Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Beta-arrestin-2 (ARRB2) | Literature-reported | Target Info | ||
| UniProt ID | ARRB2_HUMAN | ||||
| Gene Name | ARRB2 | ||||
| Gene ID | 409 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
| Adrenergic receptor beta-2 (ADRB2) | Target Info | PPI Info | [2] | ||
| RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [3] | ||
| Interacting Clinical trial Target(s) | Extracellular signal-regulated kinase 2 (ERK2) | Target Info | PPI Info | [4] | |
| Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [5] | ||
| MAPK/ERK kinase kinase 1 (MAP3K1) | Target Info | PPI Info | [4] | ||
| Filamin A (FLNA) | Target Info | PPI Info | [4] | ||
| Interacting Patented-recorded Target(s) | Stress-activated protein kinase JNK3 (JNK3) | Target Info | PPI Info | [6] | |
| VHL-interacting deubiquitinating enzyme 1 (VDU1) | Target Info | PPI Info | [7] | ||
| Polyubiquitin-C (UBC) | Target Info | PPI Info | [4] | ||
| Interacting Literature-reported Target(s) | Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) | Target Info | PPI Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
| REF 2 | CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human adrenergic receptor. Biochem Biophys Res Commun. 2014 Mar 21;445(4):746-56. | ||||
| REF 3 | c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. PLoS One. 2009;4(3):e4686. | ||||
| REF 4 | Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6. | ||||
| REF 5 | Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem. 2003 Feb 21;278(8):6363-70. | ||||
| REF 6 | Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. J Biol Chem. 2001 Jul 27;276(30):27770-7. | ||||
| REF 7 | Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6650-5. | ||||
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