Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T90167 Target Info
Target Name Polyubiquitin-C (UBC)
Synonyms ubiquitin C; HMG20
Target Type Patented-recorded Target
Gene Name UBC
UniProt ID
UBC_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 8 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [4]
Interacting Protein Name ATPase WRNIP1 (WRNIP1) Interacting Protein Interacting Protein Info
UniProt ID
WRIP1_HUMAN 
Synonyms WHIP; bA420G6.2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [5]
4 Reconstituted Complex [4]
Interacting Protein Name Unconventional myosin-VI (MYO6) Interacting Protein Interacting Protein Info
UniProt ID
MYO6_HUMAN 
Synonyms DFNA22; DFNB37
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit ATPase 5 (PSMC5) Interacting Protein Interacting Protein Info
UniProt ID
PRS8_HUMAN 
Synonyms S8; SUG.1; SUG1; TBP10; TRIP1; p45; p45/SUG
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [6]
3 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit ATPase 6 (PSMC6) Interacting Protein Interacting Protein Info
UniProt ID
PRS10_HUMAN 
Synonyms CADP44; HEL.S.73; P44; SUG2; p42
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit ATPase 1 (PSMC1) Interacting Protein Interacting Protein Info
UniProt ID
PRS4_HUMAN 
Synonyms P26S4; S4; p56
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit ATPase 3 (PSMC3) Interacting Protein Interacting Protein Info
UniProt ID
PRS6A_HUMAN 
Synonyms TBP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit ATPase 4 (PSMC4) Interacting Protein Interacting Protein Info
UniProt ID
PRS6B_HUMAN 
Synonyms MIP224; RPT3; S6; TBP.7; TBP7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Acyltransferases [+] 24 Acyltransferases +
Interacting Protein Name UV excision repair protein RAD23 homolog A (RAD23A) Interacting Protein Interacting Protein Info
UniProt ID
RD23A_HUMAN 
Synonyms HHR23A; HR23A
Evidence Score (E-score) 6 Experimental Evidences +
1 Protein-peptide [7]
2 Reconstituted Complex [8]
3 Reconstituted Complex [5]
4 Reconstituted Complex [4]
5 Reconstituted Complex [9]
6 Reconstituted Complex [10]
Interacting Target Name Linear ubiquitin chain assembly complex (RBCK1) Literature-reported Target Interacting Protein Info
UniProt ID
HOIL1_HUMAN 
Synonyms XAP4; XAP3; Ubiquitin-conjugating enzyme 7-interacting protein 3; UBCE7IP3; RNF54; RING-type E3 ubiquitin transferase HOIL-1; RING finger protein 54; RanBP-type and C3HC4-type zinc finger-containing protein 1; HOIL-1; Hepatitis B virus X-associated protein 4; Heme-oxidized IRP2 ubiquitin ligase 1; HBV-associated factor 4; C20orf18
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [12]
3 Co-crystal Structure [13]
4 Reconstituted Complex [14]
5 Reconstituted Complex [4]
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Biochemical Activity [16]
3 Co-crystal Structure [17]
4 Reconstituted Complex [17]
Interacting Protein Name E3 ubiquitin-protein ligase parkin (PRKN) Interacting Protein Interacting Protein Info
UniProt ID
PRKN_HUMAN 
Synonyms AR.JP; LPRS2; PDJ; PRKN
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Co-localization [18]
3 Reconstituted Complex [19]
4 Reconstituted Complex [18]
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [20]
2 Co-crystal Structure [21]
3 Reconstituted Complex [22]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [24]
3 Biochemical Activity [25]
Interacting Protein Name E3 ubiquitin-protein ligase HUWE1 (HUWE1) Interacting Protein Interacting Protein Info
UniProt ID
HUWE1_HUMAN 
Synonyms ARF.BP1; HECTH9; HSPC272; Ib772; LASU1; MULE; URE.B1; UREB1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [5]
3 Reconstituted Complex [4]
Interacting Protein Name E3 ubiquitin-protein ligase RAD18 (RAD18) Interacting Protein Interacting Protein Info
UniProt ID
RAD18_HUMAN 
Synonyms RNF73
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [9]
3 Reconstituted Complex [26]
Interacting Protein Name UV excision repair protein RAD23 homolog B (RAD23B) Interacting Protein Interacting Protein Info
UniProt ID
RD23B_HUMAN 
Synonyms HHR23B; HR23B; P58
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
3 Reconstituted Complex [4]
Interacting Protein Name E3 ubiquitin-protein ligase RNF114 (RNF114) Interacting Protein Interacting Protein Info
UniProt ID
RN114_HUMAN 
Synonyms PSORS12; ZNF313
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [9]
Interacting Protein Name E3 ubiquitin-protein ligase UBR4 (UBR4) Interacting Protein Interacting Protein Info
UniProt ID
UBR4_HUMAN 
Synonyms RBAF600; ZUBR1; p600
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [5]
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [27]
2 Reconstituted Complex [28]
Interacting Target Name Cellular inhibitor of apoptosis 2 (BIRC3) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC3_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 1; TNFR2TRAFsignaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; hIAP-1; hIAP1; C-IAP2; CIAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [27]
2 Reconstituted Complex [28]
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [29]
2 Reconstituted Complex [28]
Interacting Target Name ATP-citrate synthase (ACLY) Successful Target Interacting Protein Info
UniProt ID
ACLY_HUMAN 
Synonyms Citrate cleavageenzyme; Citrate cleavage enzyme; ATP-citrate lyase; ATP-citrate (pro-S-)-lyase; Acly; ACL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [5]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [31]
Interacting Target Name E3 ubiquitin protein ligase Itchy (ITCH) Literature-reported Target Interacting Protein Info
UniProt ID
ITCH_HUMAN 
Synonyms NFE2-associated polypeptide 1; NAPP1; Itch; HECT-type E3 ubiquitin transferase Itchy homolog; E3 ubiquitin-protein ligase Itchy homolog; Atrophin-1-interacting protein 4; AIP4
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [32]
2 Protein-peptide [33]
Interacting Protein Name E3 ubiquitin-protein ligase AMFR (AMFR) Interacting Protein Interacting Protein Info
UniProt ID
AMFR_HUMAN 
Synonyms GP78; RNF45
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Reconstituted Complex [35]
Interacting Protein Name BRCA1-associated protein (BRAP) Interacting Protein Interacting Protein Info
UniProt ID
BRAP_HUMAN 
Synonyms BRAP2; IMP; RNF52
