Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T52522 Target Info
Target Name Adrenergic receptor beta-2 (ADRB2)
Synonyms Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R
Target Type Successful Target
Gene Name ADRB2
Biochemical Class GPCR rhodopsin
UniProt ID
ADRB2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Arrestin domain-containing protein 3 (ARRDC3) Interacting Protein Interacting Protein Info
UniProt ID
ARRD3_HUMAN 
Synonyms TLIMP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Fluorescence Resonance Energy Transfer [4]
3 Reconstituted Complex [4]
Auxiliary transporters [+] 3 Auxiliary transporters +
Interacting Target Name Receptor of activated protein C kinase 1 (RACK1) Literature-reported Target Interacting Protein Info
UniProt ID
RACK1_HUMAN 
Synonyms Small ribosomal subunit protein RACK1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor for activated C kinase; Human lung cancer oncogene 7 protein; HLC-7; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-2-like 1; GNB2L1; Cell proliferation-inducing gene 21 protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [5]
4 Protein-Fragment Complementation Assay [5]
Interacting Protein Name G protein subunit beta 1 (GNB1) Interacting Protein Interacting Protein Info
UniProt ID
GBB1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Fluorescence Resonance Energy Transfer [6]
Interacting Protein Name SRY-interacting protein 1 (SLC9A3R2) Interacting Protein Interacting Protein Info
UniProt ID
NHRF2_HUMAN 
Synonyms E3KARP; NHE3RF2; NHERF.2; NHERF2; OCTS2; SIP.1; SIP1; TKA.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [7]
Beta-barrel porins [+] 1 Beta-barrel porins +
Interacting Target Name Voltage-dependent anion-selective channel 2 (VDAC2) Literature-reported Target Interacting Protein Info
UniProt ID
VDAC2_HUMAN 
Synonyms VDAC-2; VDAC2; Outer mitochondrial membrane protein porin 2; hVDAC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-Fragment Complementation Assay [5]
Kinases [+] 2 Kinases +
Interacting Protein Name G protein-coupled receptor kinase 6 (GRK6) Interacting Protein Interacting Protein Info
UniProt ID
GRK6_HUMAN 
Synonyms GPRK6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Protein-Fragment Complementation Assay [5]
3 Reconstituted Complex [8]
Interacting Target Name Beta-adrenergic receptor kinase 1 (ADRBK1) Patented-recorded Target Interacting Protein Info
UniProt ID
ARBK1_HUMAN 
Synonyms GRK2; G-protein coupled receptor kinase 2; Beta-ARK-1; BetaARK1; Beta ARK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [8]
Nuclear RNA exporters [+] 1 Nuclear RNA exporters +
Interacting Protein Name GTP-binding nuclear protein Ran (RAN) Interacting Protein Interacting Protein Info
UniProt ID
RAN_HUMAN 
Synonyms ARA24; Gsp1; TC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-Fragment Complementation Assay [5]
Other proteins [+] 3 Other proteins +
Interacting Protein Name A-kinase anchor protein 12 (AKAP12) Interacting Protein Interacting Protein Info
UniProt ID
AKA12_HUMAN 
Synonyms AKAP250; SSeCKS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Co-fractionation [10]
3 Reconstituted Complex [9]
Interacting Protein Name Neuroendocrine secretory protein 55 (GNAS) Interacting Protein Interacting Protein Info
UniProt ID
GNAS3_HUMAN 
Synonyms AHO; C20orf45; GNAS1; GPSA; GSA; GSP; NESP; PHP1A; PHP1B; PHP1C; POH
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [11]
3 Fluorescence Resonance Energy Transfer [6]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Fluorescence Resonance Energy Transfer [4]
References  Top
REF 1 Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Mol Endocrinol. 2013 Aug;27(8):1245-66.
REF 2 VCP/p97 regulates 2AR quality control during receptor biosynthesis. Cell Signal. 2017 Jan;30:50-58.
REF 3 Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor. EMBO Rep. 2010 Aug;11(8):605-11.
REF 4 The -Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the 2-Adrenergic Receptor. J Biol Chem. 2016 Jul 8;291(28):14510-25.
REF 5 CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human adrenergic receptor. Biochem Biophys Res Commun. 2014 Mar 21;445(4):746-56.
REF 6 Real-time monitoring of receptor and G-protein interactions in living cells. Nat Methods. 2005 Mar;2(3):177-84.
REF 7 A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8496-501.
REF 8 Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. Biochemistry. 1996 Apr 2;35(13):4155-60.
REF 9 The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic... J Biol Chem. 2001 Jun 29;276(26):24005-14.
REF 10 Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin. J Biol Chem. 1999 Jan 15;274(3):1588-95.
REF 11 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. J Biol Chem. 2002 Aug 9;277(32):28631-40.

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