Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | E3 ubiquitin protein ligase Itchy (ITCH) | Literature-reported | Target Info | ||
| UniProt ID | ITCH_HUMAN | ||||
| Gene Name | ITCH | ||||
| Gene ID | 83737 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Erbb4 tyrosine kinase receptor (Erbb-4) | Target Info | PPI Info | [1] | |
| C-X-C chemokine receptor type 4 (CXCR4) | Target Info | PPI Info | [2] | ||
| Interacting Clinical trial Target(s) | Mothers against decapentaplegic homolog 7 (SMAD7) | Target Info | PPI Info | [3] | |
| Interacting Patented-recorded Target(s) | Polyubiquitin-C (UBC) | Target Info | PPI Info | [4] | |
| Interacting Literature-reported Target(s) | E3 ubiquitin protein ligase Itchy (ITCH) | Target Info | PPI Info | [5] | |
| Vitamin D3 up-regulated protein 1 (VDUP1) | Target Info | PPI Info | [6] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4162-7. | ||||
| REF 2 | The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol Biol Cell. 2009 Mar;20(5):1324-39. | ||||
| REF 3 | USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063. | ||||
| REF 4 | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics. 2012 Aug;11(8):329-41. | ||||
| REF 5 | Itch self-polyubiquitylation occurs through lysine-63 linkages. Biochem Pharmacol. 2008 Dec 1;76(11):1515-21. | ||||
| REF 6 | The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem. 2010 Mar 19;285(12):8869-79. | ||||
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