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name E3 ubiquitin-protein ligase HERC2 (HERC2) Interacting Protein Interacting Protein Info
UniProt ID
HERC2_HUMAN 
Synonyms D15F37S1; MRT38; SHEP1; jdf2; p528
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Reconstituted Complex [4]
Interacting Protein Name E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) Interacting Protein Interacting Protein Info
UniProt ID
NED4L_HUMAN 
Synonyms NEDD4.2; NEDD4.2; RSP5; hNEDD4.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [37]
2 Reconstituted Complex [38]
Interacting Protein Name E3 ubiquitin-protein ligase RNF126 (RNF126) Interacting Protein Interacting Protein Info
UniProt ID
RN126_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [39]
Interacting Protein Name E3 ubiquitin-protein ligase RNF31 (RNF31) Interacting Protein Interacting Protein Info
UniProt ID
RNF31_HUMAN 
Synonyms HOIP; ZIBRA
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [14]
2 Reconstituted Complex [4]
Interacting Protein Name E3 SUMO-protein ligase ZNF451 (ZNF451) Interacting Protein Interacting Protein Info
UniProt ID
ZN451_HUMAN 
Synonyms COASTER; dJ417I1.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [40]
2 Reconstituted Complex [4]
Adapter proteins [+] 5 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [41]
3 Co-crystal Structure [42]
4 Co-localization [43]
5 Protein-peptide [41]
6 Protein-peptide [42]
7 Reconstituted Complex [9]
8 Reconstituted Complex [44]
9 Reconstituted Complex [45]
10 Reconstituted Complex [46]
11 Reconstituted Complex [5]
12 Reconstituted Complex [4]
13 Reconstituted Complex [47]
14 Reconstituted Complex [48]
15 Yeast two hybrid [48]
Interacting Protein Name SH3 domain-containing kinase-binding protein 1 (SH3KBP1) Interacting Protein Interacting Protein Info
UniProt ID
SH3K1_HUMAN 
Synonyms CD2BP3; CIN85; GIG10; HSB.1; HSB1; MIG18
Evidence Score (E-score) 5 Experimental Evidences +
1 Co-crystal Structure [49]
2 Co-crystal Structure [50]
3 Reconstituted Complex [50]
4 Reconstituted Complex [49]
5 Reconstituted Complex [51]
Interacting Protein Name Signal transducing adapter molecule 1 (STAM) Interacting Protein Interacting Protein Info
UniProt ID
STAM1_HUMAN 
Synonyms STAM.1; STAM1
Evidence Score (E-score) 5 Experimental Evidences +
1 Co-crystal Structure [52]
2 Reconstituted Complex [5]
3 Reconstituted Complex [53]
4 Reconstituted Complex [4]
5 Reconstituted Complex [54]
Interacting Protein Name Signal transducing adapter molecule 2 (STAM2) Interacting Protein Interacting Protein Info
UniProt ID
STAM2_HUMAN 
Synonyms Hbp; STAM2A; STAM2B
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [54]
2 Reconstituted Complex [4]
Interacting Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) Interacting Protein Interacting Protein Info
UniProt ID
TAB2_HUMAN 
Synonyms CHTD2; MAP3K7IP2; TAB.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [10]
2 Reconstituted Complex [4]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Syntenin-1 (SDCBP) Interacting Protein Interacting Protein Info
UniProt ID
SDCB1_HUMAN 
Synonyms MDA.9; MDA9; ST1; SYCL; TACIP18
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 6 (HDAC6) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC6_HUMAN 
Synonyms KIAA0901; JM21; HD6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [55]
2 Reconstituted Complex [56]
3 Reconstituted Complex [57]
4 Reconstituted Complex [4]
Cullins [+] 1 Cullins +
Interacting Target Name Cullin-3 (CUL-3) Literature-reported Target Interacting Protein Info
UniProt ID
CUL3_HUMAN 
Synonyms KIAA0617; Cullin3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [58]
2 Biochemical Activity [59]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Protein Name Mitochondrial deadenylase (PDE12) Interacting Protein Interacting Protein Info
UniProt ID
PDE12_HUMAN 
Synonyms 2.PDE
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
3 Reconstituted Complex [4]
Interacting Protein Name Protein argonaute-2 (AGO2) Interacting Protein Interacting Protein Info
UniProt ID
AGO2_HUMAN 
Synonyms EIF2C2; Q10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
FAM proteins [+] 2 FAM proteins +
Interacting Protein Name BRCA1-A complex subunit Abraxas 1 (ABRAXAS1) Interacting Protein Interacting Protein Info
UniProt ID
ABRX1_HUMAN 
Synonyms ABRA1; CCDC98
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [60]
3 Reconstituted Complex [4]
Interacting Protein Name BRISC complex subunit Abraxas 2 (ABRAXAS2) Interacting Protein Interacting Protein Info
UniProt ID
ABRX2_HUMAN 
Synonyms ABRO1; KIAA0157
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [60]
2 Reconstituted Complex [5]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Protein Name Nuclear protein localization protein 4 homolog (NPLOC4) Interacting Protein Interacting Protein Info
UniProt ID
NPL4_HUMAN 
Synonyms NPL4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [10]
4 Reconstituted Complex [4]
Kinases [+] 5 Kinases +
Interacting Protein Name Serine/threonine-protein kinase RIO3 (RIOK3) Interacting Protein Interacting Protein Info
UniProt ID
RIOK3_HUMAN 
Synonyms SUDD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [9]
4 Reconstituted Complex [4]
Interacting Protein Name DNA polymerase eta (POLH) Interacting Protein Interacting Protein Info
UniProt ID
POLH_HUMAN 
Synonyms RAD30; RAD30A; XP.V; XPV
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [61]
2 Reconstituted Complex [62]
3 Reconstituted Complex [57]
4 Yeast two hybrid [62]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [63]
2 Affinity Capture-Western [64]
Interacting Protein Name DNA-directed RNA polymerase II subunit RPB3 (POLR2C) Interacting Protein Interacting Protein Info
UniProt ID
RPB3_HUMAN 
Synonyms RPB3; RPB31; hRPB33; hsRPB3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name DNA polymerase iota (POLI) Interacting Protein Interacting Protein Info
UniProt ID
POLI_HUMAN 
Synonyms RAD30B; RAD3OB
Evidence Score (E-score) 2 Experimental Evidences +
1 Far Western [65]
2 Yeast two hybrid [66]
Peptidases [+] 29 Peptidases +
Interacting Target Name Isopeptidase T (USP5) Preclinical Target Interacting Protein Info
UniProt ID
UBP5_HUMAN 
Synonyms Ubiquitin-specific-processing protease 5; Ubiquitin thioesterase 5; Ubiquitin carboxyl-terminal hydrolase 5; ISOT; Deubiquitinating enzyme 5
