target Interacting Protein Info
UniProt ID
DNM3B_HUMAN 
Synonyms M.HsaIIIB; Dnmt3b; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA methyltransferase 3B; DNA (cytosine-5)-methyltransferase 3B
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [9]
5 Reconstituted Complex [9]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [10]
Other proteins [+] 1 Other proteins +
Interacting Target Name DNA [cytosine-5]-methyltransferase 3-like (DNMT3L) Patented-recorded Target Interacting Protein Info
UniProt ID
DNM3L_HUMAN 
Synonyms DNA (cytosine-5)-methyltransferase 3-like
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-localization [12]
3 Reconstituted Complex [13]
4 Yeast two hybrid [14]
References  Top
REF 1 Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep. 2009 Nov;10(11):1259-64.
REF 2 S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance. Cell Res. 2011 Dec;21(12):1723-39.
REF 3 The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res. 2011 Oct;39(19):8355-65.
REF 4 Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J. 2001 May 15;20(10):2536-44.
REF 5 Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics. 2009 Oct 1;4(7):487-99.
REF 6 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 7 Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 2004 Jan 29;32(2):598-610.
REF 8 Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol. 2003 Jul 15;13(14):1192-200.
REF 9 Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J. 2002 Aug 1;21(15):4183-95.
REF 10 Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005 Jan 26;24(2):336-46.
REF 11 Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002 Apr;129(8):1983-93.
REF 12 DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFB complex in the (de-)methylation of TRAF1. Biochimie. 2014 Sep;104:36-49.
REF 13 DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 2007 Aug 9;448(7154):714-7.
REF 14 Interactions within the mammalian DNA methyltransferase family. BMC Mol Biol. 2003 May 30;4:7.

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