Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T96079 Target Info
Target Name C-X-C chemokine receptor type 4 (CXCR4)
Synonyms Stromal cell-derived factor 1 receptor; SDF-1 receptor; NPYRL; Lipopolysaccharide-associated protein 3; Leukocyte-derived seven transmembrane domain receptor; LPS-associated protein 3; LESTR; LCR1; LAP-3; HM89; Fusin; FB22; Chemokine receptor CXCR4; CXCR-4; CXC-R4; CD184 antigen; CD184
Target Type Successful Target
Gene Name CXCR4
Biochemical Class GPCR rhodopsin
UniProt ID
CXCR4_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name E3 ubiquitin protein ligase Itchy (ITCH) Literature-reported Target Interacting Protein Info
UniProt ID
ITCH_HUMAN 
Synonyms NFE2-associated polypeptide 1; NAPP1; Itch; HECT-type E3 ubiquitin transferase Itchy homolog; E3 ubiquitin-protein ligase Itchy homolog; Atrophin-1-interacting protein 4; AIP4
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Co-fractionation [4]
5 Fluorescence Resonance Energy Transfer [1]
6 Reconstituted Complex [1]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Signal transducing adapter molecule 1 (STAM) Interacting Protein Interacting Protein Info
UniProt ID
STAM1_HUMAN 
Synonyms STAM.1; STAM1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [4]
2 Co-localization [5]
Other proteins [+] 1 Other proteins +
Interacting Target Name Stromal cell-derived factor 1 (CXCL12) Clinical trial Target Interacting Protein Info
UniProt ID
SDF1_HUMAN 
Synonyms SDF1B; SDF1A; SDF-1; SDF1; Pre-B cell growth-stimulating factor; Pre-B cell growth stimulating factor; PBSF; IRH; Intercrine reduced in hepatomas; hSDF-1; HIRH; C-X-C motif chemokine 12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-crystal Structure [7]
References  Top
REF 1 The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol Biol Cell. 2009 Mar;20(5):1324-39.
REF 2 HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. PLoS One. 2014 Jan 29;9(1):e86998.
REF 3 Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci. 2017 Apr 15;130(8):1475-1485.
REF 4 Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012 Mar 16;287(12):9013-27.
REF 5 Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. Mol Biol Cell. 2010 Jul 15;21(14):2529-41.
REF 6 High-Mobility Group Box-1 Modulates the Expression of Inflammatory and Angiogenic Signaling Pathways in Diabetic Retina. Curr Eye Res. 2015;40(11):1141-52.
REF 7 The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1 function through distinct receptor interactions. J Biol Chem. 2011 Sep 23;286(38):33466-77.

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