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [67]
2 Affinity Capture-MS [2]
3 Biochemical Activity [68]
4 Co-crystal Structure [69]
5 Protein-peptide [33]
6 Reconstituted Complex [8]
7 Reconstituted Complex [70]
8 Reconstituted Complex [5]
9 Reconstituted Complex [4]
10 Reconstituted Complex [71]
11 Reconstituted Complex [9]
12 Reconstituted Complex [68]
Interacting Target Name Ubiquitin thioesterase L1 (UCHL1) Preclinical Target Interacting Protein Info
UniProt ID
UCHL1_HUMAN 
Synonyms UCH-L1; Ubiquitin thiolesterase L1; Ubiquitin carboxy-terminal hydrolase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5
Evidence Score (E-score) 7 Experimental Evidences +
1 Biochemical Activity [20]
2 Co-crystal Structure [72]
3 Reconstituted Complex [73]
4 Reconstituted Complex [71]
5 Reconstituted Complex [74]
6 Reconstituted Complex [75]
7 Yeast two hybrid [76]
Interacting Target Name Ubiquitin thioesterase L3 (UCHL3) Literature-reported Target Interacting Protein Info
UniProt ID
UCHL3_HUMAN 
Synonyms UCH-L3; Ubiquitin carboxyl-terminal hydrolase isozyme L3
Evidence Score (E-score) 7 Experimental Evidences +
1 Biochemical Activity [20]
2 Co-crystal Structure [77]
3 Reconstituted Complex [73]
4 Reconstituted Complex [4]
5 Reconstituted Complex [71]
6 Reconstituted Complex [75]
7 Reconstituted Complex [78]
Interacting Target Name Ubiquitin C-terminal hydrolase UCH37 (UCHL5) Patented-recorded Target Interacting Protein Info
UniProt ID
UCHL5_HUMAN 
Synonyms UCH-L5; UCH37; Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; CGI-70; AD-019
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [79]
3 Co-crystal Structure [80]
4 Reconstituted Complex [4]
5 Reconstituted Complex [71]
6 Reconstituted Complex [75]
Interacting Target Name Ubiquitin carboxyl-terminal hydrolase 14 (USP14) Preclinical Target Interacting Protein Info
UniProt ID
UBP14_HUMAN 
Synonyms Ubiquitin-specific-processing protease 14; Ubiquitin thioesterase 14; TGT; Deubiquitinating enzyme 14
Evidence Score (E-score) 5 Experimental Evidences +
1 Biochemical Activity [81]
2 Protein-peptide [33]
3 Reconstituted Complex [73]
4 Reconstituted Complex [4]
5 Reconstituted Complex [71]
Interacting Target Name Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Preclinical Target Interacting Protein Info
UniProt ID
UBP2_HUMAN 
Synonyms UBP41; Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [20]
3 Co-crystal Structure [82]
4 Protein-peptide [33]
5 Reconstituted Complex [71]
Interacting Protein Name Ataxin-3 (ATXN3) Interacting Protein Interacting Protein Info
UniProt ID
ATX3_HUMAN 
Synonyms AT3; ATX3; JOS; MJD; MJD1; SCA3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
3 Reconstituted Complex [4]
4 Reconstituted Complex [83]
5 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin thioesterase ZRANB1 (ZRANB1) Interacting Protein Interacting Protein Info
UniProt ID
ZRAN1_HUMAN 
Synonyms TRABID
Evidence Score (E-score) 5 Experimental Evidences +
1 Co-crystal Structure [10]
2 Co-crystal Structure [84]
3 Reconstituted Complex [10]
4 Reconstituted Complex [4]
5 Reconstituted Complex [84]
Interacting Target Name Herpesvirus ubiquitin-specific protease (HAUSP) Preclinical Target Interacting Protein Info
UniProt ID
UBP7_HUMAN 
Synonyms Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [20]
2 Co-crystal Structure [85]
3 Protein-peptide [33]
4 Reconstituted Complex [86]
Interacting Target Name Ubiquitin carboxyl-terminal hydrolase 37 (USP37) Literature-reported Target Interacting Protein Info
UniProt ID
UBP37_HUMAN 
Synonyms Ubiquitin-specific-processing protease 37; Ubiquitin thioesterase 37; KIAA1594; Deubiquitinating enzyme 37
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [87]
2 Biochemical Activity [87]
3 Protein-peptide [33]
4 Reconstituted Complex [87]
Interacting Protein Name Ubiquitin thioesterase OTUB1 (OTUB1) Interacting Protein Interacting Protein Info
UniProt ID
OTUB1_HUMAN 
Synonyms OTB1; OTU1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [88]
3 Reconstituted Complex [4]
4 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 13 (USP13) Interacting Protein Interacting Protein Info
UniProt ID
UBP13_HUMAN 
Synonyms ISOT3; IsoT.3
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [5]
2 Reconstituted Complex [4]
3 Reconstituted Complex [71]
4 Reconstituted Complex [68]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 25 (USP25) Interacting Protein Interacting Protein Info
UniProt ID
UBP25_HUMAN 
Synonyms USP21
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [5]
2 Reconstituted Complex [4]
3 Reconstituted Complex [71]
4 Reconstituted Complex [89]
Interacting Target Name Ubiquitin thioesterase OTU1 (YOD1) Literature-reported Target Interacting Protein Info
UniProt ID
OTU1_HUMAN 
Synonyms PRO0907; OTUD2; OTU domain-containing protein 2; HsHIN7; HIV-1-induced protease 7; HIN-7; HIN7; DUBA-8; DUBA8
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [90]
2 Co-crystal Structure [90]
3 Reconstituted Complex [91]
Interacting Target Name Ubiquitin isopeptidase Y (USP8) Preclinical Target Interacting Protein Info
UniProt ID
UBP8_HUMAN 
Synonyms UBPY; Ubiquitin-specific-processing protease 8; Ubiquitin thioesterase 8; Ubiquitin carboxyl-terminal hydrolase 8; KIAA0055; hUBPy; Deubiquitinating enzyme 8
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [92]
2 Co-crystal Structure [33]
3 Protein-peptide [33]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 3 (USP3) Interacting Protein Interacting Protein Info
UniProt ID
UBP3_HUMAN 
Synonyms SIH003; UBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [67]
2 Reconstituted Complex [4]
3 Reconstituted Complex [71]
Interacting Protein Name Lys-63-specific deubiquitinase BRCC36 (BRCC3) Interacting Protein Interacting Protein Info
UniProt ID
BRCC3_HUMAN 
Synonyms BRCC36; C6.1A; CXorf53
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [60]
2 Reconstituted Complex [4]
Interacting Protein Name OTU domain-containing protein 4 (OTUD4) Interacting Protein Interacting Protein Info
UniProt ID
OTUD4_HUMAN 
Synonyms DUBA6; HIN1; HSHIN1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Interacting Protein Name OTU domain-containing protein 5 (OTUD5) Interacting Protein Interacting Protein Info
UniProt ID
OTUD5_HUMAN 
Synonyms DUBA
