Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T05090 Target Info
Target Name Histone deacetylase 3 (HDAC3)
Synonyms SMAP45; RPD32; RPD3-2; HD3
Target Type Clinical trial Target
Gene Name HDAC3
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
HDAC3_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name F-box-like/WD repeat-containing protein TBL1X (TBL1X) Interacting Protein Interacting Protein Info
UniProt ID
TBL1X_HUMAN 
Synonyms EBI; SMAP55; TBL1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [5]
6 Reconstituted Complex [7]
Interacting Target Name Transducin beta-like 1X-related protein 1 (TBL1XR1) Literature-reported Target Interacting Protein Info
UniProt ID
TBL1R_HUMAN 
Synonyms Transducin betalike 1Xrelated protein 1; TBLR1; TBL1-related protein 1; TBL1related protein 1; Nuclear receptor corepressor/HDAC3 complexsubunit TBLR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; IRA1; F-box-like/WD repeat-containing protein TBL1XR1; Fboxlike/WD repeatcontaining protein TBL1XR1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [8]
Carbon-nitrogen hydrolases [+] 4 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 4 (HDAC4) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC4_HUMAN 
Synonyms KIAA0288; HD4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
3 Co-fractionation [11]
4 Reconstituted Complex [11]
Interacting Target Name Histone deacetylase 7 (HDAC7) Patented-recorded Target Interacting Protein Info
UniProt ID
HDAC7_HUMAN 
Synonyms Histone deacetylase 7A; HDAC7A; HD7a; HD7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [12]
Interacting Target Name Histone deacetylase 5 (HDAC5) Patented-recorded Target Interacting Protein Info
UniProt ID
HDAC5_HUMAN 
Synonyms KIAA0600; HD5; Antigen NY-CO-9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [10]
Interacting Target Name Histone deacetylase 9 (HDAC9) Patented-recorded Target Interacting Protein Info
UniProt ID
HDAC9_HUMAN 
Synonyms MITR; MEF2-interacting transcription repressor MITR; KIAA0744; Histone deacetylase-related protein; Histone deacetylase 7B; HDRP; HDAC7B; HDAC7; HD9; HD7b
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [15]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Co-localization [17]
Kinases [+] 2 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Affinity Capture-Western [19]
3 Co-purification [19]
4 Reconstituted Complex [19]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Biochemical Activity [20]
Nuclear hormone receptors [+] 7 Nuclear hormone receptors +
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Affinity Capture-Western [22]
3 Affinity Capture-Western [23]
4 Biochemical Activity [23]
5 Co-localization [22]
Interacting Protein Name Nuclear receptor subfamily 2 group C member 1 (NR2C1) Interacting Protein Interacting Protein Info
UniProt ID
NR2C1_HUMAN 
Synonyms TR2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Affinity Capture-Western [25]
3 Yeast two hybrid [24]
4 Yeast two hybrid [26]
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [27]
2 Affinity Capture-Western [8]
3 Reconstituted Complex [28]
Interacting Target Name Thyroid hormone receptor alpha (THRA) Successful Target Interacting Protein Info
UniProt ID
THA_HUMAN 
Synonyms V-erbA-related protein 7; THRA2; THRA1; Nuclear receptor subfamily 1 group A member 1; NR1A1; ERBA1; EAR-7; EAR7; C-erbA-alpha; C-erbA-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Affinity Capture-Western [30]
3 Reconstituted Complex [29]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [31]
Interacting Target Name Peroxisome proliferator-activated receptor delta (PPARD) Clinical trial Target Interacting Protein Info
UniProt ID
PPARD_HUMAN 
Synonyms PPAR-delta; PPARdelta; PPAR-beta; PPARB; Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Reconstituted Complex [31]
Interacting Target Name Orphan nuclear receptor SHP (NR0B2) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B2_HUMAN 
Synonyms Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Reconstituted Complex [34]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Lysine-specific histone demethylase 1 (LSD) Clinical trial Target Interacting Protein Info
UniProt ID
KDM1A_HUMAN 
Synonyms Lysine-specific histone demethylase 1A; Lysinespecific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; Flavincontaining amine oxidase domaincontaining protein 2; BRAF35-HDAC complex protein BHC110; BRAF35HDAC complex protein BHC110; AOF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ataxin-3 (ATXN3) Interacting Protein Interacting Protein Info
UniProt ID
ATX3_HUMAN 
Synonyms AT3; ATX3; JOS; MJD; MJD1; SCA3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Affinity Capture-Western [36]
3 Reconstituted Complex [35]
