Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T94695 Target Info
Target Name Mothers against decapentaplegic homolog 7 (SMAD7)
Synonyms hSMAD7; Smad7; SMAD family member 7; SMAD 7; Mothers against decapentaplegic homolog 8; Mothers against DPP homolog 8; MAD homolog 8
Target Type Clinical trial Target
Gene Name SMAD7
Biochemical Class Dwarfin/SMAD family
UniProt ID
SMAD7_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 7 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase SMURF2 (SMURF2) Interacting Protein Interacting Protein Info
UniProt ID
SMUF2_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Co-crystal Structure [4]
5 Reconstituted Complex [4]
Interacting Protein Name E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) Interacting Protein Interacting Protein Info
UniProt ID
NED4L_HUMAN 
Synonyms NEDD4.2; NEDD4.2; RSP5; hNEDD4.2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [4]
3 Co-crystal Structure [4]
4 Reconstituted Complex [4]
Interacting Protein Name E3 ubiquitin-protein ligase SMURF1 (SMURF1) Interacting Protein Interacting Protein Info
UniProt ID
SMUF1_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [3]
3 Co-crystal Structure [4]
4 Reconstituted Complex [4]
Interacting Target Name E3 ubiquitin protein ligase Itchy (ITCH) Literature-reported Target Interacting Protein Info
UniProt ID
ITCH_HUMAN 
Synonyms NFE2-associated polypeptide 1; NAPP1; Itch; HECT-type E3 ubiquitin transferase Itchy homolog; E3 ubiquitin-protein ligase Itchy homolog; Atrophin-1-interacting protein 4; AIP4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [5]
Interacting Target Name E3 ubiquitin-protein ligase NEDD4 (NEDD4) Literature-reported Target Interacting Protein Info
UniProt ID
NEDD4_HUMAN 
Synonyms Neural precursor cell expressed developmentally down-regulated protein 4; NEDD4-1; NEDD-4; KIAA0093; HECT-type E3 ubiquitin transferase NEDD4; Cell proliferation-inducing gene 53 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [6]
Interacting Protein Name E3 ubiquitin-protein ligase Arkadia (RNF111) Interacting Protein Interacting Protein Info
UniProt ID
RN111_HUMAN 
Synonyms ARK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [8]
Interacting Protein Name WW domain-containing protein 1 (WWP1) Interacting Protein Interacting Protein Info
UniProt ID
WWP1_HUMAN 
Synonyms WW domain-containing protein 1; Tiul1; TGIF-interacting ubiquitin ligase 1; NEDD4-like E3 ubiquitin-protein ligase WWP1; HECT-type E3 ubiquitin transferase WWP1; Atrophin-1-interacting protein 5; AIP5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [9]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [10]
Kinases [+] 1 Kinases +
Interacting Target Name TGF-beta receptor type I (TGFBR1) Clinical trial Target Interacting Protein Info
UniProt ID
TGFR1_HUMAN 
Synonyms Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-localization [12]
3 Reconstituted Complex [13]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 11 (USP11) Interacting Protein Interacting Protein Info
UniProt ID
UBP11_HUMAN 
Synonyms UHX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Co-fractionation [2]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Yes-associated protein 1 (YAP1) Literature-reported Target Interacting Protein Info
UniProt ID
YAP1_HUMAN 
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-crystal Structure [4]
3 Reconstituted Complex [4]
4 Yeast two hybrid [14]
Interacting Protein Name Mothers against DPP homolog 6 (MADH6) Interacting Protein Interacting Protein Info
UniProt ID
SMAD6_HUMAN 
Synonyms Smad6; SMAD family member 6; SMAD 6; Mothers against DPP homolog 6; Mothers against decapentaplegic homolog 6; MADH6; MAD homolog 6; hSMAD6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Yeast two hybrid [16]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) Literature-reported Target Interacting Protein Info
UniProt ID
WWP2_HUMAN 
Synonyms WW domain-containing protein 2; WW domaincontaining protein 2; NEDD4like E3 ubiquitinprotein ligaseWWP2; HECT-type E3 ubiquitin transferase WWP2; Atrophin-1-interacting protein 2; Atrophin1interacting protein 2; AIP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [17]
Other proteins [+] 1 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Co-localization [18]
References  Top
REF 1 TRAF4 promotes TGF- receptor signaling and drives breast cancer metastasis. Mol Cell. 2013 Sep 12;51(5):559-72.
REF 2 USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063.
REF 3 Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. J Clin Invest. 2004 Jan;113(2):253-64.
REF 4 Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF- Pathways. Structure. 2012 Oct 10;20(10):1726-36.
REF 5 AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism. J Biol Chem. 2005 Jul 29;280(30):27645-53.
REF 6 NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Biochem J. 2005 Mar 15;386(Pt 3):461-70.
REF 7 Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. EMBO J. 2003 Dec 15;22(24):6458-70.
REF 8 SET9-Mediated Regulation of TGF- Signaling Links Protein Methylation to Pulmonary Fibrosis. Cell Rep. 2016 Jun 21;15(12):2733-44.
REF 9 Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Oncogene. 2004 Sep 9;23(41):6914-23.
REF 10 The balance between acetylation and deacetylation controls Smad7 stability. J Biol Chem. 2005 Jun 10;280(23):21797-803.
REF 11 Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling. J Biol Chem. 2004 Jul 23;279(30):31568-74.
REF 12 Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor- signaling pathway. J Biol Chem. 2012 Nov 16;287(47):39653-63.
REF 13 The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell. 1997 Jun 27;89(7):1165-73.
REF 14 Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene. 2002 Jul 25;21(32):4879-84.
REF 15 Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor- (TGF-)/Smad Signaling. J Biol Chem. 2016 Jan 1;291(1):382-92.
REF 16 Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9314-9.
REF 17 Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGF signalling and EMT. Oncogene. 2011 May 26;30(21):2451-62.
REF 18 Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. Mol Cell Biol. 2005 Feb;25(4):1475-88.

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