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Interacting Protein Name Proteasome 26S subunit non-ATPase 14 (PSMD14) Interacting Protein Interacting Protein Info
UniProt ID
PSDE_HUMAN 
Synonyms PAD1; POH1; RPN11
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit non-ATPase 7 (PSMD7) Interacting Protein Interacting Protein Info
UniProt ID
PSMD7_HUMAN 
Synonyms MOV34; P40; Rpn8; S12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 11 (USP11) Interacting Protein Interacting Protein Info
UniProt ID
UBP11_HUMAN 
Synonyms UHX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 15 (USP15) Interacting Protein Interacting Protein Info
UniProt ID
UBP15_HUMAN 
Synonyms UNPH.2; UNPH4
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 16 (USP16) Interacting Protein Interacting Protein Info
UniProt ID
UBP16_HUMAN 
Synonyms UBP.M; UBPM
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 19 (USP19) Interacting Protein Interacting Protein Info
UniProt ID
UBP19_HUMAN 
Synonyms ZMYND9
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 24 (USP24) Interacting Protein Interacting Protein Info
UniProt ID
UBP24_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 32 (USP32) Interacting Protein Interacting Protein Info
UniProt ID
UBP32_HUMAN 
Synonyms NY.REN.60; USP10
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 4 (USP4) Interacting Protein Interacting Protein Info
UniProt ID
UBP4_HUMAN 
Synonyms UNP; Unph
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [71]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 40 (USP40) Interacting Protein Interacting Protein Info
UniProt ID
UBP40_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [71]
Phagophore-form transporters [+] 1 Phagophore-form transporters +
Interacting Protein Name Autophagy-related protein 16-1 (ATG16L1) Interacting Protein Interacting Protein Info
UniProt ID
A16L1_HUMAN 
Synonyms APG16L; ATG16A; ATG16L; IBD10; WDR30
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [93]
2 Reconstituted Complex [93]
3 Reconstituted Complex [94]
Proteasome components [+] 6 Proteasome components +
Interacting Protein Name Proteasome 26S subunit non-ATPase 4 (PSMD4) Interacting Protein Interacting Protein Info
UniProt ID
PSMD4_HUMAN 
Synonyms AF; AF.1; ASF; MCB1; Rpn10; S5A; pUB.R5
Evidence Score (E-score) 5 Experimental Evidences +
1 Reconstituted Complex [95]
2 Reconstituted Complex [96]
3 Reconstituted Complex [5]
4 Reconstituted Complex [4]
5 Reconstituted Complex [9]
Interacting Protein Name Proteasomal ubiquitin receptor ADRM1 (ADRM1) Interacting Protein Interacting Protein Info
UniProt ID
ADRM1_HUMAN 
Synonyms ARM.1; ARM1; GP110
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [97]
2 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit non-ATPase 11 (PSMD11) Interacting Protein Interacting Protein Info
UniProt ID
PSD11_HUMAN 
Synonyms Rpn6; S9; p44.5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit non-ATPase 12 (PSMD12) Interacting Protein Interacting Protein Info
UniProt ID
PSD12_HUMAN 
Synonyms Rpn5; p55
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit non-ATPase 5 (PSMD5) Interacting Protein Interacting Protein Info
UniProt ID
PSMD5_HUMAN 
Synonyms S5B
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [98]
2 Reconstituted Complex [4]
Interacting Protein Name Proteasome 26S subunit non-ATPase 8 (PSMD8) Interacting Protein Interacting Protein Info
UniProt ID
PSMD8_HUMAN 
Synonyms HEL.S.91n; HIP6; HYPF; Nin1p; Rpn12; S14; p31
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [99]
2 Yeast two hybrid [100]
Interacting Protein Name TRAF-type zinc finger domain-containing protein 1 (TRAFD1) Interacting Protein Interacting Protein Info
UniProt ID
TRAD1_HUMAN 
Synonyms FLN29
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
Ubiquitin related proteins [+] 15 Ubiquitin related proteins +
Interacting Target Name Tumor susceptibility gene protein 101 (TSG101) Clinical trial Target Interacting Protein Info
UniProt ID
TS101_HUMAN 
Synonyms Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [101]
2 Affinity Capture-Western [64]
3 Co-crystal Structure [102]
4 Reconstituted Complex [64]
5 Reconstituted Complex [53]
6 Reconstituted Complex [4]
Interacting Protein Name Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) Interacting Protein Interacting Protein Info
UniProt ID
UBS3B_HUMAN 
Synonyms STS.1; STS1; TULA.2; TULA2; p70
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [103]
2 Reconstituted Complex [104]
3 Reconstituted Complex [105]
4 Reconstituted Complex [4]
Interacting Target Name Ubiquitin-like protein Nedd8 (NEDD8) Clinical trial Target Interacting Protein Info
UniProt ID
NEDD8_HUMAN 
Synonyms Ubiquitin-like protein Nedd8; Neural precursor cell expressed developmentally down-regulated protein 8; Neddylin; NEDD-8
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-crystal Structure [106]
3 Reconstituted Complex [106]
Interacting Protein Name Ubiquitin-associated protein 1 (UBAP1) Interacting Protein Interacting Protein Info
UniProt ID
UBAP1_HUMAN 
Synonyms NAG20; UAP; UBAP; UBAP.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [107]
3 Reconstituted Complex [4]
Interacting Protein Name BRISC and BRCA1-A complex member 2 (BABAM2) Interacting Protein Interacting Protein Info
UniProt ID
BABA2_HUMAN 
Synonyms BRCC4; BRCC45
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [60]
3 Reconstituted Complex [4]
Interacting Protein Name Ubiquitin-like modifier-activating enzyme 1 (UBA1) Interacting Protein Interacting Protein Info
UniProt ID
UBA1_HUMAN 
Synonyms A1S9; A1S9T; A1ST; AMCX1; CFAP124; GXP1; POC20; SMAX2; UBA1A; UBE1; UBE1X
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [67]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [4]
Interacting Protein Name Ubiquitin recognition factor in ER-associated degradation protein 1 (UFD1) Interacting Protein Interacting Protein Info
UniProt ID
UFD1_HUMAN 
Synonyms UFD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [5]
3 Reconstituted Complex [4]
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [108]
2 Reconstituted Complex [109]
Interacting Target Name E3 ubiquitin protein ligase CBLB (CBLB) Literature-reported Target Interacting Protein Info
UniProt ID
CBLB_HUMAN 