Transcription regulators [+] 9 Transcription regulators +
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-MS [37]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [38]
5 Affinity Capture-Western [11]
6 Affinity Capture-Western [19]
7 Affinity Capture-Western [39]
8 Affinity Capture-Western [40]
9 Affinity Capture-Western [6]
10 Affinity Capture-Western [41]
11 Affinity Capture-Western [42]
12 Affinity Capture-Western [43]
13 Affinity Capture-Western [44]
14 Reconstituted Complex [39]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-MS [37]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [38]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [11]
7 Affinity Capture-Western [5]
8 Affinity Capture-Western [19]
9 Affinity Capture-Western [40]
10 Co-localization [45]
11 Reconstituted Complex [40]
12 Reconstituted Complex [37]
13 Yeast two hybrid [40]
14 Yeast two hybrid [46]
Interacting Protein Name G protein pathway suppressor 2 (GPS2) Interacting Protein Interacting Protein Info
UniProt ID
GPS2_HUMAN 
Synonyms AMF.1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [5]
Interacting Protein Name General transcription factor II-I (GTF2I) Interacting Protein Interacting Protein Info
UniProt ID
GTF2I_HUMAN 
Synonyms BAP135; BTKAP1; DIWS; GTFII.I; IB291; SPIN; TFII.I; WBS; WBSCR6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [47]
2 Affinity Capture-Western [48]
3 Affinity Capture-Western [49]
4 Reconstituted Complex [47]
Interacting Protein Name Transcriptional repressor protein YY1 (YY1) Interacting Protein Interacting Protein Info
UniProt ID
TYY1_HUMAN 
Synonyms DELTA; INO80S; NF.E1; UCRBP; YIN.YANG.1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Affinity Capture-Western [51]
3 Affinity Capture-Western [52]
4 Reconstituted Complex [53]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Reconstituted Complex [54]
3 Reconstituted Complex [55]
Interacting Target Name GATA-binding factor 3 (GATA3) Literature-reported Target Interacting Protein Info
UniProt ID
GATA3_HUMAN 
Synonyms Trans-acting T-cell-specific transcription factor GATA-3; GATA-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [56]
2 Reconstituted Complex [57]
Interacting Target Name Runt-related transcription factor 2 (RUNX2) Literature-reported Target Interacting Protein Info
UniProt ID
RUNX2_HUMAN 
Synonyms SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha Asubunit; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2-alpha A; PEBP2A; PEA2-alpha A; Osteoblast-specific transcription factor 2; OSF-2; OSF2; Oncogene AML-3; Core-binding factor subunit alpha-1; CBF-alpha-1; CBFA1; AML3; Acute myeloid leukemia 3 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [58]
2 Reconstituted Complex [59]
Interacting Target Name Transcription factor SOX-2 (SOX2) Literature-reported Target Interacting Protein Info
UniProt ID
SOX2_HUMAN 
Synonyms ANOP3; MCOPS3; SRY-box 2
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [60]
Other proteins [+] 3 Other proteins +
Interacting Protein Name T-complex protein 1 subunit alpha (TCP1) Interacting Protein Interacting Protein Info
UniProt ID
TCPA_HUMAN 
Synonyms CCT.alpha; CCT1; CCTa; D6S230E; TCP.1.alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [39]
3 Reconstituted Complex [39]
Interacting Protein Name Ankyrin repeat domain-containing protein 11 (ANKRD11) Interacting Protein Interacting Protein Info
UniProt ID
ANR11_HUMAN 
Synonyms ANCO.1; ANCO1; LZ16; T13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [61]
Interacting Protein Name T-complex protein 1 subunit epsilon (CCT5) Interacting Protein Interacting Protein Info
UniProt ID
TCPE_HUMAN 
Synonyms CCT.epsilon; CCTE; HEL.S.69; TCP.1.epsilon
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [39]
References  Top
REF 1 Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol. 2007 Feb;27(4):1280-95.
REF 2 p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc. Oncogene. 2008 Sep 25;27(43):5717-28.
REF 3 Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65.
REF 4 The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol. 2013;9:672.
REF 5 The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell. 2002 Mar;9(3):611-23.
REF 6 A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev. 2000 May 1;14(9):1048-57.
REF 7 Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3243-E3250.
REF 8 Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell. 2006 Feb 10;124(3):615-29.
REF 9 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 10 Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7835-40.
REF 11 Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell. 2002 Jan;9(1):45-57.
REF 12 Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem. 2001 Sep 21;276(38):35826-35.
