Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) | ||||
| UniProt ID | NED4L_HUMAN | ||||
| Gene Name | NEDD4L | ||||
| Gene ID | 23327 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Serine/threonine-protein kinase Sgk1 (SGK1) | Target Info | PPI Info | [1] | |
| Mothers against decapentaplegic homolog 7 (SMAD7) | Target Info | PPI Info | [2] | ||
| Interacting Patented-recorded Target(s) | Polyubiquitin-C (UBC) | Target Info | PPI Info | [3] | |
| Interacting Literature-reported Target(s) | Angiomotin (AMOT) | Target Info | PPI Info | [4] | |
| Interacting Preclinical Target(s) | Mothers against decapentaplegic homolog 3 (SMAD3) | Target Info | PPI Info | [5] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS One. 2010 Aug 13;5(8):e12163. | ||||
| REF 2 | USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063. | ||||
| REF 3 | Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol Cell. 2009 Dec 25;36(6):1095-102. | ||||
| REF 4 | Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403. | ||||
| REF 5 | Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF- Pathways. Structure. 2012 Oct 10;20(10):1726-36. | ||||
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