Synonyms Signal transduction protein CBL-B; Signal transduction protein CBLB; SH3-binding protein CBL-B; SH3binding protein CBLB; RNF56; RING-type E3 ubiquitin transferase CBL-B; RING finger protein 56; Nbla00127; E3 ubiquitin-protein ligase CBL-B; E3 ubiquitinprotein ligase CBLB; Casitas B-lineage lymphoma proto-oncogene b; Casitas Blineage lymphoma protooncogene b
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [16]
2 Reconstituted Complex [110]
Interacting Protein Name Ubiquitin-like protein 7 (UBL7) Interacting Protein Interacting Protein Info
UniProt ID
UBL7_HUMAN 
Synonyms BMSC.UbP; TCBA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [4]
Interacting Protein Name Anaphase-promoting complex subunit 7 (ANAPC7) Interacting Protein Interacting Protein Info
UniProt ID
APC7_HUMAN 
Synonyms APC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
Interacting Protein Name BRISC and BRCA1-A complex member 1 (BABAM1) Interacting Protein Interacting Protein Info
UniProt ID
BABA1_HUMAN 
Synonyms C19orf62; MERIT40; NBA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Interacting Protein Interacting Protein Info
UniProt ID
UB2D2_HUMAN 
Synonyms E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Reconstituted Complex [111]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Interacting Protein Interacting Protein Info
UniProt ID
UB2D3_HUMAN 
Synonyms E2(17)KB3; UBC4/5; UBCH5C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name UBX domain-containing protein 1 (UBXN1) Interacting Protein Interacting Protein Info
UniProt ID
UBXN1_HUMAN 
Synonyms 2B28; SAKS1; UBXD10
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [4]
Vesicle fusion pores [+] 1 Vesicle fusion pores +
Interacting Protein Name Rab5 GDP/GTP exchange factor (RABGEF1) Interacting Protein Interacting Protein Info
UniProt ID
RABX5_HUMAN 
Synonyms RABEX5; RAP1; rabex.5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [112]
2 Reconstituted Complex [8]
3 Reconstituted Complex [4]
4 Yeast two hybrid [113]
Other proteins [+] 41 Other proteins +
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Co-crystal Structure [114]
3 Protein-peptide [115]
4 Protein-peptide [114]
5 Reconstituted Complex [116]
6 Reconstituted Complex [117]
7 Reconstituted Complex [118]
8 Reconstituted Complex [119]
9 Reconstituted Complex [4]
10 Reconstituted Complex [9]
11 Reconstituted Complex [115]
12 Reconstituted Complex [120]
13 Reconstituted Complex [121]
14 Yeast two hybrid [122]
Interacting Protein Name Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) Interacting Protein Interacting Protein Info
UniProt ID
HGS_HUMAN 
Synonyms HRS
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [123]
2 Affinity Capture-Western [64]
3 Affinity Capture-Western [124]
4 Reconstituted Complex [5]
5 Reconstituted Complex [105]
6 Reconstituted Complex [125]
7 Reconstituted Complex [53]
8 Reconstituted Complex [4]
9 Reconstituted Complex [124]
10 Reconstituted Complex [54]
11 Yeast two hybrid [123]
Interacting Protein Name BRCA1-A complex subunit RAP80 (UIMC1) Interacting Protein Interacting Protein Info
UniProt ID
UIMC1_HUMAN 
Synonyms RAP80; X2HRIP110
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [126]
2 Co-crystal Structure [127]
3 Protein-peptide [128]
4 Protein-peptide [127]
5 Reconstituted Complex [129]
6 Reconstituted Complex [5]
7 Reconstituted Complex [4]
8 Reconstituted Complex [60]
9 Reconstituted Complex [130]
Interacting Protein Name Optineurin (OPTN) Interacting Protein Interacting Protein Info
UniProt ID
OPTN_HUMAN 
Synonyms ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA.INTP
Evidence Score (E-score) 7 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [4]
3 Reconstituted Complex [120]
4 Reconstituted Complex [131]
5 Reconstituted Complex [132]
6 Reconstituted Complex [133]
7 Yeast two hybrid [122]
Interacting Protein Name ADP-ribosylation factor-binding protein GGA3 (GGA3) Interacting Protein Interacting Protein Info
UniProt ID
GGA3_HUMAN 
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [124]
2 Reconstituted Complex [134]
3 Reconstituted Complex [4]
4 Reconstituted Complex [135]
5 Reconstituted Complex [136]
6 Yeast two hybrid [137]
Interacting Protein Name FAS-associated factor 1 (FAF1) Interacting Protein Interacting Protein Info
UniProt ID
FAF1_HUMAN 
Synonyms HFAF1s; UBXD12; UBXN3A; hFAF1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [138]
2 Protein-peptide [139]
3 Reconstituted Complex [139]
4 Reconstituted Complex [5]
5 Reconstituted Complex [140]
Interacting Protein Name Toll-interacting protein (TOLLIP) Interacting Protein Interacting Protein Info
UniProt ID
TOLIP_HUMAN 
Synonyms IL.1RAcPIP
Evidence Score (E-score) 5 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [5]
3 Reconstituted Complex [4]
4 Reconstituted Complex [47]
5 Reconstituted Complex [141]
Interacting Protein Name Target of Myb protein 1 (TOM1) Interacting Protein Interacting Protein Info
UniProt ID
TOM1_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [5]
4 Reconstituted Complex [4]
5 Reconstituted Complex [142]
Interacting Protein Name Ubiquilin-1 (UBQLN1) Interacting Protein Interacting Protein Info
UniProt ID
UBQL1_HUMAN 
Synonyms DA41; DSK2; PLIC.1; UBQN; XDRP1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [143]
3 Reconstituted Complex [8]
4 Reconstituted Complex [10]
5 Yeast two hybrid [113]
Interacting Protein Name AN1-type zinc finger protein 6 (ZFAND6) Interacting Protein Interacting Protein Info
UniProt ID
ZFAN6_HUMAN 
Synonyms AWP1; ZA20D3; ZFAND5B
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [9]
3 Reconstituted Complex [5]
4 Reconstituted Complex [4]
Interacting Protein Name Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) Interacting Protein Interacting Protein Info
UniProt ID
CACO2_HUMAN 
Synonyms NDP52
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [9]
3 Yeast two hybrid [113]
Interacting Protein Name Epsin-1 (EPN1) Interacting Protein Interacting Protein Info
UniProt ID
EPN1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [5]
3 Reconstituted Complex [4]
Interacting Protein Name Epidermal growth factor receptor substrate 15 (EPS15) Interacting Protein Interacting Protein Info
UniProt ID
EPS15_HUMAN 
Synonyms AF.1P; AF1P; MLLT5
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [144]
2 Reconstituted Complex [105]
3 Reconstituted Complex [4]