REF 13 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Mol Cell Proteomics. 2011 Feb;10(2):M110.004317.
REF 14 Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1056-61.
REF 15 The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem. 2003 May 2;278(18):16059-72.
REF 16 A central domain of cyclin D1 mediates nuclear receptor corepressor activity. Oncogene. 2005 Jan 13;24(3):431-44.
REF 17 Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem. 2005 Apr 29;280(17):16934-41.
REF 18 Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation. 2010 Jan 5;121(1):132-42.
REF 19 Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer. EMBO Mol Med. 2018 Apr;10(4). pii: e8478.
REF 20 Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src. Oncogene. 2006 Jul 27;25(32):4495-500.
REF 21 The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell. 2002 Dec;3(6):903-10.
REF 22 Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Mol Cell Biol. 2006 Oct;26(20):7561-74.
REF 23 Inhibition of HDAC3 promotes ligand-independent PPAR activation by protein acetylation. J Mol Endocrinol. 2014 Oct;53(2):191-200.
REF 24 The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. Mol Endocrinol. 2001 Aug;15(8):1318-28.
REF 25 Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic -type globin promoters in differentiated adult erythroid cells. Mol Cell Biol. 2011 Aug;31(16):3298-311.
REF 26 HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. PLoS One. 2009;4(2):e4363.
REF 27 The Dual Estrogen Receptor Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol. 2016 Jan;89(1):14-26.
REF 28 Proteomics analysis of the estrogen receptor alpha receptosome. Mol Cell Proteomics. 2010 Jul;9(7):1411-22.
REF 29 Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity. J Biol Chem. 2007 Mar 30;282(13):9312-22.
REF 30 In vivo repression of an erythroid-specific gene by distinct corepressor complexes. EMBO J. 2002 Mar 15;21(6):1389-97.
REF 31 Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):1-12.
REF 32 The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2613-8.
REF 33 Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15665-70.
REF 34 SHP represses transcriptional activity via recruitment of histone deacetylases. Biochemistry. 2005 Apr 26;44(16):6312-20.
REF 35 Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. J Neurosci. 2006 Nov 1;26(44):11474-86.
REF 36 ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3. J Immunol. 2018 Jul 15;201(2):675-687.
REF 37 The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7202-7.
REF 38 Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 2003 Mar 17;22(6):1336-46.
REF 39 Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev. 2002 Dec 15;16(24):3130-5.
REF 40 Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 2000 Aug 15;19(16):4342-50.
REF 41 A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13074-9.
REF 42 Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer. 2011 May 30;10:68.
REF 43 Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1. FEBS Lett. 2006 Dec 11;580(28-29):6701-6.
REF 44 Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program. Sci Rep. 2016 Jan 5;6:18778.
REF 45 Recruitment of distinct chromatin-modifying complexes by tamoxifen-complexed estrogen receptor at natural target gene promoters in vivo. J Biol Chem. 2004 Apr 9;279(15):15050-8.
REF 46 Scaffold attachment factor SAFB1 suppresses estrogen receptor alpha-mediated transcription in part via interaction with nuclear receptor corepressor. Mol Endocrinol. 2006 Feb;20(2):311-20.
REF 47 Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I. J Biol Chem. 2003 Jan 17;278(3):1841-7.
REF 48 Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12807-12.
REF 49 Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor. FEBS J. 2007 Dec;274(23):6065-73.
REF 50 Yin Yang 1 is a critical repressor of matrix metalloproteinase-9 expression in brain neurons. J Biol Chem. 2008 Dec 12;283(50):35140-53.
REF 51 YY1 restrained cell senescence through repressing the transcription of p16. Biochim Biophys Acta. 2008 Oct;1783(10):1876-83.
REF 52 Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. J Biol Chem. 2007 Dec 7;282(49):35457-70.
REF 53 Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem. 1997 Oct 31;272(44):28001-7.
REF 54 Regulation of the HIF-1alpha stability by histone deacetylases. Oncol Rep. 2007 Mar;17(3):647-51.
REF 55 FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001 Oct 15;15(20):2675-86.
REF 56 Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16894-9.
REF 57 GATA3 acetylation at K119 by CBP inhibits cell migration and invasion in lung adenocarcinoma. Biochem Biophys Res Commun. 2018 Mar 4;497(2):633-638.
REF 58 Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells. Gene. 2008 Apr 30;413(1-2):8-17.
REF 59 Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem. 2004 Oct 1;279(40):41998-2007.
REF 60 Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet. 2011 Jun;43(6):607-11.
REF 61 Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators. J Biol Chem. 2004 Aug 6;279(32):33799-805.

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