Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T77127 Target Info
Target Name Vitamin D3 up-regulated protein 1 (VDUP1)
Synonyms Vitamin D(3) up-regulating protein-1; Thioredoxin-interacting protein; Thioredoxin-binding protein 2
Target Type Literature-reported Target
Gene Name TXNIP
Biochemical Class Arrestin protein
UniProt ID
TXNIP_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name E3 ubiquitin protein ligase Itchy (ITCH) Literature-reported Target Interacting Protein Info
UniProt ID
ITCH_HUMAN 
Synonyms NFE2-associated polypeptide 1; NAPP1; Itch; HECT-type E3 ubiquitin transferase Itchy homolog; E3 ubiquitin-protein ligase Itchy homolog; Atrophin-1-interacting protein 4; AIP4
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [1]
3 Co-crystal Structure [2]
4 Proximity Label-MS [3]
5 Reconstituted Complex [2]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [5]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [2]
2 Reconstituted Complex [2]
Other proteins [+] 1 Other proteins +
Interacting Target Name Thioredoxin (TXN) Clinical trial Target Interacting Protein Info
UniProt ID
THIO_HUMAN 
Synonyms TRX1; Trx; TRDX; Surface-associated sulphydryl protein; Surface associated sulphydryl protein; SASP; ATL-derived factor; ADF
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [10]
6 Co-crystal Structure [10]
7 Reconstituted Complex [11]
8 Reconstituted Complex [10]
9 Yeast two hybrid [12]
10 Yeast two hybrid [13]
References  Top
REF 1 The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem. 2010 Mar 19;285(12):8869-79.
REF 2 Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem J. 2016 Jan 15;473(2):179-87.
REF 3 Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxid Med Cell Longev. 2016;2016:5829063.
REF 4 VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene. 2003 Jun 26;22(26):4035-46.
REF 5 Vitamin D3 upregulated protein 1 suppresses TNF--induced NF-B activation in hepatocarcinogenesis. J Immunol. 2010 Oct 1;185(7):3980-9.
REF 6 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 7 Thioredoxin regulates adipogenesis through thioredoxin-interacting protein (Txnip) protein stability. J Biol Chem. 2011 Aug 19;286(33):29139-45.
REF 8 Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). Exp Eye Res. 2007 Aug;85(2):270-9.
REF 9 Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1890-7.
REF 10 The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein. Nat Commun. 2014;5:2958.
REF 11 Structure of the N-terminal domain of human thioredoxin-interacting protein. Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):333-44.
REF 12 Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling. Endocrinology. 2006 Feb;147(2):733-43.
REF 13 TXNIP interacts with hEcd to increase p53 stability and activity. Biochem Biophys Res Commun. 2013 Aug 23;438(2):264-9.

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