Interacting Protein Name NEDD4-binding protein 1 (N4BP1) Interacting Protein Interacting Protein Info
UniProt ID
N4BP1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [9]
3 Reconstituted Complex [4]
Interacting Protein Name Nucleosome assembly protein 1-like 1 (NAP1L1) Interacting Protein Interacting Protein Info
UniProt ID
NP1L1_HUMAN 
Synonyms NAP1; NAP1L; NRP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [2]
Interacting Protein Name PTB-associated-splicing factor (SFPQ) Interacting Protein Interacting Protein Info
UniProt ID
SFPQ_HUMAN 
Synonyms POMP100; PPP1R140; PSF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
3 Yeast two hybrid [76]
Interacting Protein Name TNFAIP3-interacting protein 1 (TNIP1) Interacting Protein Interacting Protein Info
UniProt ID
TNIP1_HUMAN 
Synonyms ABIN.1; NAF1; VAN; nip40.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [122]
2 Reconstituted Complex [9]
3 Reconstituted Complex [4]
Interacting Protein Name TNFAIP3-interacting protein 2 (TNIP2) Interacting Protein Interacting Protein Info
UniProt ID
TNIP2_HUMAN 
Synonyms ABIN2; FLIP1; KLIP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [122]
2 Protein-peptide [115]
3 Reconstituted Complex [9]
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [145]
Interacting Target Name Synuclein alpha (SNCA) Clinical trial Target Interacting Protein Info
UniProt ID
SYUA_HUMAN 
Synonyms PARK1; Non-A4 component of amyloid precursor; NonA4 component of amyloid precursor; Non-A beta component of AD amyloid; NonA beta component of AD amyloid; NACP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [146]
2 Fluorescence Resonance Energy Transfer [147]
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [148]
2 Reconstituted Complex [149]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [150]
2 Fluorescence Resonance Energy Transfer [151]
Interacting Target Name Gankyrin (PSMD10) Literature-reported Target Interacting Protein Info
UniProt ID
PSD10_HUMAN 
Synonyms p28(GANK); 26S proteasome regulatory subunit p28; 26S proteasome non-ATPase regulatory subunit 10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Ankyrin repeat domain-containing protein 13A (ANKRD13A) Interacting Protein Interacting Protein Info
UniProt ID
AN13A_HUMAN 
Synonyms ANKRD13; NY.REN.25
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Coiled-coil domain-containing protein 50 (CCDC50) Interacting Protein Interacting Protein Info
UniProt ID
CCD50_HUMAN 
Synonyms C3orf6; DFNA44; YMER
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [4]
Interacting Protein Name Epsin-2 (EPN2) Interacting Protein Interacting Protein Info
UniProt ID
EPN2_HUMAN 
Synonyms EHB21
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [4]
Interacting Protein Name Exosome complex component RRP43 (EXOSC8) Interacting Protein Interacting Protein Info
UniProt ID
EXOS8_HUMAN 
Synonyms CIP3; EAP2; OIP2; PCH1C; RRP43; Rrp43p; bA421P11.3; p9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
Interacting Protein Name Inhibitor of nuclear factor kappa-B kinase (IKK) Interacting Protein Interacting Protein Info
UniProt ID
Family 
Synonyms IKK; IB kinase; IkappaB kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [152]
2 Reconstituted Complex [153]
Interacting Protein Name Flotillin-1 (FLOT1) Interacting Protein Interacting Protein Info
UniProt ID
FLOT1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [124]
Interacting Protein Name ADP-ribosylation factor-binding protein GGA1 (GGA1) Interacting Protein Interacting Protein Info
UniProt ID
GGA1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [112]
2 Reconstituted Complex [9]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein M (HNRNPM) Interacting Protein Interacting Protein Info
UniProt ID
HNRPM_HUMAN 
Synonyms CEAR; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1; hnRNP M
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
Interacting Protein Name Laminin subunit alpha-1 (LAMA1) Interacting Protein Interacting Protein Info
UniProt ID
LAMA1_HUMAN 
Synonyms LAMA; PTBHS; S.LAM.alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name NSFL1 cofactor p47 (NSFL1C) Interacting Protein Interacting Protein Info
UniProt ID
NSF1C_HUMAN 
Synonyms P47; UBX1; UBXD10; UBXN2C; dJ776F14.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [4]
Interacting Protein Name Polyadenylate-binding protein 4 (PABPC4) Interacting Protein Interacting Protein Info
UniProt ID
PABP4_HUMAN 
Synonyms APP.1; APP1; PABP4; iPABP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein E2 (PCBP2) Interacting Protein Interacting Protein Info
UniProt ID
PCBP2_HUMAN 
Synonyms HNRNPE2; HNRPE2; hnRNP.E2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name SprT-like domain-containing protein Spartan (SPRTN) Interacting Protein Interacting Protein Info
UniProt ID
SPRTN_HUMAN 
Synonyms C1orf124; DDDL1880; DVC1; PRO4323; Spartan; dJ876B10.3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [154]
2 Reconstituted Complex [155]
Interacting Protein Name Tax1-binding protein 1 (TAX1BP1) Interacting Protein Interacting Protein Info
UniProt ID
TAXB1_HUMAN 
Synonyms CALCOCO3; T6BP; TXBP151
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Reconstituted Complex [4]
Interacting Protein Name TBC1 domain family member 15 (TBC1D15) Interacting Protein Interacting Protein Info
UniProt ID
TBC15_HUMAN 
Synonyms RAB7.GAP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name TRPM8 channel-associated factor 1 (TCAF1) Interacting Protein Interacting Protein Info
UniProt ID
TCAF1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Trinucleotide repeat-containing gene 6A protein (TNRC6A) Interacting Protein Interacting Protein Info
UniProt ID
TNR6A_HUMAN 
Synonyms CAGH26; GW1; GW182; TNRC6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [5]
Interacting Protein Name Vacuolar protein sorting-associated protein 28 homolog (VPS28) Interacting Protein Interacting Protein Info
UniProt ID
VPS28_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [64]
2 Reconstituted Complex [4]
References  Top
REF 1 Large-scale analysis of the human ubiquitin-related proteome. Proteomics. 2005 Nov;5(16):4145-51.
REF 2 Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. J Biol Chem. 2007 Aug 10;282(32):23184-93.
REF 3 Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet. 2006 Aug 15;15(16):2409-20.
