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| Protein General Information (TTD Target) |
Top |
| Full Name |
Ubiquitin carboxyl-terminal hydrolase 2 (USP2)
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Preclinical
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Target Info
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| UniProt ID |
UBP2_HUMAN
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| Gene Name |
USP2
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| Gene ID |
9099
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| Interacting TTD Target Information |
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| Interacting Successful Target(s) |
Fatty acid synthase (FASN) |
Target Info
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PPI Info
|
[1] |
| Interacting Clinical trial Target(s) |
Receptor-interacting protein 1 (RIPK1) |
Target Info
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PPI Info
|
[2] |
| Interacting Patented-recorded Target(s) |
Polyubiquitin-C (UBC) |
Target Info
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PPI Info
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[3] |
| Interacting Literature-reported Target(s) |
TNF receptor-associated factor 6 (TRAF6) |
Target Info
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PPI Info
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[4] |
| References |
Top |
| REF 1 |
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 2004 Mar;5(3):253-61.
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| REF 2 |
De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Biochim Biophys Acta. 2012 Aug;1823(8):1353-65.
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| REF 3 |
Large-scale analysis of the human ubiquitin-related proteome. Proteomics. 2005 Nov;5(16):4145-51.
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| REF 4 |
USP2a positively regulates TCR-induced NF-B activation by bridging MALT1-TRAF6. Protein Cell. 2013 Jan;4(1):62-70.
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