REF 4 An Interaction Landscape of Ubiquitin Signaling. Mol Cell. 2017 Mar 2;65(5):941-955.e8.
REF 5 Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes EMBO J. 2013 Feb 20;32(4):552-65.
REF 6 The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain. FEBS Lett. 2004 Jan 2;556(1-3):19-25.
REF 7 Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain. Mol Cell. 2005 Jun 10;18(6):687-98.
REF 8 Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry. J Am Chem Soc. 2012 Apr 11;134(14):6416-24.
REF 9 Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochim Biophys Acta. 2009 Jul;1794(7):1010-6.
REF 10 K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin. Mol Cell. 2015 Apr 2;58(1):83-94.
REF 11 Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta. J Biol Chem. 2008 Apr 25;283(17):11575-85.
REF 12 A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J. 2006 Oct 18;25(20):4877-87.
REF 13 Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20520-5.
REF 14 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
REF 15 Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b. Oncogene. 2004 Sep 16;23(42):7104-15.
REF 16 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene. 2004 Mar 4;23(9):1645-55.
REF 17 Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol Cell. 2007 Aug 3;27(3):474-85.
REF 18 Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015 Apr 13;209(1):111-28.
REF 19 Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PLoS Genet. 2014 Dec 4;10(12):e1004861.
REF 20 Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47.
REF 21 Ubiquitin binding to A20 ZnF4 is required for modulation of NF-B signaling. Mol Cell. 2010 Nov 24;40(4):548-57.
REF 22 Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-B regulation. EMBO J. 2012 Oct 3;31(19):3856-70.
REF 23 Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor B (RANK) Signaling Complex Enhances Osteoclastogenesis. J Biol Chem. 2016 Sep 23;291(39):20643-60.
REF 24 p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization. PLoS One. 2013;8(2):e57138.
REF 25 TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004 Aug 27;15(4):535-48.
REF 26 Human KIAA1018/FAN1 localizes to stalled replication forks via its ubiquitin-binding domain. Cell Cycle. 2010 Oct 1;9(19):3977-83.
REF 27 Gliotoxin suppresses NF-B activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). ACS Chem Biol. 2015 Mar 20;10(3):675-81.
REF 28 IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol. 2008 Nov;10(11):1309-17.
REF 29 Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association. PLoS One. 2011;6(12):e28511.
REF 30 An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation. PLoS One. 2012;7(11):e48243.
REF 31 Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation. Nat Struct Mol Biol. 2013 Sep;20(9):1040-6.
REF 32 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics. 2012 Aug;11(8):329-41.
REF 33 A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.
REF 34 The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14422-7.
REF 35 SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Cell Rep. 2012 Dec 27;2(6):1633-44.
REF 36 DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. J Cell Biol. 2012 Apr 16;197(2):179-87.
REF 37 Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol Cell. 2009 Dec 25;36(6):1095-102.
REF 38 Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. J Biol Chem. 2017 Jun 23;292(25):10398-10413.
REF 39 Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation. J Biol Chem. 2018 Jan 12;293(2):588-598.
REF 40 ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. J Mol Biol. 2008 Oct 10;382(3):585-600.
REF 41 Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone. J Bone Miner Res. 2009 Apr;24(4):632-42.
REF 42 Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch. J Biol Chem. 2008 Feb 29;283(9):5427-40.
REF 43 Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2018;14(2):347-358.
REF 44 Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy. Elife. 2015 Sep 28;4:e08941.
REF 45 Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling. J Mol Biol. 2010 Feb 12;396(1):178-94.
REF 46 Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone. Calcif Tissue Int. 2006 May;78(5):271-7.
REF 47 Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family. Cell. 2014 Jul 31;158(3):549-63.
REF 48 p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins. J Biol Chem. 1996 Aug 23;271(34):20235-7.
REF 49 Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications. PLoS One. 2013 Sep 11;8(9):e73018.
REF 50 Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. Biochemistry. 2008 Aug 26;47(34):8937-49.
REF 51 Ubiquitin binds to and regulates a subset of SH3 domains. Mol Cell. 2007 Jan 26;25(2):273-84.
REF 52 Conformational and dynamic changes at the interface contribute to ligand binding by ubiquitin. Biochemistry. 2012 Oct 16;51(41):8111-24.
REF 53 Interplay of Endosomal pH and Ligand Occupancy in Integrin 51Ubiquitination, Endocytic Sorting, and Cell Migration. Cell Rep. 2015 Oct 20;13(3):599-609.
REF 54 PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem. 2010 Jul 30;285(31):23899-907.
REF 55 Development of a histone deacetylase 6 inhibitor and its biological effects. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15704-9.
REF 56 Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis. Mol Cell Biol. 2011 Aug;31(16):3396-409.
REF 57 The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells. Mol Cell. 2010 Jan 15;37(1):79-89.
REF 58 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
REF 59 Suramin inhibits cullin-RING E3 ubiquitin ligases. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8.
REF 60 NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 2009 Mar 15;23(6):729-39.
REF 61 Aberrant C-terminal domain of polymerase targets the functional enzyme to the proteosomal degradation pathway. DNA Repair (Amst). 2015 May;29:154-65.
REF 62 Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science. 2005 Dec 16;310(5755):1821-4.
REF 63 Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics. 2009 Sep;8(9):2131-44.
REF 64 Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol. 2002 Apr 1;157(1):91-101.
REF 65 Ubiquitin mediates the physical and functional interaction between human DNA polymerases and . Nucleic Acids Res. 2013 Feb 1;41(3):1649-60.
REF 66 Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin. EMBO J. 2006 Jun 21;25(12):2847-55.
REF 67 Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol. 2007 Nov 20;17(22):1972-7.
REF 68 Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. PLoS One. 2011;6(12):e29362.
REF 69 The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell. 2006 Mar 24;124(6):1197-208.
REF 70 Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. EMBO Rep. 2012 Oct;13(10):930-8.
REF 71 Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Mol Cell. 2018 Apr 5;70(1):150-164.e6.
REF 72 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9117-22.
REF 73 Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11379-84.
REF 74 Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases. Biochemistry. 1989 Oct 17;28(21):8530-6.
REF 75 Ubiquitin recognition of BAP1: understanding its enzymatic function. Biosci Rep. 2017 Oct 27;37(5). pii: BSR20171099.
REF 76 A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.
REF 77 Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem. 2005 Jan 14;280(2):1512-20.
REF 78 Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol. 2004 Jan;24(1):84-95.
REF 79 Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases. FEBS J. 2012 Mar;279(6):1106-18.
REF 80 Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome. Sci Rep. 2017 Mar 24;7:45174.
REF 81 Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem Biol. 2016 Apr 21;23(4):472-82.
REF 82 Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure. 2006 Aug;14(8):1293-302.
REF 83 Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: removal of the CAG containing exon. Neurobiol Dis. 2013 Oct;58:49-56.
REF 84 Assembly and specific recognition of k29- and k33-linked polyubiquitin. Mol Cell. 2015 Apr 2;58(1):95-109.
REF 85 USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538.
REF 86 USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms. Cell Chem Biol. 2017 Dec 21;24(12):1501-1512.e5.
REF 87 Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP37. J Biol Chem. 2014 Jan 24;289(4):2415-23.
REF 88 Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Sci Signal. 2015 Apr 14;8(372):ra35.
REF 89 Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25. Sci Rep. 2017 Mar 22;7:45037.
REF 90 OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 2013 Jul 3;154(1):169-84.
REF 91 The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell. 2009 Oct 9;36(1):28-38.
REF 92 The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chem Biol. 2011 Dec 23;18(12):1550-61.
REF 93 Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol. 2013 Oct 14;203(1):115-28.
REF 94 Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2. J Biol Chem. 2013 Mar 8;288(10):6890-902.
REF 95 A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat Cell Biol. 2006 Aug;8(8):834-42.
REF 96 The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. J Biol Chem. 2009 May 8;284(19):12622-32.
REF 97 MTMDAT-HADDOCK: high-throughput, protein complex structure modeling based on limited proteolysis and mass spectrometry. BMC Struct Biol. 2012 Nov 15;12:29.
REF 98 Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5. J Biol Chem. 1996 Feb 2;271(5):2823-31.
REF 99 Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14782-7.
REF 100 A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
REF 101 Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions. Mol Cell Proteomics. 2009 Nov;8(11):2474-86.
REF 102 Ubiquitin recognition by the human TSG101 protein. Mol Cell. 2004 Mar 26;13(6):783-9.
REF 103 Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J. 2007 Jul 25;26(14):3451-62.
REF 104 Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem. 2004 Jul 30;279(31):32786-95.
REF 105 Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol. 2006 Feb;8(2):163-9.
REF 106 Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics. 2012 Dec;11(12):1595-611.
REF 107 UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Curr Biol. 2011 Jul 26;21(14):1245-50.
REF 108 OTUD5 regulates p53 stability by deubiquitinating p53. PLoS One. 2013 Oct 15;8(10):e77682.
REF 109 The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell. 2005 Jul;8(1):75-87.
REF 110 Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat Struct Mol Biol. 2005 Aug;12(8):708-14.
REF 111 Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin. Mol Cell. 2015 Apr 16;58(2):297-310.
REF 112 The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites. J Biol Chem. 2004 Jul 23;279(30):31409-18.
REF 113 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 114 The zinc finger of NEMO is a functional ubiquitin-binding domain. J Biol Chem. 2009 Jan 30;284(5):2902-7.
REF 115 NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. EMBO J. 2009 Oct 7;28(19):2885-95.
REF 116 Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling. EMBO Rep. 2011 Feb;12(2):129-35.
REF 117 c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209.
REF 118 NEMO oligomerization and its ubiquitin-binding properties. Biochem J. 2009 Jun 26;421(2):243-51.
REF 119 Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell. 2006 Apr 21;22(2):245-57.
REF 120 Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr Biol. 2007 Aug 21;17(16):1438-43.
REF 121 SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity. Biochim Biophys Acta. 2015 Jan;1853(1):136-43.
REF 122 Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene. 2008 Jun 12;27(26):3739-45.
REF 123 Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol. 2002 May;4(5):394-8.
REF 124 Regulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo. Oncogenesis. 2017 Jun 5;6(6):e344.
REF 125 Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J Biol Chem. 2006 Aug 4;281(31):21640-51.
REF 126 USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response. Nat Commun. 2017 Jun 1;8:15752.
REF 127 NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80. J Biomol NMR. 2012 Apr;52(4):339-50.
REF 128 Mechanism for recognition of polyubiquitin chains: balancing affinity through interplay between multivalent binding and dynamics. J Am Chem Soc. 2010 Aug 18;132(32):11247-58.
REF 129 RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science. 2007 May 25;316(5828):1198-202.
REF 130 Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function. Oncogene. 2009 Apr 23;28(16):1843-52.
REF 131 Optineurin is required for CYLD-dependent inhibition of TNF-induced NF-B activation. PLoS One. 2011 Mar 7;6(3):e17477.
REF 132 Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. J Cell Sci. 2013 Jan 15;126(Pt 2):580-92.
REF 133 Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein. J Biol Chem. 2018 Jan 5;293(1):132-147.
REF 134 GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination. J Biol Chem. 2004 Feb 20;279(8):7105-11.
REF 135 Ubiquitin regulates GGA3-mediated degradation of BACE1. J Biol Chem. 2010 Jul 30;285(31):24108-19.
REF 136 The GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifs. J Biol Chem. 2004 Dec 24;279(52):54808-16.
REF 137 Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes. Mol Cell Biol. 2005 Sep;25(18):7988-8000.
REF 138 Ubiquitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation. PLoS One. 2012;7(8):e40361.
REF 139 Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1. Protein Sci. 2009 Nov;18(11):2265-76.
REF 140 Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD). J Biol Chem. 2013 Mar 8;288(10):6998-7011.
REF 141 A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J. 2003 Mar 17;22(6):1273-81.
REF 142 Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. J Biol Chem. 2004 Jun 4;279(23):24435-43.
REF 143 Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains. FEBS Lett. 2004 May 21;566(1-3):110-4.
REF 144 SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor. J Biol Chem. 2009 Dec 25;284(52):36062-76.
REF 145 Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1. Mol Cell Biol. 2014 Sep;34(17):3214-28.
REF 146 Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodies. J Biol Chem. 2009 Oct 2;284(40):27252-64.
REF 147 Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies. Acta Neuropathol. 2001 Oct;102(4):329-34.
REF 148 TCTP increases stability of hypoxia-inducible factor 1 by interaction with and degradation of the tumour suppressor VHL. Biol Cell. 2013 May;105(5):208-218.
REF 149 The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev. 1999 Jul 15;13(14):1822-33.
REF 150 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6.
REF 151 Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes. J Biol Chem. 2011 May 13;286(19):16726-33.
REF 152 Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK kinase-mediated antiviral response. Immunity. 2014 Jun 19;40(6):880-95.
REF 153 Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter. Mol Cell Biol. 2009 Jun;29(12):3401-12.
REF 154 Spartan/C1orf124 is important to prevent UV-induced mutagenesis. Cell Cycle. 2012 Sep 15;11(18):3395-402.
REF 155 DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nat Struct Mol Biol. 2012 Nov;19(11):1084-92.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.